Khoom piav qhia
Obeticholic Acid, tseem hu ua 6-ethyl goosenodeoxycholic acid, yog ib qho tshiab derivative ntawm goosenodeoxycholic acid (CDCA) nyob rau hauv tib neeg cov kua tsib acids thiab ib tug natural ligand rau farnesate derivative X receptor (FXR). Obecholic acid yog ib tug farnesol X receptor agonist, uas tsis ncaj qha inhibits cytochrome 7A1 (CYP7A1) noob qhia los ntawm activating farnesol X receptor. Vim hais tias CYP7A1 yog tus nqi-txheej enzyme rau cholic acid biosynthesis, obecholic acid tuaj yeem inhibit cholic acid synthesis thiab yog siv rau hauv kev kho mob ntawm cov kab mob biliary cirrhosis thiab cov kab mob uas tsis yog-alcoholic fatty siab.
PBC yog ib qho mob cholestasis uas tshwm sim los ntawm cov kua tsib duct dysplasia los yog cov kua tsib acid metabolism tsis meej, uas ua rau lipid dissolution ntawm cell membrane, permeability hloov, cov ntsiab lus ntawm tes ntws tawm, thiab nws thiaj li mus rau daim siab fibrosis thiab cirrhosis. Tam sim no, ursodeoxycholic acid (URsodeoxycholic acid) yog cov tshuaj tseem ceeb siv hauv kev kho mob ntawm PBC. Ursodeoxycholic acid nkoos hepatobiliary secretion los ntawm intracellular signaling molecule mitogen-activated protein kinase (MAPK) txoj kev, thiab tiv thaiv epithelial hlwb los ntawm bile acid puas.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
COA
| Yam khoom | TSEEM CEEB | TSEEM CEEB |
| TSEEM CEEB | Tawm dawb mus rau dawb hmoov | Dawb hmoov |
| IDENTIFICATION | A: IR B: Lub sijhawm khaws cia |
Ua raws Ua raws |
| Dej | Tsawg dua lossis sib npaug rau 0.5% | 0.06% |
| HAIV NEEG | Tsawg dua lossis sib npaug rau 0.002% | Ua raws |
| ISOMERS | SFBD1 Tsawg dua lossis sib npaug rau 0.15% | Tsis pom |
| SFBD2 Tsawg dua lossis sib npaug rau 0.15% | Tsis pom | |
| SFBE Tsawg dua lossis sib npaug rau 0.15% | Tsis pom | |
| RESIDUE SOLBENTS | Methanol Tsawg dua los yog sib npaug rau 3000ppm | Tsis pom |
| Isopropyl cawv Tsawg dua lossis sib npaug li 5000ppm | 19ppm ua | |
| Dichloromethane Tsawg dua los yog sib npaug rau 600ppm | Tsis pom | |
| Tetrahydrofuran Tsawg dua lossis sib npaug rau 720ppm | Tsis pom | |
| Acetic acid Tsawg dua los yog sib npaug rau 5000ppm | Tsis pom | |
| Toluene Tsawg dua lossis sib npaug rau 890ppm | Tsis pom | |
| QHIA | Ntau dua lossis sib npaug li 99% | 99.80% |
| Xaus: | Ua raws li kev lag luam specification. | |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
Kev nyab xeeb npaum li cas yog obeticholic acid?
OCA yog contraindicated rau cov neeg mob uas ua tiav biliary obstruction. Obeticholic acid kuj yog contraindicated rau cov neeg mob uas decompensated cirrhosis (piv txwv li, Child-Pugh chav B lossis C) los yog them nyiaj cirrhosis nrog cov pov thawj ntawm portal hypertension, xws li gastroesophageal varices, ascites, los yog thrombocytopenia tsis tu ncua.
Lwm lub npe rau obeticholic acid yog dab tsi?
Obeticholic acid (OCA), muag nyob rau hauv lub npe Ocaliva, yog ib tug semi-synthetic bile acid analogue uas muaj cov qauv tshuaj 6 -ethyl-chenodeoxycholic acid. Nws yog siv los ua tshuaj siv los kho cov kab mob biliary cholangitis.
Dab tsi yog qhov generic rau obeticholic acid?
Nws tuaj yeem siv ib leeg lossis nrog lwm cov tshuaj hu ua ursodiol (Actigall). Tam sim no tsis muaj generic version ntawm Ocaliva (obeticholic acid), thiab nws feem ntau pom muaj nyob ntawm cov khw muag tshuaj tshwj xeeb nkaus xwb. Cov kev mob tshwm sim muaj xws li khaus, qaug zog, thiab mob plab, tab sis nws kuj muaj lus ceeb toom rau cov teeb meem siab.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
vim li cas xaiv peb
Peb lub Hoobkas
Pob
Shipping Txoj Kev
|
Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, thiab cov neeg muas zaub nyob rau hauv cov teb chaws Europe thiab America muaj peev xwm txaus siab rau xa cov khoom ncaj qha los ntawm ob qhov chaw. |
|
7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
|
|
15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
Cim npe nrov: obeticholic acid hmoov cas 459789-99-2, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua hauv Suav teb