PNC-27 Taw qhia
PNC-27: CAS 1159861-00-3 yog ib qho khoom siv hluavtaws peptide compound nrog cov mis molecular C₁₈₈H₂₉₃N₅₃O₄₄S. Nws yog feem ntau siv los ua tus qauv qauv lossis reagent hauv kev tshawb fawb tshawb fawb rau kev siv hauv chav kuaj. PNC-27 PN5 yog qhov tseem ceeb ntawm peptide tsim, nrog rau nws cov kab ke tshwm sim los ntawm qhov chaw uas p53 protein khi rau HDM-2, thiab nws txuas nrog cov txheej txheem nkag mus rau hauv daim nyias nyias. Yog li ntawd, nws yog feem ntau siv nyob rau hauv kev tshawb fawb los tshawb txog lub hom phiaj mechanism tiv thaiv lub siab qhia ntawm HDM-2 nyob rau saum npoo ntawm tej qog hlwb. Tam sim no,PNC27Feem ntau muaj nyob rau hauv kev tshawb fawb tshawb fawb reagent kev lag luam, thiab nws cov ntawv thov thaj chaw feem ntau yog nyob rau hauv kev tshawb fawb yooj yim thiab thaum ntxov hauv vitro thwmsim, los kawm txog nws lub peev xwm rau kev xaiv kev lees paub thiab kev puas tsuaj ntawm cov qauv cell membrane.
Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm PNC-27?
PNC-27 yog qhov sib txawv ntawm txoj hauv kev ib txwm muaj uas tso siab rau txoj hauv kev apoptotic ntawm cov hlwb.
Nws mechanism ntawm kev txiav txim feem ntau yog nyob rau hauv ob yam:
Thawj kauj ruam yog kev lees paub thiab kev khi
Muaj ib lub npe nyob rau hauv ib theem ntawm PNC-27 uas ua raws li kev khi ntawm p53 protein rau HDM-2. Cov qauv no tso cai rau nws kom meej meej "txheej txheem" ntawm qhov txawv txav ntawm HDM-2 protein ntau ntawm cov qog nqaij hlav qog nqaij hlav. Cov ntsiab lus ntawm HDM-2 nyob rau hauv ib txwm cell membrane yog tsawg heev, yog li nws yeej tsis quav ntsej cov hlwb li qub, uas yog vim li cas nws thiaj li xaiv tau los.
Qhov thib ob theem yog pore tsim thiab lysis
Tom qab khi,PNC27yuav nkag mus rau hauv lub cell membrane thiab tsim transmembrane pores ntawm daim nyias nyias. Thaum cov pores tau tsim, cov ions thiab cov ntsiab lus hauv lub cell yuav tawm sai sai, ua rau muaj kev cuam tshuam hauv osmotic siab, thiab thaum kawg ua rau necrotic lysis thiab tuag ntawm cov qog nqaij hlav cancer. Cov kev tshawb fawb tau pom ncaj qha rau cov qauv pore siv immunoelectron microscopy, qhia tias PNC-27 thiab HDM-2 tau teem rau hauv qhov sib piv 1: 1 nyob ib ncig ntawm qhov pores.
Lub ntsiab lus tseem ceeb tshaj plaws yog tias qhov txheej txheem no tsis tso siab rau kev ua haujlwm ntawm p53. Txawm hais tias cov qog hlwb muaj p53 tsis txaus lossis hloov pauv,PNC27tseem tuaj yeem siv nws cov nyhuv. Nws ncaj qha lub hom phiaj HDM-2 ntawm lub cell membrane, bypassing lub complex apoptotic signaling txoj kev nyob rau hauv lub cell.
PNC-27 tsuas paub txog cov qog nqaij hlav cancer. Qhov no tau txheeb xyuas li cas hauv kev tshawb fawb?
