Valdecoxib yog dab tsi?
Valdecoxib yog ib qho zoo thiab xaiv inhibitor ntawm COX-2. IC50 qhov tseem ceeb ntawm COX-2 thiab COX-1 yog 5 nM thiab 140 μM, feem, uas tuaj yeem siv rau kev kawm txog kev mob caj dab thiab mob.
Valdecoxib hmoovyog cov hmoov dawb los yog daj daj crystalline, uas yog insoluble nyob rau hauv dej (10μ g mL-1) ntawm chav tsev kub nrog pH 7.0, soluble nyob rau hauv methanol thiab ethanol, thiab heev soluble nyob rau hauv organic solvents thiab alkaline. aqueous daws.
Valdecoxib tsis yog tsuas yog qhov tseem ceeb nruab nrab ntawm cov synthesis ntawm parecoxib sodium, tab sis kuj yog cov khoom tseem ceeb hydrolysis, uas yog lub ntsiab impurity nyob rau hauv kev soj ntsuam ntawm lwm yam tshuaj ntawm parecoxib sodium. Parecoxib, cov tshuaj uas tsis yog-steroidal anti-inflammatory, yog ib qho amide precursor compound (dej-soluble precursor) ntawm COX heev xaiv -2 inhibitor vardixib. Tom qab kev tswj hwm txoj hlab ntshav, parecoxib tau nrawm nrawm rau hauv vardixib los ntawm carboxylesterase, yog li ua si lub luag haujlwm tiv thaiv kev mob thiab ua kom mob plab.
| Khoom npe | Valdecoxib |
| CAS | 181695-72-7 |
| Cov mis mos molecular | C16H14N2O3S |
| Molecular hnyav | 314.36 |
| EINECS Number | 803-082-3 |
| Kev cia khoom | chav kub |
| Melting point | 162-164 degree |
| Solubility | Dimethyl sulfoxide:> 25mg / ml |
| Qhov tshwm sim | Dawb mus rau dawb hmoov |
| Boiling point | 481.2 ± 55. 0 degree (Predicted) |
| Qhov ntom | 1.3 03 ± 0.06 g / cm3 (Tshaj tawm) |
Dab tsi yog pharmacological kev txiav txim ntawm Valdecoxib?
Valdecoxib hmoovNws yog ib qho tshuaj uas tsis yog-steroidal anti-inflammatory, uas muaj cov nyhuv anti-inflammatory, analgesic thiab antipyretic. Nws cov txheej txheem yog tsuas yog inhibit qhov synthesis ntawm prostaglandin los ntawm inhibiting cyclooxygenase -2(COX-2). Valdecoxib tsis muaj kev cuam tshuam rau cyclooxygenase -1 (COX-1) uas tiv thaiv lub plab mucosa. Hauv vitro, qhov kev xaiv ua piv txwv ntawm Valdecoxib rau COX-2 thiab COX-1 yog 30, thaum rofecoxib yog 35 thiab celecoxib yog 7.6.
Khoom Specification
| Yam khoom | Specification | Cov txiaj ntsig |
| Kev txheeb xyuas | IR spectrum zoo ib yam li RS | Ua raws |
| HPLC tuav lub sij hawm zoo ib yam li RS | Ua raws | |
| Muaj feem xyuam | Tag nrho cov impurities: NMT0.3% | 0.02% |
| Ib qho impurity: NMT0.1% | 0.01% | |
| Cov hlau hnyav | NMT 10 ppm | 8ppm ua |
| Poob rau ziab | NMT 0.5% | 0.10% |
| Residue ntawm ignition | NMT0.1% | 0.02% |
| Assay | 98.5%-101.0% | 99.88% |
| Xaus: Ua raws li USP Standard | ||
Pharmacodynamics ntawm Valdecoxib
Valdecoxib yog ib qho kev xaiv cyclooxygenase -2 (COX-2) inhibitor thiab raug cais raws li cov tshuaj uas tsis yog-steroidal anti-inflammatory (NSAID). Valdecoxib yog siv los kho osteoarthritis (OA) thiab dysmenorrhea lossis mob hnyav vim nws cov tshuaj tiv thaiv, tshuaj tua kab mob thiab tshuaj tua kab mob. Tsis zoo li Celecoxib, Valdecoxib tsis muaj sulfonamide saw thiab tsis xav tau CYP450 enzyme rau cov metabolism.
