Gaoben lactone yog tus sawv cev tshaj plaws ua haujlwm monomer tivthaiv hauv Angelica sinensis thiab Ligusticum chuanxiong. Nws tau raug pov thawj tias muaj ntau yam tshuaj muaj txiaj ntsig, suav nrog kev tiv thaiv neuroprotection, tiv thaiv -inflammatory, antioxidant, txhim kho lub plawv tsis ua hauj lwm thiab daim siab lipid metabolism, thiab txhawb nqa ntawm angiogenesis. Lub mechanism ntawm qhov kev txiav txim yog maj mam txav los ntawm ib tug phenomenon mus rau ib tug pathway tsom xam.
🌿 keeb kwm yav dhau: Nws tsis yog tsuas yog lub hauv paus ntawm "Danggui tsw", tab sis kuj yog molecular code ntawm ntau txhiab xyoo ntawm kev paub.
Angelica sinensis thiab Ligusticum chuanxiong belongs rau tsev neeg Umbelliferae thiab yog cov feem ntau siv tshuaj suav tshuaj tshuaj ntsuab los txhawb cov ntshav ncig thiab tshem tawm cov ntshav stasis. Phau ntawv qub "Shennong Bencao Jing" hais tias Angelica sinensis "feem ntau yog hnoos tawm tsam sab sauv qi, ntxuav cov malaria sov thiab txias hauv daim tawv nqaij, ua rau cov poj niam ua rau lawv lub cev tuag, thiab muaj ntau yam mob qog noj ntshav thiab mob kub." Lub "Compendium of Materia Medica" qhuas Chuanxiong rau "nce lub taub hau, nqis dej hiav txwv, thiab qhib nruab nrab rau stagnation." Qhov ob feem ntau siv ua ke los tswj kev coj khaub ncaws, txo qhov mob, ua kom ntshav khiav, thiab tshem tawm cov khoom lag luam.
Tab sis nws tsis yog kom txog rau thaum nruab nrab mus rau lig xyoo pua 20th uas cov kws tshawb fawb cais cov khoom tseem ceeb,Ligustilide, los ntawm nws cov roj volatile. Nws yog ib tug natural compound ntawm phthalein chav kawm ntawv, nrog ib tug molecular mis ntawm C ₁₂ H ₁₄ O ₂ thiab molecular hnyav ntawm 190.24. Nws muaj nyob rau hauv ob configurations, (Z) - thiab (E) -, ntawm cov uas * * (Z) - Ligustride yog lub ntuj dominant configuration nrog muaj zog lom kev ua si * * 5. Nws tsis yog tsuas yog lub ntsiab qhov chaw ntawm lub cim aroma ntawm Angelica sinensis (zoo ib yam li fennel los yog iab ntawm nws cov khoom siv niaj hnub), tab sis kuj tseem muaj cov tshuaj lom neeg. Nws yog ib qho tsim nyog sau cia tias nws tsis muaj nyob hauv kev sib cais: Angelica sinensis tseem muaj cov khoom sib xyaw ua ke xws li ferulic acid, coumarin, thiab polysaccharides; Chuanxiong, ntawm qhov tod tes, coexists nrog ligustilide thiab ligustilide, tsim ib tug natural compound nyhuv nrog ntau lub hom phiaj thiab txoj kev.
❤️Chemical yam ntxwv ntawm ligustilide
Cov mis mos molecular ntawm Ligustride isC12H14O2C12H14O2 Structurally, nws muaj ib tug tseem ceeb qauv ntawm isobenzofuranone, uas muaj xws li ib tug benzene nplhaib thiab ib tug tsib membered lactone nplhaib txuas nrog lub nplhaib benzene. Cov qauv no ua rau nws muaj qee qhov kev ruaj ntseg, thaum tseem cuam tshuam rau nws cov khoom siv tshuaj lom neeg thiab kev ua haujlwm lom neeg.
Ntawm cov qauv ntawm isobenzofuranone, muaj ib pab pawg butenyl txuas ntawm txoj hauj lwm 3. Lub xub ntiag ntawm pawg butyl no muab ligustilide ib co℃ntawm unsaturation, uas ua rau nws muaj feem xyuam rau cov tshuaj tiv thaiv xws li tshuaj tiv thaiv ntxiv. Lub caij no, cov qauv spatial thiab hluav taws xob los ntawm pawg butyl tuaj yeem cuam tshuam rau lub cev thiab tshuaj lom neeg ntawm tag nrho cov molecule.