Qee cov kev tshawb fawb tau rho tawm cov txheej txheem membrane ntawm cov qog nqaij hlav qog nqaij hlav thiab cov hlwb ib txwm rau kev sim, thiab pom tias theem ntawm HDM-2 ntawm cov qog nqaij hlav qog nqaij hlav yog plaub mus rau cuaj npaug ntau dua li ntawm cov hlwb qub. Cov pov thawj ncaj qha ntxiv los ntawm qhov kev sim "rov qab hloov kho": cov hlwb ib txwm muaj qhov tsis zoo rauPNC27, tab sis thaum cov kws tshawb fawb tau qhia txog ib ntu uas ua rau HDM-2 nyob rau hauv thaj chaw ntawm daim nyias nyias rau hauv cov hlwb, cov hlwb yav dhau los "kev nyab xeeb" kuj tau pib degraded los ntawm PNC-27; conversely, yog hais tias tus qhia HDM-2 tsis muaj p53 binding domain, cov nyhuv no yuav tsis tshwm sim. Ob pawg ntawm cov ntaub ntawv no ruaj khov tsim qhov tseeb tias "kev khi rau HDM-2 ntawm daim nyias nyias yog qhov tsim nyog rau kev tua". Tsis tas li ntawd, immunoelectron microscopy kuj tau ntes cov duab uas qhia tias PNC-27 thiab HDM-2 tau npaj kwv yees li ib-rau-ib ncig ntawm lub pore channel, muab lwm txheej pov thawj ntawm cov txheej txheem.
Specification
| Cov khoom kuaj | Specification | Kev Xeem |
| Qhov tshwm sim | Dawb hmoov | Ua raws |
| Tus kheej (MS) | Raws li theoretical molecular hnyav | Ua raws |
| Purity (HPLC, 214nm) | Ntau dua lossis sib npaug li 98.0% | 98.60% |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 8.0% | 4.20% |
| Cov ntsiab lus Acetate | 5.0 ~12.0% | 7.80% |
| Cov ntsiab lus Peptide | Ntau dua lossis sib npaug li 80.0% | 84.50% |
| Endotoxin | Tsawg dua lossis sib npaug li 1.0 EU / mg | 0.4 EU / mg |
| Hnyav Hlau | Tsawg dua lossis sib npaug li 10 ppm txhua | <10 ppm |
| Pb / As / Cd / Hg | tag nrho dhau | |
| Tag nrho Microbial suav | Tsawg dua lossis sib npaug li 100 CFU / g | <10 CFU/g |
| Poov & Pwm | Tsawg dua lossis sib npaug li 10 CFU / g | <10 CFU/g |
Nyem email:sales6@faithfulbio.comLos yog WhatsApp:+86 17782780648
Muaj ntau txoj kev xa khoom rau koj xaiv
| Tsheb thauj mus los | Shipping txoj kev | Cargo hnyav xav tau | Qhov zoo |
| 3-7 hnub | DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, UPS, USPS, FedEx, TNT, EMS |
Haum rau qis dua 50kg. International qhov rooj rau qhov rooj nthuav qhia |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, thiab cov neeg siv khoom hauv Tebchaws Europe thiab Asmeskas tuaj yeem txaus siab xa khoom ncaj qha los ntawm ob qhov chaw no. |
| 7-15 hnub | Los ntawm Cua | Haum rau ntau tshaj 50kg. ceev thiab pheej yig dua rau kev txiav txim loj |
|
| 15-60 hnub | Los ntawm Hiav Txwv | Haum rau ntau tshaj 500kg. Kev xa khoom pheej yig tshaj plaws |
Peb lub zog:
Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub Hoobkas thiab chaw kuaj hauv Suav teb, Peb lub tuam txhab tuaj yeem muabPNC27thiab lwm yam ntawm tus nqi zoo dua. Yog tias koj txaus siab, thov sau ib tsab ntawv.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj hauv kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.
FAQ:
Q1: PNC-27 puas muaj kev cuam tshuam rau lub cev li qub?
Tsis muaj qhov cuam tshuam tseem ceeb tau pom hauv vitro thiab hauv kev sim tsiaj vim tias theem ntawm HDM-2 ntawm cov cell membranes qis heev.
Q2: Puas muaj kev sib txuas ntawm PNC-27 thiab Paclitaxel?
Yog lawm. Hauv cov qauv qog nqaij hlav zes qe menyuam, nws tau pom tias kev sib xyaw ntawm ob qho tib si muaj kev sib koom ua ke. PNC-27 tuaj yeem tsom cov hlwb uas muaj sia nyob tom qab kev kho mob tom kawg.
Q3: Rau hom mob qog noj ntshav twg yog PNC-27 feem ntau kawm?
Mob ntshav qab zib myeloid leukemia, mob qog nqaij hlav pancreatic, mob qog noj ntshav zes qe menyuam, mob qog noj ntshav mis, melanoma, thiab lwm yam.
Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.
Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais.
Nyem email:sales6@faithfulbio.comLos yog WhatsApp:+86 17782780648
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