Ethynyl Estradiol hmoov CAS 57-63-6

Ethynyl estradiol hmoovyog {{0}} hydroxy -19- los yog 17 -pregnane -1,3,5⑽- triene -20- alkyne-17-ol. Muab xam los ntawm cov khoom qhuav, cov ntsiab lus ntawm C20H24O2 yuav tsum yog 97.0% ~ 103.0%.

Nws yog dawb los yog dawb zoo li crystalline hmoov; Tsis hnov ​​tsw.

Cov khoom yog soluble hauv ethanol, propanol, lossis ether, soluble hauv chloroform, thiab insoluble hauv dej.

Melting point Lub melting point ntawm cov khoom no yog 180 ~ 186 degree.

Kev sib hloov tshwj xeeb yuav siv cov khoom, hnyav nws meej, ntxiv pyridine kom yaj nws, thiab dilutes nws kom muaj nuj nqis los ua cov tshuaj uas muaj txog 10mg ib 1ml.

Raws li txoj cai, qhov kev hloov pauv tshwj xeeb yog -26 rau -31.

[Kev txiav txim siab cov ntsiab lus]Kev txiav txim siab los ntawm kev ua haujlwm siab ua kua chromatography. Chromatographic tej yam kev mob thiab system applicability test siv octadecyl silane bonded silica gel li muab tub lim; Methanol-dej (70:30) yog lub sijhawm txawb, thiab kev tshawb pom wavelength yog 281nm. Tus lej xov tooj theoretical yuav tsum tsis pub tsawg dua 1, 000 raws li Ethynyl estradiol ncov, thiab kev sib cais degree ntawm Ethynyl estradiol ncov thiab cov khoom siv sab hauv yuav tsum ua raws li qhov yuav tsum tau ua.

Kev npaj cov txheej txheem sab hauv Siv txog 20mg megestrol acetate, ntsuas kom raug, muab tso rau hauv 10ml ntim ntim, yaj hauv cov dej cawv tsis huv, dilute nws mus rau qhov ntsuas, thiab co nws kom zoo.

Ethynyl estradiol yog dab tsi?

Ethynyl estradiol hmoovyog ib qho tshuaj estrogen, uas yog siv dav hauv cov tshuaj tiv thaiv kab mob ua ke nrog progesterone. Yav dhau los, nws tau siv dav hauv ntau yam kev qhia, xws li kho cov tsos mob climacteric, kab mob gynecological, thiab qee cov qog nqaij hlav hormone-rhiab heev. Nws feem ntau yog noj los ntawm qhov ncauj, tab sis nws kuj yog siv los ua ib lub nplhaib thiab qhov chaw mos.

Nws cov kev mob tshwm sim muaj xws li mob lub mis, mob taub hau, kua dej, thiab xeev siab. Hauv cov txiv neej, nws tuaj yeem ua rau lub mis loj hlob, kev ua feminization, hypogonadism, thiab kev sib deev tsis zoo. Tab sis qhov tshwm sim tsawg thiab hnyav muaj xws li thrombosis, mob siab rau, thiab mob qog noj ntshav hauv tsev menyuam.

Nws yog ib qho tshuaj estrogen, lossis estrogen receptor agonist, thiab lub hom phiaj lom neeg ntawm estrogen xws li estradiol. Nws yog ib qho hluavtaws derivative ntawm estradiol (ib yam tshuaj estrogen), uas txawv ntawm nws ntau txoj hauv kev. Piv nrog rau estradiol, nws zoo heev txhim kho cov bioavailability thaum noj qhov ncauj, tiv taus ntau dua rau cov metabolism, thiab qhia tau tias muaj txiaj ntsig zoo hauv qee qhov ntawm lub cev xws li lub siab thiab lub tsev menyuam. Cov kev sib txawv no ua rau nws tsim nyog rau cov tshuaj tiv thaiv ntau dua li estradiol, tab sis nws kuj ua rau muaj kev pheej hmoo ntawm thrombosis thiab lwm yam tsis tshua muaj tshwm sim.

Nws tau tsim nyob rau xyoo 1930 thiab tau pib siv tshuaj kho mob hauv xyoo 1943. Nws pib siv tshuaj tiv thaiv kab mob hauv xyoo 1960. Niaj hnub no, nws muaj nyob rau hauv yuav luag txhua qhov sib xyaw ua ke ntawm cov tshuaj tiv thaiv kab mob, thiab nws yuav luag tsuas yog cov tshuaj estrogen siv rau lub hom phiaj no, txawm tias nws tsis yog cov tshuaj estrogen ntau tshaj plaws, nws yog ib qho ntawm lawv.

Ethynyl estradiol ua haujlwm li cas?

