Raw Powder Topotecan Hydrochloride CAS 119413-54-6

Raw Powder Topotecan Hydrochlorideyog lub teeb daj koob zoo li crystalline hmoov nrog cov qauv molecular: C23H24ClN3O5, molecular hnyav: 457.91, thiab melting point: 213-218 C. Nws tuaj yeem siv rau kev kho mob ntawm tag nrho cov qog nqaij hlav.

Topotecan Hcl, semi-synthetic camptothecin derivative, yog ib qho tshuaj tiv thaiv qog nqaij hlav uas tuaj yeem cuam tshuam cov kev ua ntawm topoisomerase I. Topo isomerase Kuv tuaj yeem ua rau thim rov qab DNA ib leeg-strand breakage, loosen DNA kauv strand, ua ke nrog Topoisomerase I-DNA complex thiab tiv thaiv kev sib txuas ntawm cov kev sib txuas ib leeg. Nws cov nyhuv cytotoxic yog nyob rau hauv cov synthesis ntawm DNA, thiab nws yog ib qho tshuaj tshwj xeeb rau S-phase cell voj voog. Txij li thaum nws cov synthesis, nws tau pom tias nws muaj txiaj ntsig zoo rau kev mob qog noj ntshav ntawm zes qe menyuam, tshwj xeeb tshaj yog rau cov neeg mob qog noj ntshav zes qe menyuam uas tiv taus cisplatin. Nws yog thawj zaug sau npe hauv Tebchaws Meskas los ntawm GlaxoSmithKline Pharmaceutical Company hauv xyoo 1996, thiab nws tseem yog thawj cov tshuaj tiv thaiv qog noj ntshav hauv ntiaj teb uas ua rau Topol Isomerase I, nrog lub npe lag luam ntawm "Meixin", thiab tau pom zoo rau kev kho mob. ntawm zes qe menyuam qog noj ntshav thiab qog nqaij hlav qog nqaij hlav me me.

Topotecan Hydrochloride yog dab tsi?

Raw Powder Topotecan Hydrochlorideyog ib qho dej-soluble camptothecin derivative, uas yog hydrochloride daim ntawv ntawm Topotecan.

Topotecan HCl yog ib tug semi-synthetic anti-tumor tshuaj teev los ntawm SmithklineBeecham Pharmaceutical Company nyob rau hauv lub tebchaws United States nyob rau hauv 1996, thiab nws kuj yog thawj anti-tumor tshuaj nyob rau hauv lub ntiaj teb no uas ua rau topoisomerase I. Nws qhia ib tug ruaj khov puag sab saw ntawm 9 txoj hauj lwm ntawm lub nplhaib A nyob rau hauv cov qauv tshuaj ntawm hydroxycamptothecin, thiab khaws cov S conformation ntawm txoj hauj lwm ntawm chiral carbon 20. Lub hauv paus sab saw txuas ntxiv cov dej solubility ntawm cov compound thiab txo cov hydrolysis ntawm cov lactone nrog cov kev ua ntawm cov roj ntsha. E lub nplhaib. Piv nrog rau lwm cov tshuaj camptothecin, nws muaj zog antitumor kev ua si thiab tsawg dua cov tshuaj lom.

Topotecan Hydrochloride siv tau rau dab tsi?

Raw Powder Topotecan Hydrochloridetuaj yeem siv rau kev kho mob ntawm tag nrho cov qog nqaij hlav, thiab tag nrho cov txiaj ntsig zoo ntawm cov neeg mob qog noj ntshav ntawm zes qe menyuam uas rov qab los tom qab platinum antitumor tshuaj zoo dua li ntawm paclitaxel.

Nws kuj tseem muaj txiaj ntsig zoo rau kev kho mob qog noj ntshav ntawm lub ntsws me me,

Nws muaj cov txiaj ntsig zoo rau kev mob qog noj ntshav ntawm lub mis, mob qog nqaij hlav hauv plab, mob leukemia, thiab lymphoma,

Nws muaj qhov ua tiav kev tso tawm siab rau myelodysplastic syndrome thiab mob myelomonocytic leukemia.

Topotecan hydrochloride muaj cov txiaj ntsig zoo rau kev mob qog noj ntshav ntawm lub zes qe menyuam, tshwj xeeb tshaj yog rau cov neeg mob uas muaj mob qog noj ntshav ntawm zes qe menyuam uas tau ua tsis zoo tom qab kev kho thawj kab nrog cov tshuaj platinum. Phase II kev tshawb fawb soj ntsuam kuj pom tau tias topotecan hydrochloride muaj kev kho mob zoo ntawm cov qog nqaij hlav hauv lub ntsws me me, nrog rau cov qog nqaij hlav me me hauv lub ntsws tom qab ua tsis tiav ntawm thawj kab kev kho mob, thiab tag nrho cov kev tshem tawm yog nyob nruab nrab ntawm 19% thiab 39.8%. Tsis tas li ntawd, topotecan muaj txiaj ntsig zoo hauv kev kho mob qog nqaij hlav hauv taub hau thiab caj dab, mob qog noj ntshav mis, mob qog noj ntshav uas tsis yog melanoma, melanoma, cov nqaij mos sarcoma, glioma, thiab lwm yam kab mob.

Dab tsi yog cov teebmeem ntawm kev siv topotecan hydrochloride?

Ntawm ib koob tshuaj tsawg, topotecan hydrochloride tuaj yeem ua rau pob txha pob txha thiab lwm yam tshuaj lom, tshwj xeeb tshaj yog neutropenia. Nws kuj feem ntau ua rau thrombocytopenia thiab ntshav ntshav, thiab qee zaum yuav tsum tau txhaj cov qe ntshav liab thiab platelets. xeev siab, ntuav, alopecia, raws plab, mob plab, gastritis, thiab qaug zog kuj tuaj yeem tshwm sim, tab sis lawv txhua tus mob me.

Yuav xaiv cov khoom siv li cas

Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.

Koj tuaj yeem tiv tauj kuv ntawm WhatsApp:+86 13137770562

Muaj ntau hom kev xa khoom rau koj xaiv

Tsis lees paub: Cov ntawv luam tawm ntawm lub vev xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.

Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho lossis tiv thaiv kab mob.

Cim npe nrov: Raw hmoov topotecan hydrochloride cas 119413-54-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, muag