Tetramisole hcl 99% hmoovyog imidazothiazole-raws li kws kho tsiaj anthelmintic raw khoom. Cov khoom tiav yog cov hmoov dawb crystalline hmoov. Nws yog ib tug racemic niam txiv compound ntawm levamisole thiab qhia ib tug yooj yim tshuaj skeleton nrog Levamisole hcl. Nws ua tiav hauv vivo anthelmintic teebmeem los ntawm kev tswj cov cholinesterase thiab cov leeg nqaij tawv nqaij tuag tes tuag taw. Qhov ob yog qhov sib txawv loj hauv chiral configuration, kev ua tau zoo, ntau npaum li cas, thiab raws li daim ntawv thov scenarios. Nws yog dav siv rau kev tswj cov nematodes hauv cov tsiaj nyeg thiab nqaij qaib, thiab rau cov teebmeem anthelmintic hauv cov khoom dej. Nws kuj tseem ua tus qauv rau cholinesterase inhibitors hauv kev sim biochemical.
⚛️ Racemimidazole -thiazole heterocyclic configuration
Tetramisole hcl 99% hmoovmuaj cov mis molecular C₁₁H₁₃ClN₂S thiab molecular hnyav ntawm 240.75. Lub molecule muaj ib tug nruj heterocyclic core tsim los ntawm fusion ntawm imidazole thiab thiazole rings. Ob leeg levorotatory thiab dextrorotatory stereoisomers muaj nyob ntawm cov chaw chiral carbon, uas ua rau tag nrho cov racemic equimolar sib tov. Hydrochloric acid ntsev tsim kev hloov kho optimizes dej solubility ntawm raw khoom. Pharmaceutical-qib 99% hmoov yog tsim los ntawm recrystallization kom tshem tawm cov ntsev inorganic thiab hluavtaws intermediates, kom ntseeg tau tias impurity theem raws li kws kho tsiaj cov khoom raw khoom tswj cov qauv.
Levamisole hcl khaws cia tsuas yog levorotatory chiral monomer nyob rau hauv Tetramisole molecule, tshem tawm cov dextrorotatory configuration tsis muaj anthelmintic kev ua. Cov qauv chiral ib leeg txhim kho lub hom phiaj khi kev ua haujlwm, ua ob npaug ntawm cov khoom xyaw ua haujlwm zoo ntawm tib pawg. Lub physicochemical solubility ntawm hydrochloric acid ntsev tsim yog qhov tseem ceeb zoo ib yam li cov khoom siv raw khoom, thiab cov heterocyclic daim ntawv cog lus ruaj khov yuav zoo ib yam nyob rau hauv acidic thiab alkaline tej yam kev mob.
Ob yam khoom sib koom tib yam pib cov ntaub ntawv thiab cyclization cov tshuaj tiv thaiv txoj hauv kev.Tetramisole hcl 99% hmoovtshem tawm cov kauj ruam daws teeb meem chiral, ua rau cov txheej txheem tsim khoom yooj yim dua thiab txo cov nqi tsim khoom lag luam. Levamisole hcl, ntawm qhov tod tes, yuav tsum tau ntxiv chiral daws teeb meem thiab purification cov kauj ruam, ua rau cov txheej txheem refining complex thiab ho nce tus nqi ntawm cov khoom tiav piv rau racemic precursor.
Ob leeg hydrochloride hmoov yog ruaj khov nyob rau hauv ib txwm kub, lub teeb - pov thawj, thiab kaw cia tej yam kev mob. Lawv nthuav tawm lub nplhaib heterocyclic - qhib hydrolysis nyob rau hauv muaj zog alkaline tej yam kev mob, thiab lawv cov aqueous daws yog acidic. Lawv muaj kev ruaj khov nyob rau hauv feem ntau siv pub premix additives thiab tsis nquag rau physicochemical deterioration.
