Vinblastine Sulphate hmoov, alkaloid muab rho tawm los ntawm Catharanthus roseus ntawm oleander, yog ib lub xovtooj ntawm tes, lub voj voog tshwj xeeb antineoplastic tus neeg sawv cev. Nws yog tsuas yog siv rau kev kho mob ntawm Hodgkin tus kab mob thiab malignant lymphoma, thiab tseem siv tau rau kev kho mob choriocarcinoma thiab mob cancer ntawm lub mis. Nws kuj tseem siv tau rau kev mob qog nqaij hlav bronchial, cov nqaij mos sarcoma, qog qog, qog nqaij hlav ntawm zes qe menyuam, mob plab hnyuv, vicious kauv melanoma, thiab neuroblastoma. Nws yog ib qho ntawm feem ntau siv tshuaj ntsuab tshuaj tiv thaiv kab mob hauv ntiaj teb.
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| Vinblastine Sulphate hmoov | Vinblastine Sulfate Molecular Formula |
Dab tsi yog kev siv vinblastine sulfate?
Vinblastine Sulphate hmoov, raws li lub voj voog ntawm cov tshuaj tiv thaiv kab mob tshwj xeeb, ua rau G1, s, thiab M theem thiab ncua sijhawm M. Nws tuaj yeem cuam tshuam nrog kev tsim cov cell spindle thiab nres mitosis hauv nruab nrab theem. Thaum noj ntau dua, nws tuaj yeem cuam tshuam ncaj qha chromosomes, crystallize microtubule proteins thiab tiv thaiv kev sib sau ntawm microtubule proteins. Tsis tas li ntawd, cov khoom no muaj cov nyhuv immunosuppressive.
Raws li lub ntuj alkaloid, vinblastine sulfate tuaj yeem khi rau tubulin thiab inhibit qhov tsim ntawm microtubules, uas ua rau kev faib cov mitotic spindle thiab qhov txawv txav ntawm cov qog hlwb hauv M theem ntawm lub voj voog ntawm tes.
Tib lub sijhawm, nws kuj tuaj yeem siv los kho Hodgkin tus kab mob thiab Chorioepithelioma. Nws kuj muaj qee yam cuam tshuam rau malignant lymphosarcoma, mob leukemia, mob cancer mis, thiab lwm yam.
Cov kev phiv ntawm vinblastine sulfate yog dab tsi?
Lub npe lag luam ntawm vinblastine sulfate yog Weibaoding. Txawm hais tias cov khoom no muaj txiaj ntsig zoo hauv kev kho cov qog nqaij hlav. Txawm li cas los xij, cov khoom no kuj muaj cov txiaj ntsig pom tseeb ntawm cov pob txha pob txha, uas yog pom tseeb dua li vincristine. Cov tsos mob tseem ceeb yog leukocyte thiab platelet poob, uas rov qab sai sai tom qab tso tseg cov tshuaj., ntxiv rau, muaj cov kab mob hauv plab, uas feem ntau mob me. Cov khoom no kuj tseem tuaj yeem ua rau peripheral neuritis, xws li mob ko taw, loog ntawm lub ntsis ntiv tes (toes), nqaij ntshiv, qhov ploj ntawm cov leeg nqaij, thiab qee qhov yuav mob taub hau thiab kev nyuaj siab. Lwm yam xws li plaub hau poob, insomnia, thiab postural hypotension.
Lub hauv paus ntsiab lus ua haujlwm ntawm vinblastine sulfate yog dab tsi?