HTML5 atlas of Valdecoxib
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Synthesis method of Valdecoxib:
Phenylbenzyl ketone yog ib qho tseem ceeb nruab nrab ntawm cov synthesis ntawm Valdecoxib. Nws tau tshaj tawm nyob rau hauv cov ntaub ntawv hais tias benzophenone, bromobenzyl, benzoyl chloride, benzaldehyde thiab potassium cyanide yog siv los ua raw khoom thiab tau los ntawm kev ntxiv los yog condensation. Txawm li cas los xij, cov khoom siv raw siv hauv cov txheej txheem no kim heev (xws li Ph Se CH2Li, thiab lwm yam) lossis cov tshuaj tiv thaiv hnyav (xws li -78 degree , thiab lwm yam), thiab cov txiaj ntsig qis. Nyob rau hauv tas li ntawd, nyob rau hauv lub synthesis ntawm intermediate 5- hydroxy -5- methyl -3, 4- diphenyl isoxazole, lithium diisopropylamide nrog tus nqi siab tau siv raws li catalyst, thiab cov tawm los yog tsawg thiab kev ua haujlwm tsis yooj yim. Qhov tseem ceeb nruab nrab 2 tuaj yeem tau txais los ntawm phenylacetonitrile thiab methyl benzoate los ntawm Claisen condensation one-pot method. Siv n-butyl lithium ua catalyst thiab acetic anhydride li acetylation nplhaib-kaw reagent, qhov tseem ceeb nruab nrab 4 tau txais, thiab cov txiaj ntsig tau nce los ntawm 57.7% mus rau 69.3%. Ces lub hom phiaj khoomValdecoxib hmoovtau txais los ntawm sulfonamide.
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Dab tsi yog kev ceev faj rau kev siv Valdecoxib hmoov?
1. Siv ceev faj rau cov neeg mob uas muaj dej tuav, kub siab lossis lub plawv tsis ua haujlwm thiab cov neeg mob uas muaj kab mob siab thiab raum.
2. Valdecoxib hloov tsis tau corticosteroids. Kev tshem tawm ntawm corticosteroids tam sim ntawd tuaj yeem ua rau muaj qhov hnyav ntawm cov kab mob corticosteroid, thiab kev tshem tawm ntawm corticosteroids yuav tsum maj mam txo.
3. Valdecoxib tuaj yeem nce alanine aminotransferase (ALT) thiab aspartate aminotransferase (AST). Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo yuav tsum saib xyuas kev txhim kho ntawm daim siab mob hnyav.
4. Hemoglobin lossis cov qe ntshav liab ntim yuav tsum tau kuaj kom siv Valdecoxib mus ntev.
5. Kev nyab xeeb tshuaj ntawm cov menyuam yaus hnub nyoog qis dua 18 xyoo tsis tau raug ntsuas.
6. Khaws ntawm 15 ~ 30 degree
Yuav ua li cas thiab qhov twg yuav Valdecoxib Powder wholesale?
Koj tuaj yeem tso siab rau peb qhov kev txiav txim vim tias peb muaj cov ntaub ntawv zoo ntawm kev muag tshuaj raws cai.
Peb ua qhov kev kuaj xyuas ywj pheej ntawm txhua yam khoom thiab tom qab ntawd muag rau peb cov neeg siv khoom hwm.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Tsis lees paub: Cov ntawv luam tawm ntawm lub xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.
Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho, lossis tiv thaiv txhua yam kab mob.
Cim npe nrov: valdecoxib hmoov cas 181695-72-7, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Tuam Tshoj