Dab tsi yog don 6 diazo 5 oxo l norleucine?
Don 6 diazo 5 oxo l norleucine, tseem hu ua Diazooxonorleucine, 6-diazo-5-oxo-l-norleucin, diazo-oxo-norleucine, 6-DIAZO-5-OXO-L-NORLEUCINE, {{10} }DIAZO-5-OXO-NORLEUCINE, L-DON, DON, yog tshuaj tua kab mob cais tawm ntawm Streptomyces thiab glutaminase antagonist nrog IC50 txog li 1 mM rau cKGA (lub raum glutaminase). don 6 diazo 5 oxo l norleucine muaj tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob.
Don 6 diazo 5 oxo l norleucine yog ib qho glutamine antagonist. Vim tias nws cov qauv zoo sib xws nrog glutamine, Don 6 diazo 5 oxo l norleucine tuaj yeem nkag mus rau nws qhov chaw catalytic thiab inhibit nws cov haujlwm los ntawm covalent khi lossis alkylation, uas tuaj yeem cuam tshuam cov haujlwm ntawm ntau yam enzymes raws li glutamine.
Don 6 Diazo 5 Oxo L Norleucine hmoov yog lub teeb xim av hmoov nrog ilv tsw, soluble nyob rau hauv dej, tab sis insoluble nyob rau hauv organic solvents xws li ethanol thiab acetone.
| Khoom npe | rau 6 diazo 5 oxo l norleucine |
| CAS | 157-03-9 |
| Cov mis mos molecular | C6H9N3O3 |
| Molecular hnyav | 171.15 |
| EINECS Number | 251-228-4 |
| Kev cia khoom | -20 degree |
| Melting point | 145 degree |
| Solubility | DMSO (mob, cua sov, kho ultrasonic), dej (muab) |
| Qhov tshwm sim | Lub teeb xim av hmoov |
| Boiling point | 301.12 degree (kev kwv yees ntxhib) |
| Qhov ntom | 1.3994 (zeeg) |
Dab tsi yog pharmacological kev txiav txim ntawm Don 6 Diazo 5 Oxo L Norleucine?
Don 6 Diazo 5 Oxo L Norleucine tsis tau txais kev pom zoo ua tshuaj, tab sis yog nyob rau hauv kev soj ntsuam kev sim ua ke nrog recombinant glutaminase rau kev kho mob ntawm cov qog nqaij hlav sib txawv.
Khoom Specification
| Yam khoom | Specification | Cov txiaj ntsig |
| Yam ntxwv | Lub teeb daj crystalline hmoov | Ua raws |
| Kev txheeb xyuas | A, B ua raws | Ua raws |
| Purity | Ntau dua lossis sib npaug li 98% | 98.45% |
| Xaus | Ua raws li tus qauv hauv tsev | |
Kev npaj ntawm Don 6 diazo 5 oxol norleucine
Don 6 diazo 5 oxo l norleucinetau npaj nrog glutamic acid raws li cov khoom pib, thiab nws cov tshuaj tiv thaiv hluavtaws yog qhia hauv daim duab hauv qab no:
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Daim ntawv thov teb ntawm Don 6 diazo 5 oxo l norleucine yog dab tsi?
Don 6 diazo 5 oxo l norleucineyog ib qho glutamine antagonist uas inhibits qog loj hlob, tab sis tsis tuaj yeem paub qhov txawv ntawm cov hlwb thiab cov qog hlwb. Hauv kev sim tshuaj, nws muaj kev mob plab hnyuv loj thiab cov kev mob tshwm sim, thiab cov neeg mob muaj raws plab, ntuav thiab lwm yam tsos mob. Thaum kawg, qhov kev sim tshuaj tau raug ncua, tab sis nws cov tshuaj tiv thaiv qog tau txais kev saib xyuas ntau dua, thiab tib neeg tau tsom mus rau kev npaj ntawm 6-DIAZO-5-OXO-L-NORLEUCINE prodrugs. Cov tshuaj toxicity ntawm diazooxonorleucine yog los ntawm cov tshuaj pharmacodynamic. Cov qauv kev hloov kho cov qauv tsis tuaj yeem ua tiav cov txiaj ntsig detoxification thaum tswj kev ua tau zoo. Tsuas yog los ntawm kev qhia ib pab pawg neeg uas muaj kev paub txog kev ua haujlwm tshwj xeeb, tsim thiab tsim cov qog-targeted L-6-diazo-5- oxonorleucine prodrug, thiab xaiv xa cov tshuaj mus rau qhov chaw mob, tuaj yeem ua rau muaj kev phom sij rau lub cev. cov hlwb, cov ntaub so ntswg thiab cov khoom nruab nrog cev raug txo kom tsawg, yog li ua rau nws qhov chaw kho mob.
Tsis tas li ntawd, tom qab kev cuam tshuam metabolic nrog Don 6 diazo 5 oxo l norleucine, daim tawv nqaij thickening nyob rau hauv psoriasis lesions tau txo qis, thiab infiltration ntawm lub cev tsis muaj zog. DON tuaj yeem cuam tshuam cov tshuaj tiv thaiv kab mob hauv zos. Nyob rau tib lub sijhawm, L-DON alleviated splenomegaly hauv psoriasis thiab zoo inhibited lub cev tiv thaiv kab mob ntawm psoriasis. Los ntawm kev txheeb xyuas qhov kev qhia ntawm proinflammatory yam nyob rau hauv qhov chaw inflammatory ntawm daim tawv nqaij psoriasis, 6-DIAZO-5-OXO-NORLUCINE kuj inhibited qhov kev qhia ntawm cov noob caj noob ces. Don 6 diazo 5 oxo l norleucine zoo alleviated cov tsos mob ntawm psoriasis.
HNMR atlas of Don 6 diazo 5 oxo l norleucine
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Yuav ua li cas thiab qhov twg yuav Don 6 diazo 5 oxo l norleucine hmoov lag luam wholesale?
Koj tuaj yeem tso siab rau peb qhov kev txiav txim vim tias peb muaj cov ntaub ntawv zoo ntawm kev muag tshuaj raws cai.
Peb ua qhov kev kuaj xyuas ywj pheej ntawm txhua yam khoom thiab tom qab ntawd muag rau peb cov neeg siv khoom hwm.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Tsis lees paub: Cov ntawv luam tawm ntawm lub xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.
Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho, lossis tiv thaiv txhua yam kab mob.
Cim npe nrov: Don 6 diazo 5 oxo l norleucine CAS 157-03-9, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, nyoos hmoov, raw khoom, ua nyob rau hauv Suav teb