Carbidopa Monohydrateyog AADC inhibitor. Thaum ua ke nrog levodopa, nws tuaj yeem txo cov decarboxylation ntawm levodopa hauv cov ntaub so ntswg peripheral, ua kom levodopa ntau dua mus txog substantia nigra striatum thiab ua lub luag haujlwm, thiab txhim kho cov nyhuv ntawm levodopa. Kev sib xyaw ua ke ntawm ob tuaj yeem txo qhov koob tshuaj ntawm levodopa, txo qis lossis tiv thaiv cov tshuaj lom thiab kev phiv ntawm levodopa, thiab txo lub sijhawm kom ua tiav cov nyhuv curative thaum pib kho.
Carbidopa monohydrate yog dab tsi?
Carbidopa yog ib hom dawb fluffy siv lead ua, yuav luag tsis muaj ntxhiab. Muab xam raws li cov teeb meem tsis muaj dej, cov ntsiab lus ntawm c10h14n2o4 yuav tsum tsis pub tsawg dua 99.0 feem pua. Carbidopa muaj zog inhibitor ntawm peripheral Doba decarboxylase. Nws yog ib qho tseem ceeb adjuvant tshuaj, thiab nws yog siv tsis tau siv nws ib leeg. Nws tuaj yeem txhim kho qhov ua tau zoo ntawm cov tshuaj sab hnub poob uas cuam tshuam, yooj yim tawg los ntawm cov ntshav thaiv thiab kho cov paj hlwb puas. Kev kov yeej cov txiaj ntsig tsis zoo, kho cov tsos mob tab sis tsis yog lub hauv paus ua rau, thiab ua kom tus mob zoo dua ib kauj ruam.
Pharmacological hauv paus ntawm levodopa thiab carbidopa ua ke? Yuav siv li cas ua ke?
Carbidopa tsis tuaj yeem nkag mus rau cov ntshav tsis txaus siab. Nws yog siv los ua ib qho tseem ceeb adjuvant ntawm levodopa nyob rau hauv kev kho mob ntawm tremor paralysis. Thaum ua ke nrog levodopa, nws tuaj yeem txo qhov decarboxylation ntawm levodopa nyob rau hauv periphery thiab txo nws cov kev mob tshwm sim los ntawm inhibiting peripheral dobba decarboxylase, thiab txhim kho cov nyhuv curative ntawm levodopa los ntawm kev nce cov concentration ntawm DA hauv lub hlwb.
Levodopa hloov mus rau hauv dopamine tom qab dhau los ntawm cov ntshav - lub hlwb thaiv thiab ua ncaj qha ntawm presynaptic membrane thiab postsynaptic membrane ntawm neurons nyob rau hauv daim ntawv ntawm neurotransmitters. Txawm li cas los xij, levodopa yog yooj yim inactivated los ntawm decarboxylase sab nraum lub hlwb. Carbidopa muaj ib tug muaj zog inhibitor ntawm peripheral dobba decarboxylase, uas yuav ua rau kom cov kev siv ntawm levodopa sab nraum lub hlwb thiab txhim khu cov nyhuv ntawm cov tshuaj.
Nws cov txheej txheem ntawm kev ua haujlwm zoo ib yam li DOPA hydrazine ntsiav tshuaj (medoba). Benzylhydrazine muaj nyob rau hauv DOPA hydrazine kuj yog ib tug decarboxylase inhibitor, uas yog siv los txhim kho kev siv ntawm levodopa.Nyob rau hauv lub tsev kho mob, carbidopa thiab levodopa feem ntau yog npaj rau compound npaj nyob rau hauv qhov ratio ntawm 1:10 los yog 1: 4.
Kev tsis zoo ntawm carbidopa?
1. Nws yog qhov tsawg heev los siv ib leeg. Thaum ua ke nrog levodopa, xeev siab thiab ntuav tuaj yeem tshwm sim. Cov kev phiv tshwm sim los ntawm levodopa, xws li kev txav mus los thiab kev puas siab puas ntsws, zoo li tshwm sim ua ntej. Nws feem ntau tuaj yeem ua rau muaj kev nyuaj siab ntxhov plawv thiab tsis tuaj yeem txav ntawm lub ntsej muag, tus nplaig, sab sauv thiab txhais tes.
2. Tej yam tshwm sim tsis zoo xws li dyskinesia thiab hallucinations.