Hais txog kev ruaj ntseg, Tetramisole hcl hmoov kuj ruaj khov rau lub teeb thiab kub, tab sis cov tshuaj yuav degrade thaum lub sij hawm ntev - cia. Tus neeg muag khoom pom zoo kom khaws cov hmoov ntim ntawm -20℃hauv qab tiv thaiv argon rau 1-2 xyoos. Cov tshuaj yog ruaj khov rau kwv yees li ib hlis ntawm 2-8 degree. Rau kev tswj kom zoo, cov cim tseem ceeb rau cov tshuaj pharmacopoeia-qib cov khoom xyaw tshuaj muaj xws li HPLC, cov khoom muaj feem xyuam, noo noo, hnyav hlau, thiab kho qhov muag.
Tus qauv tsim,Tetramisole hcl 99% hmoovmuaj ntau lub npe, suav nrog (±)-Tetramisole hydrochloride, DL-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride, thiab lwm yam. Nws levorotatory isomer muaj tus lej CAS tus lej 16595-80-5 thiab yog siv ntau dua li tib neeg cov tshuaj immunomodic. Hauv thaj chaw ntawm cov tshuaj kho tsiaj, "Tetramisole" feem ntau yog siv los xa mus rau kev sib xyaw ntawm cov haiv neeg, thaum "Levamisole" yog hais txog ib qho isomer nrog kev ua kom muaj zog.
🎯Kev thaiv cov kab mob cholinergic ua rau cov kab mob parasite.
Tom qab nkag mus rau tus tswv tsev, Tetramisole hcl hmoov xaiv inhibits cholinesterase kev ua haujlwm hauv nematodes, tiv thaiv kev ua haujlwm ntawm hydrolysis thiab tsub zuj zuj ntawm acetylcholine hauv synaptic cleft. Nws tsis tu ncua thiab ntau dhau excites tus kab mob parasite's striated nqaij, inducing luv-lub sij hawm cov leeg nqaij spasms thiab rigidity, ua rau tus cab poob nws lub peev xwm mus rau lub plab hnyuv phab ntsa thiab raug tshem tawm los ntawm peristalsis. Tsuas yog cov levorotatory isomer ntawm lub racemic configuration exerts nws cov nyhuv anthelmintic; cov dextrorotatory feem yuav luag tsis muaj cov tshuaj pharmacological.
Levamisole hcl yog qhov ua tau zoo chiral configuration. Nyob rau tib qhov ntau npaum li cas, nws cov cholinesterase inhibitory muaj peev xwm yog kwv yees li ob zaug ntawm racemic Tetramisole hcl hmoov, nrog rau qhov pib sai dua. Nws tuaj yeem ua tiav tag nrho -spectrum nematode eradication ntawm qis dua. Ob leeg muaj lub hom phiaj zoo ib yam thiab cov txheej txheem anthelmintic; Qhov sib txawv ntawm kev ua tau zoo tsuas yog nyob rau hauv kev faib ua feem ntawm cov khoom siv.
Ob qho khoom siv raw tuaj yeem tswj hwm kev ua haujlwm ntawm lub cev tsis muaj zog lymphocytes hauv cov tsiaj nyeg thiab cov nqaij qaib ntawm cov koob tshuaj tsawg, pab txhim kho tsis yog{0}} tshwj xeeb tiv thaiv. Txawm li cas los xij, vim muaj qhov tsis zoo dextrorotatory isoform, Tetramisole hcl hmoov yuav tsum muaj ntau dua rau kev tiv thaiv kab mob. Levamisole hcl, nrog nws qhov siab -purity chiral kom zoo dua, feem ntau yog siv los ua kev tiv thaiv kab mob hauv cov koob tshuaj me me.
