Teicoplanin CAS 61036-62-2

Teicoplaninyog glycopeptide tshuaj tua kab mob uas tsim los ntawm fermentation ntawm actinomycetes. Nws yog ib tiam tshiab ntawm cov tshuaj tua kab mob glycopeptide tsim tom qab vancomycin. Teicoplanin tam sim no yog ib qho kev cog lus zoo tshaj plaws los tiv thaiv cov tshuaj tua kab mob hauv tsev kho mob, nrog cov roj solubility muaj zog thiab ntev ib nrab ntawm lub neej tshaj vancomycin. Nws muaj cov kua dej zoo hauv lub cev, lub teeb pom kev tsis zoo, tuaj yeem siv los ntawm cov leeg nqaij, thiab yooj yim dua rau daim ntawv thov. Teicoplanin yog txuam nrog kev nce me me hauv plab hnyuv colonizing Candida albicans. Cov nyhuv inhibitory ntawm Teicoplanin ntawm proteoglycan polymerization tab sis tsis yog nyob rau ntawm nucleic acid thiab protein synthesis qhia tias cov nyhuv ntawm phab ntsa yog vim lub tsub zuj zuj ntawm theem ntawm soluble precursors ntawm proteoglycan tsis tu ncua tsim los ntawm lub cell.

Lub mechanism ntawm kev txiav txim yog inhibit lub synthesis ntawm cell phab ntsa thiab cuam tshuam nrog synthesis ntawm tshiab qhov chaw nyob rau hauv peptidoglycan. Cov tshuaj khi rau cov aminoacyl-D-alanylon-D-alanine thaum kawg ntawm mucopeptide nyob rau hauv lub cell phab ntsa ntawm cov kab mob nyob rau hauv lub faib thiab yug me nyuam theem, yog li tiv thaiv lub synthesis ntawm cov kab mob ntawm lub cell phab ntsa membrane thiab ua tiav cov inhibition thiab tua. ntawm cov kab mob. Cov khoom no muaj txiaj ntsig zoo tiv thaiv kab mob gram-positive aerobic thiab anaerobic kab mob, suav nrog Staphylococcus aureus thiab coagulase tsis zoo staphylococcus (xws li methicillin-resistant strains), Streptococcus pyogenes, Streptococcus pneumoniae, corynebacterium, Clostridium difficile khoom, thiab lwm yam. kab mob gram-negative.