Cinchonine hmoov CAS 118-10-5

Cinchonine, (1S) -quinoline-4-yl (5-vinylquinine-2-}yl) methanol, yog quinoline-type alkaloid, ib hom cinchona alkaloid, tseem hu ua cinchonine, qaug zog cinchona alkaloid, stereoisomer ntawm cinchonidine. Cinchonine yog ib qho alkaloid hauv Cinchonna bark nrog cov ntsiab lus ntau dua li quinine. Cinchonine yog ib qho tseem ceeb analytical reagent rau kev txiav txim siab ntawm tungsten ore los ntawm gravimetric tsom xam. Cinchonine thiab nws cov derivatives yog siv dav hauv kev npaj, sib cais thiab kev tshuaj xyuas ntawm cov tshuaj chiral thiab chiral intermediates.

Cov mis mos molecular C19H22N2O. Molecular hnyav 294.40. Dawb acicular lossis prismatic crystals tau los ntawm ether. Melting point 58 ~ 60 degree , [ ]D15+48 degree (ethanol, C=1). Sublimation pib ntawm 220 degree C. Soluble nyob rau hauv cawv, ether, acetone, benzene thiab chloroform, yuav luag insoluble nyob rau hauv dej txias. Cov xim yuav tsaus dua nyob rau hauv lub teeb, thiab feem ntau los yog yuav luag tag nrho nws cov aqueous tov yog hloov mus rau cincotoxin los ntawm kev ua ntawm phosphoric acid thiab organic acid (tshwj xeeb tshaj yog acetic acid) ntawm 98 ~ 100 degree, thaum tsis muaj los yog tsuas yog ib tug me me npaum li cas ntawm no transformation. tshwm sim hauv hydrochloric acid. Dihydrocinchonine tau tsim los ntawm palladium catalyzed hydrogenation hauv hydrochloric acid lossis acetic acid, thiab hexahydrocinchonine tau tsim los ntawm platinum pressurized hydrogenation hauv acetic acid ntawm 50 degree.