Muaj cov stereoisomers sib txawv ntawm ligustilide, xws li (Z) - ligustilide thiab (E) - ligustilide. Lawv qhov sib txawv yog nyob rau hauv cov kev teeb tsa sib txawv ntawm cov pab pawg butyl, uas tuaj yeem ua rau muaj qhov sib txawv ntawm lawv lub cev, kev ua haujlwm tshuaj lom neeg, thiab kev ua haujlwm lom neeg vim qhov sib txawv ntawm lawv peb - qauv qauv. Piv txwv li, kev teeb tsa sib txawv ntawm ligustilide tuaj yeem pom cov teebmeem sib txawv ntawm cov kab mob tua kab mob, tiv thaiv - mob, thiab lwm yam dej num lom neeg.
Zuag qhia tag nrho, cov qauv tshuaj tshwj xeeb ntawm ligustilide yog lub hauv paus rau nws cov haujlwm lom neeg ntau yam, uas yog qhov tseem ceeb rau kev kawm ntxiv txog nws cov tshuaj pharmacological thiab tsim cov tshuaj muaj feem xyuam.
🧪 Cov txiaj ntsig tseem ceeb: Los ntawm kev sim ntawm tes mus rau cov qauv tsiaj, cov ntaub ntawv pov thawj tau nce zuj zus
Cov kev tshawb fawb tam sim no tau qhia txog qhov muaj peev xwm cuam tshuam ntawm ligustilide hauv ntau qhov chaw kab mob loj. Cov hauv qab no yog muab faib thiab tsim los ntawm kev ua haujlwm qhov ntev, nrog rau kev tsom mus rau cov txheej txheem thiab cov pov thawj kev sim:
✅Neuroprotection thiab kev txawj ntse txhim kho: combating hlwb laus thiab vascular dementia
Cov kab mob tseem ceeb ntawm cov kab mob neurodegenerative xws li Alzheimer's disease (AD) thiab vascular dementia (VaD) suav nrog oxidative stress, mitochondrial puas, endoplasmic reticulum stress, thiab neuroinflammation. Ntau qhov kev tshawb fawb tau lees paub tias ligustilide tuaj yeem tiv thaiv kev tiv thaiv los ntawm kev tswj hwm cov cim tseem ceeb
Hauv cov qauv vascular dementia nas, Ligustride tau txhim kho kev kawm thiab kev nco tsis zoo, thiab nws cov txheej txheem tau qhia meej meej rau kev ua kom txoj hauv kev SIRT1 / IRE1 / XBP1s, inhibiting CHOP mediated apoptosis, thiab yog li txo qis kev ntxhov siab endoplasmic reticulum;
Nyob rau hauv vitro neuronal hypoxia / reoxygenation qauv, nws tuaj yeem txo mitochondrial cytochrome C tso tawm, inhibit caspase-3 ua kom, thiab txhim kho cell ciaj sia;
Nws muaj peev xwm los tiv thaiv neuroinflammatory muaj peev xwm kuj tau lees paub: los ntawm inhibiting NF - κ B txoj hauv kev, nws txo qis kev tso tawm ntawm pro- mob xws li TNF - , IL-1 , thiab TSIS TAU los ntawm microglia.
Cov ntsiab lus: Rau cov neeg uas muaj kev txhawj xeeb txog kev noj qab haus huv ntawm lub hlwb, tiv thaiv kev qaug zog, thiab ncua kev paub txog kev poob qis, ligustilide muab kev cuam tshuam kev noj haus tshiab raws li mitochondrial homeostasis thiab endoplasmic reticulum tshuav nyiaj li cas.