Ob yam tshuaj muaj kev sib raug zoo tsawg heev rau cov tsiaj txhu cholinesterases. Ntawm qhov pom zoo noj, lawv yuav tsis ua rau lub paj hlwb ua haujlwm ntawm cov tsiaj nyeg thiab cov nqaij qaib, nthuav tawm qhov kev nyab xeeb dav dav. Tsuas yog siv ntau dhau lossis ntau npaum li cas yuav ua rau muaj kev ntxhov siab rau lub plab zom mov.
Nyob rau hauv cov nqe lus ntawm immunomodulation, levorotatory isomer ntawm Tetramisole hcl hmoov, Levamisole, nthuav tawm bidirectional immunomodulatory teebmeem ntawm cov tshuaj kho. Nws txhim kho T lymphocyte muaj nuj nqi thiab txhawb nqa macrophage chemotaxis, thiab tau siv los ua kev kho mob rau rheumatoid mob caj dab. Hauv kev tshawb fawb antitumor, Levamisole tau pom tias yuav txhim kho cov nyhuv antiproliferative ntawm 5-fluorouracil, induce qog cell DNA so, cytochrome c tso, thiab caspase-3 activation. Cov nyhuv immunostimulatory no tuaj yeem ua lub luag haujlwm hauv kev kho tshuaj khomob rau kev mob qog noj ntshav.
Ntawm qib neuropharmacological, hauv vivo tsiaj thwmsim tau pom tias kev kho Tetramisole ua rau muaj kev cuam tshuam ntau ntxiv hauv cov nas thiab ua kom lub sijhawm luv luv kom ua tiav cov haujlwm tsis zoo geotropic. Cov nyhuv no qhia tias Tetramisole tuaj yeem koom nrog hauv kev tswj hwm tus cwj pwm coj los ntawm nws cov teebmeem ntawm lub hauv nruab nrab paj hlwb, tab sis cov txheej txheem molecular tshwj xeeb tseem tsis tau paub meej.
🧬 Veterinary deworming thiab biochemical reagents
Tetramisole hcl hmoov feem ntau yog siv los ua raw khoom rau kev lag luam premixed deworming agents hauv cov tsiaj txhu thiab nqaij qaib pub. Nws yog tsuas yog siv rau dav -spectrum nematode tswj nyob rau hauv loj- nplai npua thiab nqaij qaib ua liaj ua teb, leveraging nws cov nqi kom tau txais kev saws mus thoob plaws hauv me me thiab nruab nrab- ua liaj ua teb loj. Nws yog tsis tshua muaj siv nyob rau hauv kev npaj ntawm siab - kawg veterinary tshuaj txhaj tshuaj thiab yog ib txwm muab raws li ib tug hmoov tov rau pub.
Levamisole hcl yog qhov tsim nyog rau kev tsim cov tshuaj siab -kawg txhaj tshuaj thiab cov kua hauv qhov ncauj. Nws tuaj yeem tsim tau rau hauv kev txhaj tshuaj subcutaneous rau kev kho mob ntawm cov kab mob nematode hnyav hauv cov tsiaj me. Nws kuj tseem siv tau rau deworming hauv qee cov tsiaj tshwj xeeb kev lag luam, thiab muaj kev lag luam ntau dua hauv cov tshuaj kws kho tsiaj.
Hauv chaw soj ntsuam biochemical, ob qho tib si siab - cov ntaub ntawv purity purity yuav siv tau los tswj cov tshuaj reagents rau hauv vitro cholinesterase inhibition kev soj ntsuam. Tetramisole hcl hmoov feem ntau yog siv rau kev ntsuam xyuas ntxhib, thaum Levamisole hcl calibration - cov khoom qib yog siv los ua cov khoom siv hauv teb chaws tus qauv ntsuas cov ntaub ntawv siv rau kev txiav txim siab ntawm cov enzyme tsis ua haujlwm.
