Idra-21 yog ib qho organic compound tsim nyob rau hauv 1990s. Raws li txoj cai, nws yog derivative ntawm benzothiadiazole. Nws cov molecules muaj nyob rau hauv daim ntawv ntawm ob optical isomers. Lawv qhov txawv tsis yog tsuas yog nyob rau hauv lawv lub peev xwm los cuam tshuam lub teeb polarized tab sis kuj nyob rau hauv lawv cov tshuaj pharmacological. Tsuas yog (ntxiv rau) - Idra-21 enantiomers tau pom los qhia txog kev ua haujlwm lom neeg.
IDRA-21 belongs rau ib pawg ntawm nootropic compounds. Nws ua raws li kev hloov pauv ntawm AMPA glutaminergic receptor, ua tsaug rau qhov nws txhawb kev txawj ntse xws li kev nco, kev txhawb siab los ua, lossis kev xav.
IDRA-21 yog ib qho khoom sib xyaw uas tau txais los ntawm kev kuaj sim.
IDRA-21 ua haujlwm li cas?
Cov teebmeem ntawm neurotransmission.
IDRA-21 ua raws li qhov zoo allosteric AMPA receptor modulator. Los ntawm kev txuas mus rau nws sab nraud ntawm qhov chaw ntawm kev khi ntawm thawj ligand, nws yuav pab kom nws cov kev ua si, ntxiv dag zog rau cov nyhuv ntawm stimulating lub receptor thiab tiv thaiv nws desensitization. Nyob rau hauv lub hauv paus paj hlwb, glutamate ua raws li lub ntsiab stimulant neurotransmitter. Nws yog ib qho tseem ceeb rau cov chav kawm tsim nyog ntawm ntau cov txheej txheem kev txawj ntse, suav nrog kev kawm thiab kev sib xyaw ntawm cov ntaub ntawv tshiab.
Kev paub txog teebmeem.
The results of numerous studies confirmed the effectiveness of IDRA-21 as a factor in improving cognitive abilities. Tests conducted in rats showed that their oral intake significantly improved the performance of animals in passive avoidance and water labyrinth tests, which was not observed with placebo. In the same experiment, cognitive capacity was reduced in rats by administering alprazolam (a compound from the benzodiazepines group – positive allosteric GABA-A receptor modulators) and scopolamine (a competitive acetylcholine muscarine receptor antagonist). IDRA-21 has also been shown to be 20-30 times stronger than aniracetam.
Cov txiaj ntsig zoo sib xws tau txais los ntawm kev xa cov nas mus rau qhov kev kuaj pom cov khoom, uas ntsuas qhov ua tau zoo ntawm lub cim xeeb episodic hauv nas raws li lawv cov lus teb rau cov khoom paub thiab cov khoom tshiab 24 teev tom qab pom thawj zaug. Kev tswj hwm ntawm IDRA-21 ib teev ua ntej txhua qhov kev sim sib tham tau txhim kho kev paub txog cov khoom uas tau pom yav dhau los, thiab cov txiaj ntsig zoo tshaj plaws tau txais thaum nas coj cov tshuaj no ob qho tib si ua ntej kev nthuav qhia thiab ua ntej sim ua kom paub txog cov khoom. Tsis muaj kev zam txim rau kev rov ua haujlwm ntawm IDRA-21 tau raug pom.
IDRA-21 kuj tau pom tias muaj txiaj ntsig zoo rau kev ua haujlwm ntawm lub hauv paus paj hlwb hauv primates. Hauv ib qho kev sim, ob ore patas liab tau muab alprazolam, uas ua rau kev kawm tsis zoo. Txawm li cas los xij, cov nyhuv no raug tshem tawm thaum cov liab tau txais aniracetam (30 mg / kg lub cev qhov hnyav) lossis IDRA-21 (3 thiab 5.6 mg / kg lub cev qhov hnyav) ib teev ua ntej no benzodiazepine.