✅ Kev tiv thaiv kab mob plawv: los ntawm kev txhim kho lub plawv tsis ua hauj lwm mus rau kev txhawb nqa angiogenesis
Lub plawv tsis ua hauj lwm (HF) yog qhov kawg theem ntawm ntau yam kab mob hauv lub plawv, tus cwj pwm los ntawm myocardial remodeling thiab microcirculatory disorders. Nyob rau hauv xyoo tas los no, cov kev tshawb fawb tau pom tias ligustilide tsis tuaj yeem txhim kho lub plawv, tab sis kuj kho cov hlab ntsha los ntawm "qhov chaw":
Pab pawg Jilin University tau lees paub nyob rau hauv tus qauv nas ntawm lub plawv tsis ua haujlwm vim los ntawm coronary artery ligation uas Ligustride tuaj yeem ua rau muaj qhov nce ntawm sab laug ventricular ejection feem (LVEF) thiab ua kom luv sab laug ventricular kawg diastolic txoj kab uas hla (LVEDD); Cov kev tshawb fawb ntxiv tau pom tias nws txhawb kev nce hauv myocardial capillary ceev thiab txhim kho myocardial oxygen mov los ntawm upregulating PKD1 / HIF-1 / VEGF signaling axis;
Nyob rau hauv lub raum ischemia-reperfusion (I/R) tus qauv raug mob, nws tuaj yeem txo qhov kev puas tsuaj mitochondrial, txo oxidative kev nyuaj siab, tiv thaiv lub raum cov ntaub so ntswg, thiab indirect tswj lub plawv system homeostasis.
Cov ntsiab lus: Rau nruab nrab- cov neeg laus thiab cov neeg laus, cov tib neeg noj qab haus huv, lossis cov neeg muaj kev pheej hmoo plawv plawv, cov qauv siv ob npaug ntawm "kev txhawb zog lub plawv thiab txhawb cov hlab ntsha" yog raws li lub tswv yim ntawm "tiv thaiv kab mob ua ntej nws tshwm sim".
✅ Kev tiv thaiv kab mob thiab kev tiv thaiv kab mob: dhau "txo o thiab txo qhov mob"
Kev lig kev cai, nws ntseeg tau tias Angelica sinensis thiab Ligusticum chuanxiong txhawb cov ntshav ncig thiab tshem tawm cov ntshav stasis, uas sib raug rau cov tshuaj tiv thaiv - mob ntawm cov tshuaj niaj hnub. Cov tshuaj tiv thaiv -inflammatory mechanism ntawmligustilidetau nkag mus rau hauv qib hloov molecular:
Rau macrophages thiab microglia, nws txo qis kev qhia ntawm iNOS, COX-2, TNF -, thiab lwm yam los ntawm thaiv NF - κ B nuclear translocation;
Nyob rau hauv cov qauv ntawm daim siab fatty acids, nws lub hom phiaj ntawm inhibition ntawm RXFP1 receptors, uas nyob rau hauv lem inhibits lub activation ntawm NLRP3 inflammasomes thiab tsim ntawm neutrophil extracellular ntxiab (NETs), yog li suppressing lub cascade ntawm daim siab mob los ntawm qhov chaw;
Tsis tas li ntawd, nws tseem muaj cov tshuaj tua kab mob thiab tshuaj tua kab mob (antifungal qhab nia ntawm 5.6), nthuav nws cov peev txheej hauv kev kis kab mob.
Cov ntsiab lus: Cov qauv "sab sauv lub hom phiaj kev cuam tshuam" no yog qhov txawv ntawm cov tshuaj siv tshuaj uas yooj yim tshem tawm cov tsos mob thiab tsim nyog rau lub sijhawm ntev - kev tswj hwm thiab kev tswj xyuas mob ntev.
✅ Metabolic regulation: daim siab tiv thaiv, lipid regulation, anti rog degeneration
Cov kab mob tsis muaj dej cawv fatty siab (NAFLD) thiab cawv steatosis (ASH) tau dhau los ua lub nra hnyav thoob ntiaj teb. Gaoben lactone nthuav qhia meej metabolic kev cuam tshuam muaj peev xwm:
Nyob rau hauv tus qauv NAFLD nas, nws txo cov fatty acid uptake thiab triglyceride synthesis los ntawm inhibiting kev qhia ntawm FATP5 thiab DGAT noob;
Nyob rau hauv tus qauv ntawm daim siab steatosis, nws bidirectionally tswj cov lipid metabolism proteins PPAR (txhawb fatty acid oxidation) thiab SREBP1 (inhibiting rog synthesis), thiab synergistically inhibits lub RXFP1-NLRP3 axis, ua tiav ib tug dual txoj kev ntawm "qhov hnyav" +
Cov kev tshawb fawb ua ntej kuj tau qhia tias nws muaj peev xwm txo cov ntshav qab zib thiab txhim kho cov tshuaj insulin, uas yog qhov zoo sib xws nrog cov kev paub ntawm Angelica sinensis hauv kev kho mob ntshav qab zib ib txwm muaj.