Hauv kev lag luam aquaculture, Tetramisole hcl hmoov yog siv dav hauv kev pub noj los tswj cov hnyuv nematodes hauv cov ntses. Nws nyob qhov qis-kawg deworming raw khoom lag luam hauv aquaculture vim nws cov nqi- ua tau zoo. Levamisole feem ntau yog siv rau kev tiv thaiv kab mob ua kom zoo thiab tswj hwm cov khoom lag luam muaj txiaj ntsig siab -.
Hauv kev tshawb fawb biochemical reagents, Tetramisole hcl hmoov yog "tus qauv kub" cov cuab yeej rau alkaline phosphatase (ALP) inhibition. Hauv kev tshawb nrhiav cov tswv yim xws li immunohistochemistry, nyob rau hauv situ hybridization, thiab Western blotting, cov kev ua ntawm endogenous ALP generates ib tug siab keeb kwm yav dhau teeb liab, cuam tshuam nrog rau qhov tshwj xeeb nrhiav tau ntawm lub hom phiaj molecules. Ntxiv Tetramisole (feem ntau ntawm kev ua haujlwm siab ntawm 0.5-2 mM) rau cov tshuaj tiv thaiv tuaj yeem cuam tshuam qhov cuam tshuam los ntawm endogenous ALP.
Hauv kev txhim kho tshuaj thiab tshuaj xyuas, Tetramisole ua haujlwm raws li kev sojntsuam tshuaj los kawm txog lub luag haujlwm ntawm ALP hauv cov pob txha metabolism, o, thiab qog nqaij hlav. Vim nws muaj zog inhibition ntawm pob txha- hom ALP, nws nquag siv nyob rau hauv vitro mechanism kev tshawb fawb ntawm osteoporosis thiab osteosarcoma. Hauv cov txheej txheem biology, sib piv cov qauv- kev sib raug zoo ntawm Tetramisole hcl hmoov thiab nws cov derivatives tuaj yeem nthuav tawm hom kev khi ntawm ALP inhibitors rau lub enzyme lub chaw ua haujlwm, muab cov qauv qauv rau kev tsim cov kev xaiv ALP inhibitors.
🔭 Txheej txheem optimization thiab daim ntawv thov nthuav dav
Green synthesis txheej txheem rauTetramisole hcl 99% hmoovtxuas ntxiv mus, ua haujlwm qis -kub catalytic cyclization los txo cov khoom tsim tawm, tswj kom ruaj khov 99% purity nyob rau hauv cov khoom tiav, ntxiv txo cov nqi tsim khoom ntau, thiab ua kom nws txoj hauj lwm zoo li tus nqi anthelmintic.
Txoj kev daws teeb meem tshiab chiral siv hauv -situ hloov dua siab tshiab ntawm racemic Tetramisole los npaj Levamisole hcl, ua kom yooj yim daws qhov poob thiab ua tiav cov phiaj xwm sib cais ntawm ib qho -helical daim ntawv los ntawm racemic API, yog li ua tiav tag nrho cov saw hlau.
Sustained -tso tawm txheej txheej txheej txheem kev txhim kho yog nce ib txhij rau ob yam khoom. Cov hmoov txheej hloov kho kom tsis txhob muaj cov tshuaj degradation ntxov ntxov los ntawm gastric acid, ua kom lub plab hnyuv tawm mus ntev thiab txo qhov zaus ntawm ib zaug - noj tshuaj. Tetramisole-coated cov khoom lag luam lub hom phiaj kev lag luam ruaj khov- tso cov tshuaj kho tsiaj, thaum levamisole-coated khoom lub hom phiaj siab- kawg tsiaj txhu thiab nqaij qaib noj.
Combined anthelmintic formulations yog txuas ntxiv txhim kho.Tetramisole hcl 99% hmoovua ke nrog albendazole tsim ib qho dav -spectrum compound hmoov, hais ob leeg nematodes thiab tapeworms. Levamisole thiab ivermectin tau sib xyaw ua ke los tsim cov txheej txheem siab - kawg.
