Khoom Taw Qhia
6-Diazo-5-oxo-L-nor-Leucine hmoovyog ib qho tshuaj tua kab mob cais tawm ntawm Streptomyces, glutaminase antagonist nrog tus nqi IC50 txog 1 mM rau cKGA (mob raum glutaminase). 6-Diazo-5-oxo-L-norleucine (DON luv luv) yog glutamine antagonist. Vim nws cov qauv zoo sib xws rau glutamine, 6-Diazo-5-oxo-L-norleucine tuaj yeem nkag mus rau nws qhov chaw catalytic thiab inhibit nws cov haujlwm los ntawm covalent khi lossis alkylation. Nws tuaj yeem nthuav dav thiab ua tau zoo inhibit qhov kev ua ntawm ntau yam enzymes nrog glutamine ua lub substrate. Tam sim no, qhov sib xyaw no tab tom kawm txog kev kho mob xws li qog nqaij hlav.
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| 6-Diazo-5-oxo-L-nor-Leucine Duab | 6-Diazo-5-oxo-L-nor-Leucine MF |
Khoom siv
6-Diazo-5-oxo-L-nor-Leucine hmoovyog glutamine antagonist uas inhibits qog loj hlob. Tam sim no, nws cov nyhuv los tiv thaiv qog muaj nuj nqis ntxiv, thiab tib neeg tsom mus rau kev npaj ntawm 6-diazo-5-oxo-L-norleucine prodrugs. Tsuas yog los ntawm kev qhia ib pab pawg neeg uas muaj kev paub txog kev ua haujlwm, tsim thiab tsim cov qog-targeted 6-diazo-5-oxo-L-norleucine prodrugs, thiab xaiv xa cov tshuaj mus rau qhov chaw mob, tuaj yeem ua rau muaj kev phom sij rau cov hlwb ib txwm, cov ntaub so ntswg thiab cov khoom nruab nrog cev raug txo kom tsawg, yog li ua kom nws cov qhov rai kho.
6-Diazo-5-oxo-l-norleucine (DON) yog ib qho glutamine antagonist uas muaj peev xwm tiv thaiv qog noj ntshav; Txawm li cas los xij, nws txoj kev kho mob muaj peev xwm cuam tshuam los ntawm nws cov biodistribution thiab toxicity rau cov ntaub so ntswg ib txwm, tshwj xeeb hauv plab hnyuv (GI) cov ntaub so ntswg. Txhawm rau tiv thaiv DON's toxicity, peb tau tsim cov qog-targeted DON prodrugs tsim los rau circulate inert nyob rau hauv cov ntshav plasma thiab nyiam qhib dua DON hauv qog.
Peb qhov zoo tshaj plaws prodrug 6 (isopropyl 2-}(6-acetamido-2-(adamantane-1-carboxamido)hexanamido)-6-diazo-5-oxohexanoate) pom kev ruaj ntseg hauv plasma, siab, thiab plab hnyuv homogenates tseem tau nkag mus rau DON hauv P493B lymphoma hlwb, nthuav tawm ib 55-fold txhim kho qog cell-rau-plasma piv piv rau DON thiab ua rau muaj qhov tshuaj tiv thaiv ntawm cov cell proliferation.