Ethynyl estradiol hmoovmuaj cov lus pom zoo thiab tsis zoo rau cov hypothalamus thiab pituitary, thiab ib koob me me tuaj yeem txhawb nqa gonadotropin secretion. Ib koob tshuaj loj tuaj yeem inhibit nws qhov zais cia, yog li inhibiting ovulation ntawm zes qe menyuam thiab ua tiav cov nyhuv antifertility. Nws tuaj yeem txhawb nqa lub caj pas pituitary los ua ke thiab tso tawm gonadotropin, thaum gonadotropin txhawb nqa gonad kom tso cov tshuaj hormones kev sib deev. Kev tso tawm ntawm gonadotropin-tso cov tshuaj hormones hauv hypothalamus yog tswj los ntawm ntau yam, suav nrog cov tshuaj hormones sib deev. Ib leeg-tus neeg sawv cev tuaj yeem ua rau cov tshuaj hormones sib deev hauv kev ncig; Kev siv txuas ntxiv tuaj yeem txo qis- tswj gonadotropin-tso cov tshuaj hormones receptors hauv adenohypophysis, yog li txo qis kev tso tawm ntawm cov tshuaj hormones poj niam txiv neej.

Ethynyl estradiol haum rau qhov twg?

1. Ethynyl estradiol pab estrogen deficiency los kho poj niam gonadal dysfunction, amenorrhea, climacteric syndrome, thiab lwm yam. Rau kev kho mob cancer ntawm lub mis siab (cov poj niam postmenopausal) thiab mob qog noj ntshav prostate siab heev; Ua ke nrog cov tshuaj progestogen, nws tuaj yeem cuam tshuam ovulation thiab tuaj yeem siv los ua cov tshuaj tiv thaiv. Feem ntau yog siv los ua ovulation inhibitor hauv chaw kho mob; Nws kuj tseem siv rau cryptorchidism, androgen ntau dhau, thiab qog pituitary hauv cov menyuam yaus. Kev kuaj mob ntawm hypothalamic-adenohypophysis-gonadal dysfunction tuaj yeem ua raws li kev hloov pauv hauv gonadotropin thiab qib tshuaj hormones.

2. Nws tuaj yeem siv los kho amenorrhea thiab infertility los ntawm hypogonadism vim tsis txaus gonadotropin secretion, thiab infertility tshwm sim los ntawm follicular zes qe menyuam. Cov amenorrhea cuam tshuam txog kev poob phaus yuav tsum tau kho los ntawm kev noj zaub mov ua ntej. Nws kuj yog siv rau kev mob qog nqaij hlav hauv prostate (feem ntau ua ke nrog cyproterone lossis Fluoroformylamine), ncua sijhawm los yog laus dua, thiab endometriosis. Feem ntau yog siv los inhibit zes qe menyuam ovulation thiab ua tiav lub hom phiaj ntawm kev tiv thaiv.

Dab tsi yog qhov tsis zoo ntawm Ethynyl estradiol?

Tsuas yog kev kho mob, cov poj niam uas mob qog noj ntshav yuav tsum tsis txhob siv Ethynyl estradiol vim tias qhov kev mob tshwm sim tuaj yeem ua rau tsis zoo.

Vim tias muaj kev pheej hmoo ntawm venous thromboembolism, cov poj niam pub niam mis tsawg dua 21 hnub tom qab yug me nyuam yuav tsum tsis txhob siv nws. Nws yuav tsum tau tham nrog tus kws kho mob kom siv EE hauv cov poj niam pub niam mis tsawg kawg 21 hnub tom qab yug me nyuam, thiab suav nrog cov ntaub ntawv hais txog qhov zoo, qhov tsis zoo, thiab lwm txoj hauv kev siv nws.

Vim tias muaj kev pheej hmoo ntawm cholestatic hepatotoxicity, feem ntau ntseeg tau tias cov poj niam uas muaj keeb kwm ntawm cholestasis ntawm cev xeeb tub, mob qog nqaij hlav, kab mob siab, thiab tsev neeg tsis zoo hauv cov kua tsib yuav tsum tsis txhob siv cov tshuaj tiv thaiv qhov ncauj uas muaj Ethynyl estradiol.

Qhov hnyav tuaj yeem sib txawv nrog nws qhov ntau npaum li cas thiab txoj kev tswj hwm. Nws cov kev mob tshwm sim dav dav yog tib yam li lwm cov tshuaj estrogen, suav nrog mob lub mis, mob taub hau, ua kua dej (mob plab), xeev siab, kiv taub hau, thiab hnyav nce. Cov tshuaj estrogen ntawm cov tshuaj tiv thaiv qhov ncauj, yuav luag ib txwm, tuaj yeem ua rau mob lub mis thiab puv.

Yuav xaiv cov khoom siv li cas

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Muaj ntau txoj kev xa khoom rau koj xaiv

Tsis lees paub: Cov ntawv luam tawm ntawm lub vev xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.

Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho lossis tiv thaiv kab mob.

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