Hauv thaj chaw tshuaj tua kab, qis- concentration Tetramisole tab tom tshawb nrhiav raws li cov av nematode inhibitor. Agricultural kab repellent adjuvants yog tsim raws li tus nqi qis. Txawm li cas los xij, vim muaj kev txwv tus nqi, levamisole tsis tshua tau txuas mus rau thaj chaw ua liaj ua teb.
Hais txog cov khoom siv tshuaj nquag (API) cov khoom, siab -purity Tetramisole hcl hmoov feem ntau yog siv los ua kom tau raws li qhov yuav tsum tau ua ntawm cov tshuaj kws kho tsiaj thiab cov tshuaj reagents. Nws cov txheej txheem synthesis suav nrog kev tsim kho ntawm imidazole thiab thiazole rings thiab kev daws teeb meem ntawm racemic mixs. Vim Tetramisole yog ib qho anthelmintic, nws cov tshuaj kws kho tsiaj feem ntau xav tau kev tswj cov tshuaj muaj feem xyuam thiab cov hlau hnyav. Hauv toxicology, Tetramisole hcl hmoov yog cais raws li Class 3 mob toxicity tshuaj, cais nws raws li ib tug txaus ntshai khoom. Hauv tib neeg thiab tsiaj txhu, kev raug mob ntau dhau tuaj yeem ua rau xeev siab, ntuav, mob taub hau, leukopenia, thiab txawm tias agranulocytosis. Hais txog kev ua yeeb tshuaj tsis raug cai, cov ntaub ntawv ntawm levamisole hydrochloride deev nrog cov yeeb yaj kiab, ua rau muaj mob loj heev neutropenia thiab vasculitis cutaneous, tau txais kev saib xyuas tseem ceeb los ntawm forensic toxicology.
Hauv kev tswj kom zoo, kev txiav txim siab ntawm Tetramisole hcl hmoov cov ntsiab lus, enantiomeric purity, thiab kev ruaj ntseg yog cov ntsiab lus tseem ceeb ntawm cov tuam txhab API. Cov ntim me me rau kev tshawb fawb lub hom phiaj sib txawv ntawm cov ntim loj hauv kev tsim tshuaj kho tsiaj raws li qhov loj me, crystallinity, thiab impurity profiles; Cov kws tshawb fawb yuav tsum xaiv cov kev qhia tshwj xeeb uas tsim nyog raws li lawv qhov kev siv.
Xaus
Tetramisole hcl hmoov yog lub luag haujlwm molecule uas txuas qhov sib txawv ntawm "pasture deworming" thiab "laboratory enzyme inhibition." Nyob rau hauv cov kws kho tsiaj, nws yog ib tug classic dewormer rau kev tswj cov hnyuv nematodes; Hauv kev tshawb fawb txog kev ua neej nyob, nws yog ib qho cuab yeej tsim nyog rau kev tshem tawm keeb kwm cuam tshuam los ntawm alkaline phosphatase. Nws cov levorotatory isoform, Levamisole, tau nthuav dav nws cov ntawv thov kom suav nrog kev siv tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob ntxiv. Raws li qib siab -purity active tshuaj muaj, Tetramisole tswj kev lag luam ruaj khov nyob rau hauv cov khoom siv kuaj mob thiab cov tshuaj molecular biology reagents vim nws cov kev xaiv heev inhibition ntawm ALP.
Raws li ib tug ua tus neeg muag khoom ntawmTetramisole hcl 99% hmoov, peb nkag siab txog qhov tseem ceeb ntawm cov saw hlau ruaj khov hauv kev sib tw ua lag luam. Peb cov txheej txheem kev tsim khoom thiab cov khoom lag luam tswj xyuas kom cov khoom siv tas mus li txawm tias cov khoom muag sib txawv. Thov saib peb cov khoom lag luam nthuav dav thiab sib tham txog koj qhov kev xav tau nrog peb cov kws tshaj lij ntawmallen@faithfulbio.com.
Cov ntaub ntawv
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