Ticagrelor yog nyob rau hauv ib chav kawm ntawm cov tshuaj hu ua antiplatelet tshuaj. Nws ua haujlwm los ntawm kev tiv thaiv platelets (ib hom ntshav cell) los ntawm kev sau thiab tsim cov hlab ntsha uas tuaj yeem ua rau lub plawv nres lossis mob stroke.
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Cov khoom txuas
https://www.faithful-chemical.com/api-powder/ticagrelor-powder-cas-274693-27-5.html
Ticagrelor, ib tug tshiab antiplatelet agglutination tus neeg sawv cev, yog lub ntiaj teb thawj reversible binding P2Y12 adenosine diphosphate receptor antagonist, uas thim rov qab ua rau purinoceptor2 (P2) subtype P2Y12 ntawm vascular du leeg hlwb (VSMC) tsis muaj metabolic activation. Nws muaj cov nyhuv inhibitory ntawm platelet aggregation tshwm sim los ntawm adenosine diphosphate (ADP), thiab cov nyhuv sai sai tom qab siv, thiab tuaj yeem txhim kho cov tsos mob ntawm cov neeg mob plawv mob plawv. Tsis zoo li thienopyridines, ticagrelor yog ib qho kev thim rov qab ntawm P2Y12 receptor, ua rau nws muaj txiaj ntsig tshwj xeeb rau cov neeg mob uas xav tau kev kho mob anticoagulant ua ntej tom qab phais.
Kev tshuaj ntsuam xyuas
Ticagrelor qhov kev pom zoo los ntawm US Food and Drug Administration (FDA) yog ua raws li cov txiaj ntsig ntawm PLATO kev tshawb fawb soj ntsuam, uas kuj tau luam tawm nyob rau hauv lub koob npe nrov TheLancet Lancet hauv 2010. PLATO yog ib qho randomized, ob-dig muag, ntau qhov kev kawm ntawm {{2 }} cov chaw hauv 43 lub teb chaws, nrog rau tag nrho ntawm 18,624 tus neeg mob tau pw hauv tsev kho mob rau cov tsos mob ntawm tus mob coronary. Txhua tus neeg mob tau muab tshuaj aspirin ua ke nrog ticagrelor lossis tshuaj aspirin ua ke nrog clopidogrel. Piv nrog clopidogrel, cov neeg mob uas noj ticagrelor muaj 16 feem pua txo qis dua ntawm kev mob plawv, mob stroke lossis tuag. Qhov kev sim PLATO tau qhia txog qhov txiaj ntsig ntawm Ticagrelor hauv kev txhim kho tus neeg mob txoj sia nyob thiab tam sim no tau pom zoo los ua ib qho kev kho mob rau cov mob plawv. Tsis tas li ntawd, nws txo qis kev phais mob ntsig txog myocardial infarction thiab post-stenting thrombosis yam tsis muaj kev pheej hmoo ntawm kev tuag los ntshav thiab lwm yam teeb meem loj. Txawm hais tias Ticagrelor tau pom qhov zoo dua Clopidogrel hauv PLATO kev tshawb fawb soj ntsuam, nws kuj muaj ob qhov tsis zoo: ib qho yuav tsum tau siv ob zaug ib hnub es tsis txhob siv ib hnub ib zaug li Clopidogrel; Qhov thib ob, nws tuaj yeem ua rau muaj kev phiv xws li ua pa nyuaj, ntau dua li clopidogrel. Nws muaj ib nrab ntawm lub neej tsuas yog 12 teev thiab yuav tsum tau ua ob zaug hauv ib hnub, uas yog qhov nyuaj rau cov neeg mob uas tsis ua raws cai. Tom qab tag nrho, tsis yog txhua tus neeg mob muaj peev xwm ua tau raws li hom tshuaj no. Hauv kev xyaum, nws kuj tau pom tias kwv yees li 20% ntawm cov neeg mob kho nrog clopidogrel tsis ua raws li tus kws kho mob cov lus qhia, thiab cov neeg mob no tsis tshua ua raws li cov tshuaj noj thaum siv ticagrelor. Yog li ntawd, rau cov tshuaj uas tuaj yeem thim rov qab sai sai, txwv tsis pub cov tshuaj yuav ua rau tus neeg mob muaj feem yuav mob thrombosis, ua rau lub plawv nres lossis mob stroke.
