Raw Powder API Imatinib CAS 152459-95-5

Raw Powder API ImatinibCov hmoov dawb, muaj cov tshuaj formula: C29H31N7O, molecular hnyav: 493.60, melting point: 113 degree, boiling point: 451 degree, thiab ceev ntawm 1.30 g / cm³. Imatinib yog tyrosine kinase inhibitor, ib qho me me molecule protein kinase inhibitor, uas tuaj yeem thaiv ib lossis ntau dua protein kinases. Nws yog siv los kho cov mob myeloid leukemia thiab malignant gastrointestinal stromal qog.

Imatinib yog dab tsi?

Raw Powder API Imatinibyog ib qho tshuaj hauv qhov ncauj siv los kho cov neeg laus nrog Philadelphia chromosome (Ber－Abl) zoo mob myelogenous leukemia (CML) nyob rau theem mob, theem nrawm, thiab theem ntev tom qab kev kho mob interferon tsis ua haujlwm. CML yog kab mob hematopoietic qia cell tshwm sim los ntawm qhov txawv txav DNA ntawm qia hlwb hauv cov pob txha pob txha. DNA txawv txav yuav tsim cov protein ntau txawv txav, cuam tshuam nrog cov txheej txheem ntawm leukocyte tsim nyob rau hauv cov pob txha pob txha, thiab nws thiaj li ua rau muaj kev nce qib ntawm leukocytes. CML tuaj yeem muab faib ua peb theem: theem mob, theem nrawm, thiab theem teeb meem. Lub sijhawm muaj sia nyob nruab nrab ntawm cov neeg mob nyob rau theem kev kub ntxhov tsuas yog 2-3 hli xwb. Imatinib tseem muaj txiaj ntsig zoo hauv kev kho mob plab hnyuv stromal, thiab qhov ua tau zoo yog kwv yees li 50%.

Keeb kwm kev loj hlob ntawm Imatinib:

Protein kinase tswj yuav luag txhua yam ntawm lub neej ntawm tes, thiab qhov kev hloov ntawm nws cov lus qhia lossis kev hloov pauv ntawm cov noob yuav ua rau mob qog noj ntshav thiab lwm yam kab mob. Piv txwv li, classic MAP kinase cascade kev hloov pauv tuaj yeem ua rau mob qog noj ntshav. Txij li thaum imatinib mus rau hauv kev ua lag luam hauv xyoo 2001, kinase inhibitors tau dhau 20 xyoo. Seb puas yog cov protein kinase tuaj yeem siv los ua lub hom phiaj tshuaj tau ua rau tsis ntseeg los ntawm ntau lub tuam txhab tshuaj ua ntej. Txog xyoo 1998, imatinib tau nkag mus rau kev sim tshuaj, uas hloov tib neeg txoj kev xav ntawm cov protein kinase raws li lub hom phiaj tshuaj. Txij thaum ntawd los, pua pua ntawm cov protein kinase inhibitors tau tsim thiab sim hauv tib neeg, yog li qhib lub sijhawm ntawm kev npaj tshuaj kho mob.

Hauv xyoo 2001, imatinib, thawj kinase inhibitor, tau pom zoo los ntawm FDA.

Imatinib ua haujlwm li cas?

Raw Powder API Imatinib, ib tug derivative ntawm Phenylpyrimidine, yog ib tug tshiab tyrosine kinase inhibitor. Kwv yees li 95% ntawm cov neeg mob uas muaj kab mob leukemia thiab CML muaj ph chromosome zoo, uas yog, proto-oncogene ABL ntawm chromosome 9 yog ectopic rau oncogene ntawm chromosome 22 hu ua breakthrough clustering region, BCR, thiab ob lub noob recombine ua ke los tsim cov fusion protein p-210, uas muaj tyrosine kinase ntau dua li cov C-ABL protein ib txwm p-150. Nws tuaj yeem tiv thaiv kev ua haujlwm ntawm ABL tyrosine kinase hauv vivo thiab hauv vitro, tshwj xeeb yog inhibiting kev qhia ntawm ABL thiab kev loj hlob ntawm BCR-ABL hlwb, yog li nws tuaj yeem siv los kho CML. Tsis tas li ntawd, nws tuaj yeem cuam tshuam tyrosine kinases ntawm platelet-derived kev loj hlob yam, PDGF, qia cell factor, thiab SCF receptor, thiab inhibit biochemical cov tshuaj tiv thaiv los ntawm PDGF thiab SCF, tab sis nws tsis cuam tshuam rau lub teeb liab hloov ntawm lwm yam stimulating yam.

Dab tsi yog kev ceev faj rau kev siv Imatinib?

1. Lub siab ua haujlwm (xws li transaminase, serum bilirubin, thiab alkaline phosphatase) yuav tsum tau kuaj xyuas ua ntej kho, thiab nws tuaj yeem kuaj xyuas ib hlis ib zaug tom qab.

2. Cov ntshav yuav tsum tau kuaj txhua lub lim tiam hauv thawj lub hlis ntawm kev kho mob thiab ib zaug txhua 2 lub lis piam hauv lub hlis thib ob.

3. Nws raug nquahu kom saib xyuas qhov hnyav tsis tu ncua.

Leej twg tsis tuaj yeem siv Imatinib?

1. Cov neeg uas tsis haum rau cov khoom no yog txwv tsis pub.

2. Siv ceev faj rau cov neeg mob uas muaj kab mob siab tsis txaus.

3. Siv ceev faj rau cov neeg mob uas mob plawv tsis ua hauj lwm.

4. Kev sim tsiaj txhu pom tias cov khoom no yog teratogenic, thiab tseem tsis muaj cov ntaub ntawv tshuaj rau cov poj niam cev xeeb tub, yog li cov poj niam cev xeeb tub yuav tsum siv ceev faj.

5. Kev faib tawm ntawm tib neeg thiab tsiaj cov mis nyuj uas tuaj yeem tso rau hauv cov kua mis ntau hauv tib neeg tsis paub meej, yog li cov poj niam lactating yuav tsum siv ceev faj.

6. Siv ceev faj rau cov neeg mob uas muaj myelosuppression.

7. Siv ceev faj rau cov neeg mob uas muaj kab mob los yog kab mob.

8. Siv ceev faj rau cov neeg mob plab hnyuv.

Yuav xaiv cov khoom siv li cas

Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.

Koj tuaj yeem tiv tauj kuv ntawm WhatsApp:+86 13137770562

Muaj ntau txoj kev xa khoom rau koj xaiv

Tsis lees paub: Cov ntawv luam tawm ntawm lub vev xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.

Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho lossis tiv thaiv kab mob.

Cim npe nrov: raw hmoov api imatinib cas 152459-95-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, kev muag khoom