Cov qog nqaij hlav cancer yog tus cwj pwm los ntawm kev faib tawm ntawm tes, uas tsis tau tswj hwm ib yam li cov ntaub so ntswg. Cov hlwb ib txwm tsis sib faib thaum lawv tau ntsib nrog cov hlwb zoo sib xws. Cov txheej txheem no hu ua hu ua inhibition. Cov qog nqaij hlav cancer poob qhov peev xwm no. Cov qog nqaij hlav cancer tsis muaj cov kev kuaj xyuas ib txwm muaj thiab kev sib npaug uas tswj thiab txwv kev faib cell. Cov txheej txheem ntawm kev faib tawm ntawm tes, txawm tias cov cell qub lossis cov qog nqaij hlav cancer, yog ua los ntawm lub voj voog ntawm tes. Lub voj voog ntawm tes mus los ntawm theem quiescent mus rau theem kev loj hlob, thiab tom qab ntawd mus rau mitotic cancer. Cov qog yog tus cwj pwm los ntawm kev faib tawm ntawm tes, uas tsis tau tswj hwm ib yam li cov ntaub so ntswg. Cov hlwb ib txwm tsis sib faib thaum lawv tau ntsib nrog cov hlwb zoo sib xws. Cov txheej txheem no hu ua hu ua inhibition. Cov qog nqaij hlav cancer poob qhov peev xwm no. Cov qog nqaij hlav cancer tsis muaj cov kev kuaj xyuas ib txwm muaj thiab kev sib npaug uas tswj thiab txwv kev faib cell. Cov txheej txheem ntawm kev faib tawm ntawm tes, txawm tias cov cell qub lossis cov qog nqaij hlav cancer, yog ua los ntawm lub voj voog ntawm tes. Lub voj voog ntawm tes dhau los ntawm theem quiescent mus rau theem kev loj hlob, thiab tom qab ntawd mus rau mitosis
Lub peev xwm ntawm chemotherapy los tua cov qog nqaij hlav cancer nyob ntawm nws lub peev xwm los tiv thaiv kev faib tawm ntawm tes. Feem ntau, cov tshuaj ua haujlwm los ntawm kev rhuav tshem RNA lossis DNA uas qhia cov hlwb yuav ua li cas rov ua dua lawv tus kheej thaum sib faib. Yog tias cov hlwb tsis tuaj yeem faib tau, lawv yuav tuag. Qhov ceev ntawm cov cell sib faib, qhov ntau dua cov tshuaj tua kab mob yog tua cov hlwb thiab ua rau cov qog nqaij hlav. Lawv kuj induce cell suicide (self-death or apoptosis).
Cov tshuaj chemotherapeutic uas cuam tshuam rau cov hlwb tsuas yog thaum lub sij hawm faib cell hu ua cell cycle-specific drugs. Thaum cov cell so, cov tshuaj chemotherapeutic uas cuam tshuam rau cov hlwb hu ua cell-cycle nonspecificity. Lub sijhawm ntawm kev kho tshuaj khomob yog txiav txim siab los ntawm hom cell, lawv qhov kev faib tawm, thiab lub sijhawm uas cov tshuaj muab tau zoo. Qhov no yog vim li cas chemotherapy feem ntau yog ua txhua lub sijhawm.
Kev siv tshuaj khomob yog qhov ua tau zoo tshaj plaws hauv kev tua cov cell faib sai. Hmoov tsis zoo, chemotherapy tsis paub qhov txawv ntawm cov qog nqaij hlav cancer thiab cov hlwb ib txwm muaj. Cov hlwb ib txwm yuav rov ua dua thiab noj qab nyob zoo, tab sis tib lub sijhawm, yuav muaj kev phiv. Cov hlwb ib txwm muaj feem cuam tshuam los ntawm kev siv tshuaj khomob yog cov qe ntshav, cov hlwb hauv lub qhov ncauj, plab, hnyuv, thiab cov hauv paus plaub hau; Qhov no ua rau cov ntshav qis qis, qhov ncauj qhov ntswg, xeev siab, raws plab, thiab / lossis plaub hau poob. Cov tshuaj sib txawv tuaj yeem cuam tshuam rau qhov sib txawv ntawm lub cev.
Vinblastine Sulphate hmoovbelongs rau ib chav kawm ntawm chemotherapeutic tshuaj hu ua alkaloids. Cog alkaloids yog tsim los ntawm cov nroj tsuag. Catharanthus roseus alkaloids yog tsim los ntawm Catharanthus roseus (Catharanthus roseus). Cog alkaloids muaj lub voj voog ntawm tes tshwj xeeb. Qhov no txhais tau hais tias lawv tua cov hlwb ntawm txhua theem ntawm kev faib tawm.
Cov tshuaj tiv thaiv microtubule (xws li vinblastine) inhibit cov qauv microtubule hauv cov hlwb. Microtubules yog ib feem ntawm cov cuab yeej rau kev faib tawm ntawm tes thiab rov ua dua. Inhibition ntawm cov qauv no nws thiaj li ua rau cell tuag.
Tsis lees paub: tshwj tsis yog tias tau teev tseg, tsab xov xwm kev paub luam tawm los ntawm lub vev xaib no los ntawm Is Taws Nem thiab feem ntau yog siv los txhawb kev sib pauv kev kawm thiab kev kawm. Nws tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov ua tib zoo tshuaj xyuas nws. Yog tias koj xav tias muaj kev ua txhaum cai hauv tsab xov xwm no, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab kev pabcuam ntawm lub vev xaib no.
Nco tseg: Tag nrho cov tebchaw muaj kev pheej hmoo. Thov nrog koj tus kws qhia ntawv, kws kho mob, lossis lwm tus kws tshawb fawb ua ntej siv. Cov khoom no tsis yog siv los kuaj xyuas, tiv thaiv lossis kho cov kab mob, tab sis tsuas yog siv rau kev tshawb fawb tshawb fawb. Lub tuam txhab tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.
Yog tias koj xav tau kev pab, thov hu rau peb
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