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Pharmacodynamic yam ntxwv
Ticagrelor, tus tswv cuab ntawm cov tshuaj cais tawm cyclopentyltriazacil (CPTP), yog ib qho kev xaiv adenosine diphosphate (ADP) receptor antagonist uas ua rau P2Y12ADP receptor los inhibit ADP-mediated platelet activation thiab aggregation, zoo ib yam li cov txheej txheem ntawm kev ua ntawm thienopyridine tshuaj xws li Clopidogrel. Tab sis qhov txawv yog tias kev sib cuam tshuam ntawm ticagrelor thiab platelet P2Y12 ADP receptor yog thim rov qab, tsis muaj kev hloov pauv thiab teeb liab, thiab platelet muaj nuj nqi hauv cov ntshav tau rov qab sai sai tom qab tshem tawm.
Puas yog ticagrelor zoo dua li tshuaj aspirin?
Ticagrelor yog me ntsis zoo dua li clopidogrel thiab tshuaj aspirin hauv kev tiv thaiv kev mob stroke, tshwj xeeb tshaj yog mob hlab ntsha tawg, nrog rau kev nyab xeeb tseem ceeb. Rau cov neeg mob uas muaj keeb kwm ntawm AIS / TIA, kev siv ticagrelor yog qhov zoo tshaj rau kev siv clopidogrel lossis tshuaj aspirin hauv kev txo qis kev pheej hmoo ntawm mob stroke tom ntej.
Vim li cas ticagrelor tsis siv?
Los ntshav txaus ntshai
Ticagrelor, zoo li lwm yam tshuaj antiplatelet, tuaj yeem ua rau muaj teeb meem loj, qee zaum tuag taus, los ntshav. Ticagrelor yuav tsum tsis txhob siv nyob rau hauv cov neeg mob uas muaj cov kab mob pathological los ntshav lossis keeb kwm ntawm intracranial hemorrhage.
Thaum twg yog ticagrelor contraindicated?
BRILINTA yog contraindicated nyob rau hauv cov neeg mob uas muaj keeb kwm ntawm intracranial hemorrhage (ICH) vim muaj kev pheej hmoo siab ntawm rov tshwm sim ntawm ICH nyob rau hauv cov neeg no. BRILINTA yog contraindicated nyob rau hauv cov neeg mob uas muaj active pathological los ntshav, xws li peptic ulcer los yog ICH.
A: Peb muaj warehouses nyob teb chaws Europe, America thiab Australia. Nyob rau tib lub sijhawm, yog tias koj tuaj ntawm Tebchaws Europe, cov khoom tuaj yeem raug xa los ntawm lub teb chaws Yelemees, thiab yog tias koj tuaj ntawm Asmeskas lossis Canada, cov khoom tuaj yeem xa los ntawm California.
A: Peb feem ntau xa cov khoom nrog cov khoom pov tseg sab nraud thiab ob txheej txheej sterile pob tshab hauv lub hnab.Peb tau sim ntau txhiab txoj hauv kev, nws zoo li hnyav thiab tsis pom kev.
A: Feem ntau qhov kev txiav txim yuav xa tuaj tsis pub dhau 3-7 hnub tom qab qhov kev txiav txim tau lees paub, tshwj tsis yog cov khoom lag luam customized.
A: Thov cia kuv paub cov khoom koj tab tom nrhiav, kom muaj nuj nqis thiab lub teb chaws qhov chaw uas pab kuv muab tus nqi tsim nyog; Tom qab koj lees paub tag nrho cov ntsiab lus ntawm kev txiav txim, them nyiaj ua ntej thiab muab qhov chaw nyob Shipping rau peb.Peb npaj cov khoom xa tuaj. thawj zaug tom qab tau txais kev them nyiaj thiab muab kev pab cuam tom qab muag tom qab koj tau txais parcel.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com