Summary: Nws yog ib tug natural neeg sib tw molecule uas combines kev nyab xeeb thiab ntau - lub hom phiaj zoo rau cov neeg uas muaj kev txhawj xeeb txog kev tswj qhov hnyav, tiv thaiv thiab kev kho mob ntawm daim siab rog, thiab metabolic syndrome.
✅ Antitumor thiab Cell tiv thaiv: Txoj kev sib npaug
Nws yuav tsum tau hais qhia tias tam sim no tag nrho cov tshuaj tiv thaiv -cov qog nqaij hlav yog nyob rau theem ntawm hauv vitro cell lossis tsiaj qauv, thiab tsis muaj cov ntaub ntawv kho mob tib neeg los txhawb nws txoj kev siv los tiv thaiv - tshuaj mob qog noj ntshav. Tab sis nws txoj kev tshawb nrhiav mechanism yog qhov kev tshoov siab heev:
Ligustride nthuav tawm cov teebmeem inhibitory ntawm kev loj hlob, induction ntawm apoptosis, thiab cell voj voog ntes nyob rau hauv ntau yam kab mob qog noj ntshav, xws li mob qog noj ntshav, mob ntsws cancer, thiab mob qog noj ntshav;
Nws txoj haujlwm feem ntau cuam tshuam txog kev tswj hwm Bcl-2 / Bax piv, ua kom cov tsev neeg caspase, thiab inhibiting PI3K / Akt txoj kev;
Nws yog ib qho tsim nyog sau cia tias nws muaj txiaj ntsig zoo hauv kev tiv thaiv cov hlwb ib txwm muaj (xws li myocardial, paj hlwb, thiab lub raum hlwb), uas qhia txog kev txawj ntse ntawm "kev xaiv siab" - qhov no yog qhov tseem ceeb ntawm cov khoom ntuj tsim dua cov tshuaj khomob: thaum tawm tsam cov hlwb txawv txav, lawv kuj tiv thaiv cov haujlwm tseem ceeb ntawm lub cev.
🧬 Extraction thiab purification txoj kev ntawm ligustilide
✅ Txoj kev rho tawm
Txoj kev tshem tawm cov kuab tshuaj: Qhov no yog ib txoj hauv kev siv ntau, feem ntau yog siv cov kuab tshuaj organic xws li ethanol thiab acetone rau kev rho tawm. Piv txwv li, thaum rho tawm Riligustilide los ntawm rhizome ntawm Angelica sinensis, ethanol los yog acetone yog siv los yaj Ligustride los ntawm cov ntaub so ntswg siv cov ntsiab lus ntawm solubility zoo sib xws.
Supercritical fluid extraction method: Supercritical fluid muaj solubility zoo ib yam li kua thiab diffusion muaj peev xwm zoo ib yam li roj. Siv cov pa roj carbon dioxide ua cov kua dej supercritical, rho tawm cov nroj tsuag uas muaj Ligustride ntawm qhov kub thiab txias tshwj xeeb tuaj yeem tshem tawm Ligustride, thiab txoj kev no yog ib puag ncig zoo.
Co distillation method: Piv txwv li, rho tawm ligustilide los ntawm cov roj tsis hloov pauv ntawm Ligusticum chuanxiong tuaj yeem ua tiav siv txoj kev co distillation. Nws muaj cov cuab yeej siv yooj yim, kev ua haujlwm yooj yim, thiab kev nqis peev tsawg, ua rau nws tsim nyog rau kev siv hauv chav kuaj. Txawm li cas los xij, muaj ntau yam uas cuam tshuam rau kev ua tau zoo ntawm cov extraction, xws li qib ntawm cov khoom siv tshuaj crushing, tus nqi ntawm cov dej ntxiv, cov dej ntub dej, lub sijhawm rho tawm, thiab qib cua sov.
✅ Cov txheej txheem purification chromatography technology:
Silica gel kem chromatography: Siv silica gel raws li cov theem nyob ruaj khov thiab cov khoom sib txawv raws li lub sijhawm txawb, kev sib cais thiab kev huv yog ua tiav raws li qhov sib txawv ntawm adsorption thiab desorption peev xwm ntawm Ligustride thiab lwm yam impurities ntawm silica gel. Piv txwv li, thaum sib cais thiab purifying concentrated crude extracts ntawm ib tug silica gel kem, siv roj av ether thiab ethyl acetate rau elution tau zoo cais Ligustride.