Khoom Specification
| Yam khoom | Specification | Kev tshwm sim |
| Qhov tshwm sim | Lub teeb daj hmoov | Ua raws |
| Kev txheeb xyuas | Qhov zoo | Ua raws |
| Acidity los yog Alkalinity | Xyuas cov xim ntawm cov tshuaj ntsuam xyuas | Ua raws |
| Tom qab ntxiv cov kev daws teeb meem | ||
| Lumiflavin | Absorbance ntawm filtrate ntawm 440nm | 0.009 |
| Tsis pub tshaj 0.025(USP); | ||
| Absorbance | {{0}}.31 - 0.33 A375nm/A267nm | 0.32/0.38 |
| {{0}}.36 - 0.39 A444nm/A267nm | ||
| Qhov Loj | 100% dhau 60 mesh | Ua raws |
| Kev sib hloov tshwj xeeb | Nruab nrab ntawm -115 degree thiab -135 degree (EP/BP/USP) | 121 degree (USP) |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.5% | 0.80% |
| Hnyav Hlau | <10ppm | Ua raws |
| Residue ntawm Ignition | Tsawg dua los yog sib npaug rau 0.03%(USP) | 0.10% |
| Organic Volatile Impurities | Method IV<467>(USP) | Ua raws |
| Assay (ntawm qhuav hauv paus) | 98. 0% - 102.0% (USP) | 99.85% |
| Xaus | Ua raws li tus qauv kev lag luam | |
Yuav Ua Li Cas Kom Tau Txais Cov Qauv6-Diazo-5-oxo-L-nor-Leucine hmoov?
Txais tos xa ib qho kev nug rausunny@faithfulbio.comtxhua lub sijhawm rau tus qauv dawb yog tias koj xav tau API6-Diazo-5-oxo-L-nor-Leucine hmoov.
Qhov zoo tshaj plaws 6-Diazo-5-oxo-L-nor-Leucine hmoov Chaw tsim tshuaj paus Thiab tsum
Faithfulbio muaj kev paub dhau los hauv kev xa tawm cov ntaub ntawv raw thiab tau tsim kev sib raug zoo thiab kev koom tes ntev nrog peb cov neeg siv khoom. Peb ib txwm muab cov khoom zoo thiab kev pabcuam ua ntej. Yog tias koj muaj cov khoom siv raw khoom xav tau, thov hu rau peb. Peb tuaj yeem lees paub qhov kev txiav txim nrog koj raws li koj qhov yuav khoom ntau. Peb kuj txhawb peb txoj kev koom tes thawj zaug pib los ntawm cov qauv. Tsis tas li ntawd, peb txoj kev thauj mus los sai thiab nyab xeeb kuj ua rau koj tshem tawm cov teeb meem ntawm kev lis kev cai.
Peb muaj kev ntseeg siab ntawm peb cov khoom zoo, tab sis yog tias muaj teeb meem tom qab muag, peb yuav teb sai li sai tau thiab daws lawv nrog koj txoj hauv kev zoo tshaj plaws.
Vim Li Cas Xaiv Faithfulbio6-Diazo-5-oxo-L-nor-Leucine hmoov?
Faithfulbio tshwj xeeb hauv6-Diazo-5-oxo-L-nor-Leucine hmoovrau ntau xyoo, peb muab cov khoom ntawm tus nqi sib tw, thiab peb cov khoom yog qhov zoo tshaj plaws, vim tias peb nruj heev hauv cov khoom tsim thiab kev sim, thiab muaj kev ua tiav thiab paub tab. Tsis tas li ntawd, peb cov neeg ua haujlwm Cov lus hais rau cov khoom muaj kev sib tw heev.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
ua siab zoo ceeb toom:Siv6-Diazo-5-oxo-L-nor-Leucine hmoovrau kev tshawb fawb nkaus xwb. Txhua lub tebchaw muaj kev pheej hmoo. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv. Tsis tas li ntawd, cov lus piav qhia saum toj no ntawm qhov sib xyaw yog los ntawm cov ntaub ntawv online. Yog tias muaj kev ua txhaum cai, thov hu rau peb kom tshem tawm.
Qhov Yuav Yuav 6-Diazo-5-oxo-L-nor-Leucine hmoov?
Cia li xa email rausunny@faithfulbio.com, lossis xa koj qhov yuav tsum tau ua hauv daim ntawv hauv qab, peb muaj kev pabcuam txhua lub sijhawm!
Cim npe nrov: 6-diazo-5-oxo-l-nor-leucine cas 157-03-9, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, rau muag, nyob rau hauv Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Suav teb