Prostaglandin E1yog lub ntsiab tseem ceeb ntawm alprostadil, nyob rau hauv uas taum roj, concentrated Vaseline, fatty acids, thiab txhaj tshuaj kais dej ntxiv. Alprostadil yog cov tshuaj kho mob rau platelet aggregation inhibition. Nws yog ib tug dawb milky kua. Dab tsi yog qhov ua tau zoo ntawm kev txhaj tshuaj alprostadil?
Clinically, yuav siv cov tshuaj alprostadil li cas?
Alprostadil yog cov tshuaj siv dav hauv cov chaw kho mob txhawm rau txhim kho microcirculation. Nyob rau tib lub sijhawm, nws kuj yog ib qho tshuaj uas muaj ntau yam tsis zoo, feem ntau yog phlebitis. Hauv kev siv tshuaj kho mob, nws pom tias qee cov neeg mob tau cuam tshuam kev siv tshuaj vim qhov sib txawv ntawm phlebitis, uas cuam tshuam rau kev kho mob.
Tam sim no, alprostadil txhaj tshuaj siv hauv kev kho mob feem ntau yog 10ug yaj hauv 100ml ntawm 0.9 feem pua sodium chloride txhaj, uas tsis yog raws li cov cai ntawm phau ntawv. Cov kev cai rau kev siv thiab kev txhaj tshuaj alprostadil yog: ib hnub ib zaug rau cov neeg laus, 1-2ml (alprostadil 5-10ug) ntxiv rau 10ml ib txwm saline (los yog 5 feem pua qabzib) rau kev txhaj tshuaj maj mam, lossis ncaj qha mus rau hauv lub lauj kaub me me kom qeeb. tso dej drip. Cov ntaub ntawv ntsig txog tau ua pov thawj tias txoj kev tswj hwm ntawm alprostadil yog ze ze rau nws cov phlebitis.
Cov nyhuv thiab kev ua haujlwm ntawm kev txhaj tshuaj alprostadil?
Kev txhaj tshuaj Alprostadil yog ib hom tshuaj suav tshuaj npaj ntawm alprostadil rau kev txhaj tshuaj nrog liposome raws li kev kho tshuaj plasmid cab kuj. Vim lub encapsulation ntawm liposomes, prostaglandin E1 tsis yooj yim rau degrade. Nws muaj cov yam ntxwv ntawm lub hom phiaj uas yooj yim kis mus rau cov hlab ntsha puas, thiaj li muab kev ua si tag nrho rau cov nyhuv ntawm cov hlab ntsha softening thiab inhibiting platelet coagulation.
Kev txhaj tshuaj Alprostadil tuaj yeem siv los kho cov pob txha caj dab uas tshwm sim los ntawm diffuse aortic obliterans (venous thromboangiitis obliterans, arteriosclerosis obliterans) thiab limb so mob los ntawm kev cuam tshuam ntawm microvascular circulatory system, thiab txhim kho kev cuam tshuam ntawm cov hlab plawv thiab cerebrovascular microcirculation. Nws feem ntau yog siv los ua kev kho mob antithrombotic tom qab visceral organ transplantation los inhibit thrombosis hauv cov hlab ntsha transplanted. Tsis tas li ntawd, rau cov menyuam yaus uas muaj kab mob hauv lub plawv thiab patent ductus arteriosus, nws tuaj yeem txo qis hypoxemia thiab tswj cov hlab ntsha mos kom tos kev phais.
Kev txhaj tshuaj Alprostadil tsis haum rau cov neeg mob uas muaj lub plawv tsis ua haujlwm hnyav (lub plawv tsis ua haujlwm), glaucoma lossis siab intraocular siab, thiab yav dhau los cov teeb meem ntawm plab hnyuv.
Qhov txawv ntawm prostaglandin E1 thiab E2 yog dab tsi?
Prostaglandin E1 yog prostaglandin, uas yog cov khoom siv bioactive uas tuaj yeem tsim los ntawm ntau lub cev ntawm tib neeg lub cev. Piv txwv li, prostaglandin E1 tuaj yeem tsim hauv lub ntsws, hlwb, lub plawv, lub raum, thiab plab hnyuv. Prostaglandin E1 tau pom thawj zaug hauv cov phev uas tsim los ntawm cov hlab ntsha hauv lub cev. Nws feem ntau yog vasodilation. Yog li ntawd, yog hais tias nws yog siv nyob rau hauv qhov chaw mos, nws yuav ua rau penile vasodilation, cavernous congestion, thiab ruaj penile erection, yog li nws yog feem ntau siv nyob rau hauv cov neeg mob impotence, thiab cov nyhuv yog zoo heev; Siv rau cov neeg mob thrombosis, nws tuaj yeem nthuav cov hlab ntsha thiab pab txo cov tsos mob ntawm thrombosis. Prostaglandin E2 (PGE2), tseem hu ua dinoprostone, yog lub ntuj prostaglandin uas tuaj yeem siv los ua tshuaj. PGE2 yog ib hom tshuaj ntawm tsev neeg oxytocin. Kev khi thiab ua kom cov prostaglandin E2 receptor ua rau qhib thiab muag ntawm lub ncauj tsev menyuam thiab nthuav cov hlab ntsha. Nws yog ib qho ncaj qha vasodilator uas ua kom cov leeg du thiab inhibits qhov tso tawm ntawm norepinephrine los ntawm cov sympathetic terminals.
in summary: Prostaglandin E1 is mainly used for erectile dysfunction. It is a local drug. After use, it can promote the blood supply to the cavernous body. It can improve the patient's impotence and premature ejaculation. Prostaglandin E2 is mainly used to induce labor, which can soften the uterine orifice and promote uterine contraction. The specific dosage needs to be determined according to the individual's condition, and it cannot be used blindly without permission.