Kev kub ceev ntsuas tam sim no chromatography (HSCCC): Tsis siv cov khoom txhawb nqa lossis cov nqa khoom, nws tso siab rau cov kua dej tshwj xeeb dynamic equilibrium tsim los ntawm ob -theem hnyav system nyob rau hauv siab - ceev rotating helical raj rau cais cov qauv raws li sib txawv coefficients. Purification ntawm Ligustride los ntawm Angelica sinensis crude extract siv nws muaj peev xwm ua tau ib tug purity ntawm ntau tshaj 99%.
Silver nitrate hloov kho silica gel kem chromatography: Los ntawm kev siv cov kev sib cuam tshuam tshwj xeeb ntawm cov nyiaj nitrate thiab Ligustride, kev sib cais ua kom zoo dua qub thiab Ligustride hauv Chuanxiong cov roj tseem ceeb tuaj yeem ua kom huv si zoo.
Tswv yim: Hauv kev ua haujlwm, nws yog ib qho tsim nyog yuav tsum xaiv qhov tsim nyog extraction thiab purification txoj kev raws li kev sim tej yam kev mob, raw cov ntaub ntawv, purity yuav tsum, thiab lwm yam. Qee lub sij hawm muaj ntau txoj kev ua ke kom ua tiav cov txiaj ntsig zoo.
🔬 Xaus
Ligustilide yog lub ntuj tsim muaj nyob hauv Suav tshuaj ntsuab xws li Angelica sinensis thiab Ligusticum chuanxiong. Danggui yog "lub hnub qub tshuaj ntsuab" hauv cov tshuaj suav tshuaj, uas tau siv ntau txhiab xyoo. Nws nyiam qhov chaw txias thiab muab faib rau thaj tsam roob ntawm Tuam Tshoj, Nyiv, thiab Kaus Lim Qab Teb. Chuanxiong kuj yog ib qho tshuaj ntsuab uas siv ntau hauv tshuaj, uas muaj cov khoom tseem ceeb ntawm ligustilide.
Hauv cov tshuaj ib txwm siv, Angelica cag feem ntau siv los ua tshuaj ntsuab tshuaj yej. Cov tshuaj yej nws brews muaj zog iab saj, zoo ib yam li saj ntawm fennel. Cov neeg haus cov tshuaj yej no kom tau txais cov as-ham hauv Angelica sinensis, suav nrog ligustilide, txhawm rau ua tiav lub hom phiaj ntawm kev txuag kev noj qab haus huv.
Gaoben lactone muaj keeb kwm ntev ntawm daim ntawv thov hauv cov tshuaj tsoos thiab tau ua haujlwm tseem ceeb rau kev txhim kho cov tshuaj ib txwm siv thiab tib neeg kev noj qab haus huv. Yog tias koj txaus siab rau cov tshuaj ib txwm siv, tej zaum koj yuav xav kawm ntxiv txog qhov xav tsis thoob ntawm cov tshuaj ntuj no.
Xi'an Faithful BioTech Co., Ltd muab koj qhov zoo tshaj plawsligustilideCAS 4431-01-0 nrog purity ntawm 99%, Xa koj cov lus nug kom paub meej ntxiv, Nyem email:sales2@faithfulbio.comTam sim no.
📊Reference
1. Khoom noj khoom haus muaj nuj nqi - Angelica sinensis extract (ligustilide) Zhihu kem [2400-04-10]
2. Ligustride - rau kev tshawb fawb nkaus xwb
3. Txhim kho cov nyhuv ligustilide rau cov nas nrog lub plawv tsis ua haujlwm los ntawm kev tswj hwm PKD1 / ...[2024-01-31]
4. Ligustilide alleviates oxidative kev nyuaj siab thaum lub raum ischemia[2024-08-23]
5. (Z)-Ligustilide|MedChemExpress[2024-07-12]
6. Targeting RXFP1 los ntawm Ligustilide: Ib txoj hauv kev kho tshiab rau cawv ...[2023-12-30]
7. Kev txhim kho cov nyhuv ligustilide rau cov nas uas muaj lub plawv tsis ua haujlwm los ntawm kev tswj hwm PKD1/...[2024-01-06]
8. Ligustilide txhim kho kev paub tsis meej ntawm kev tswj hwm SIRT1[2023-04-21]
9. Kev ua tau zoo thiab kev ua haujlwm ntawm Angelica sinensis [2022-07-04]
10. Z-ligustilide tuaj yeem ua rau qeeb txoj kev mob ntawm NF-B los ntawm inhibiting nws [2012-06-30]