Idra-21 Cognitive hmoovyog ib qho zoo allosteric regulator ntawm AMPA receptor thiab benzothiadiazole derivative. Nws yog chiral molecule uas (ntxiv rau ) - IDRA-21 yog daim ntawv nquag.
IDRA-21 coj li cas hauv kev sim tsiaj?
Hauv kev kawm txog kev txhawb nqa kev txawj ntse hauv cov tsiaj,IDRA-21 hmoovho txhim kho lub peev xwm ntawm kev kawm thiab kev nco. Hauv kev thim rov qab kev paub tsis txaus ntseeg tshwm sim los ntawm kev siv sijhawm ntev - siv alprazolam lossis scopolamine, nws yog li 10-30 npaug zog dua aniracetam. Qhov tseem ceeb tshaj plaws yog nws cov tshuaj metabolism hauv lub sijhawm: nws tau kawm los tsim cov teebmeem ntev txog 48 teev tom qab kev tswj hwm ib zaug. Cov kws tshawb fawb hais tias cov txheej txheem ntawm qhov kev cuam tshuam no yuav yog los ntawm kev txhawb nqa mus ntev ntawm lub hlwb synapses.
Dab tsi yog cov txheej txheem ntawm kev paub txog kev tshawb nrhiav tshuaj? Ua li casIDRA-21yug?
In 1990, neuroscientist Eric Kandel discovered a brain chemical called cyclic adenosine monophosphate response element-binding protein (CREB), which is a key factor in memory formation. In 1994, neuroscientists Tim Tully and Jerry Yin adjusted the way CREB works in a fruit fly. When learning new habits, fruit flies with enhanced CREB were 10 times faster than their unchanged counterparts. Later, other researchers got the same results in mice. In 1999, Qian Zhuo, a neuroscientist at Princeton University, created a mouse with more pairs of NR2B genes, which can coordinate the activity of synaptic receptors in the brain. In memory and learning tests, NR2B enhanced mice performed five times better than unmodified mice. After 2000, many new pharmaceutical companies competed to apply these findings to humans. Both memory pharmaceutical and helikongshan medical are conducting clinical trials of drugs related to CREB. Another COLTEX pharmaceutical company is developing a brain chemical called ampakine to achieve similar effects through another neural pathway. Among so many research institutions, Jingsi pharmaceutical （Abbreviation: IDRA） has developed IDRA-21 through step-by-step analogy research. At the same time, there are many sister products of this product, which have been eliminated for various reasons.