Hauv lwm qhov kev sim, nrog kev koom tes ntawm kev xav tau los ntawm 7 mus rau 27 xyoo, liab tau qhia kom nias lub pob sib xws rau cov xim ntawm cov duab nthuav tawm. Lub sijhawm ntawm kev saib thiab nias lub pob yog qhov ntsuas ntawm kev txawj ntse. Hauv cov tsiaj hluas (nruab nrab hnub nyoog li ntawm 10 xyoo), IDRA-21 ntawm ib koob ntawm 0.15-10 mg/kg lub cev qhov hnyav ua rau muaj kev txo qis hauv lub sijhawm no piv rau cov placebo. Cov nyhuv no kav ntev txog 48 teev. Hauv cov pab pawg ntawm cov laus laus (tshaj li 20 xyoo) uas nws lub khawm qeeb siab dua li cov neeg hluas, IDRA-21 kuj tau ua pov thawj zoo, txawm tias cov teebmeem me me.
The effects of IDRA-21 were also compared with huperzine A, an acetylquinesterase inhibitor (an enzyme that inactivates acetylcholine). For this purpose, several objects were presented to macaques, which were then covered for a period of 10–90 seconds. Then the items were presented again, but they were accompanied by a new one. The task of the monkeys was to point him out, for which they were rewarded with a portion of food. Administration of huperzine A helped to improve the results of those individuals who did less well with the test, but not those who achieved the best results – in this case, the opposite effect was observed. In contrast, IDRA-21 significantly improved performance, especially in animals whose initial results were worse.
Qhov cuam tshuam rau lub sijhawm ntev - kev txhim kho synaptic
The results of scientific analyses confirmed that IDRA-21 contributes to the stimulation of long-term synaptic enhancement (LTP) within hippocampal neurons. This phenomenon is the basis of neuroplasticity – the formation of new connections between nerve cells as a result of their multiple simultaneous stimulations. Therefore, it is crucial for the process of acquiring information and acquiring new skills.
Txoj kev xav
Cov txiaj ntsig ntawm ntau cov kev tshawb fawb tshawb fawb pom tau tias cov tshuaj pab txhawb kev ua haujlwm ntawm AMPA receptors muaj cov tshuaj tiv thaiv kev ntxhov siab. Kev sim nrog nas pom tias lawv muaj peev xwm zoo sib xws rau tricyclic antidepressant imipramine. Qhov no tau lees paub los ntawm qhov tseeb tias kev siv AMPA receptor antagonists tshem tawm cov txiaj ntsig tau txais los ntawm kev tswj hwm nws qhov zoo allosteric modulators, tej zaum vim muaj peev xwm ntawm cov tebchaw no los txhawb kev tsim cov hlwb - tau txais txiaj ntsig neurotrophic (BDNF) , nws qib feem ntau qis dua thaum muaj kev nyuaj siab.
Yuav siv IDRA-21 li cas?
Kev noj tshuaj
Thaum noj tshuaj ntxiv, koob tshuaj ntawm 5 mus rau 25 mg ib hnub feem ntau yog siv. Nws yog qhov zoo tshaj plaws los siv IDRA-21 yam tsis muaj zaub mov, thaum sawv ntxov. Vim qhov tseeb tias cov teebmeem tshwm sim mus txog 48 teev, qhov sib xyaw no zoo haum rau qee lub sijhawm ntxiv, tsis ntau tshaj 3-4 zaug hauv ib lub lis piam.
Ua ke
Txhawm rau txhawm rau txhawb kev nco, kev xav, thiab kev muaj peev xwm kawm ntxiv, IDRA-21 tuaj yeem ua ke nrog:
Huperzin A (Huperzia serrata)
Forskolin (Coleus forskohlii)
choline (choline divalent, alpha{0}}GPC, CDP-choline)
oxyracetam
Txhawm rau kom muaj txiaj ntsig zoo ntawm IDRA-21 ntawm kev xav, nws tuaj yeem ua ke nrog:
NSI-189
tshuaj aniracetam
taurine
Brahmi (Bacopa monnieri)
Kev cuam tshuam tsis zoo thiab kev phiv
Kev noj ntau dhau ntawm IDRA-21 tuaj yeem ua rau khaus lossis nyuaj rau pw tsaug zog.
IDRA-21 yuav tsum tsis txhob siv rau cov tib neeg tom qab mob stroke lossis nrog rau lwm yam mob tom qab lub paj hlwb ischemia, vim cov paj hlwb puas tuaj yeem ua rau tsis zoo.