Thymalfasin hmoovyog ib tug hluavtaws version ntawm Thymosin Alpha-1, uas yog ib txwm tshwm sim peptide Ameslikas cais tawm ntawm thymus. Qhov kev tiv thaiv kab mob no tau nyiam ntau yam vim nws muaj peev xwm siv hauv kev kho mob ntawm ntau yam kab mob. Nws feem ntau ua rau lub cev tiv thaiv kab mob, txhim kho lub cev tiv thaiv lub peev xwm. Cov koom haum tshawb fawb thoob plaws ntiaj teb tau kawm txog thymosin peptides los tshawb txog lawv lub peev xwm hauv kev kho mob ntev, mob qog noj ntshav, thiab kab mob autoimmune. Thymosin peptide hmoov yog cais raws li immunomodulatory peptide thiab tau dhau los ua ntau yam kev sim tshuaj, qee qhov tau pom cov txiaj ntsig txhawb nqa, tshwj xeeb tshaj yog hauv kev kho kab mob siab B thiab C, nrog rau qee yam mob qog noj ntshav.
Yuav ua li cas yog lub mechanism ntawm kev txiav txim thiab pharmacological zog ntawmThymalfasin?
Lub luag haujlwm tseem ceeb ntawm Thymosin Alpha-1 hmoov yog los txhawb kev sib txawv thiab kev loj hlob ntawm T lymphocytes. Nws tuaj yeem hloov cov qia hlwb uas tsim los ntawm cov pob txha pob txha mus rau hauv T lymphocytes, txhim kho kev tiv thaiv kab mob hauv lub cev, tab sis muaj kev cuam tshuam me ntsis ntawm kev tiv thaiv kab mob. Cov kev sim tsiaj tau pom tias thymosin 1 tuaj yeem ua ib feem lossis yuav luag tag nrho cov kev tiv thaiv kev tiv thaiv kab mob thiab kev cog qoob loo- tawm tsam tus tswv teb hauv thymus deprived nas, revive atrophied lymphoid cov ntaub so ntswg, txhawb lymphocyte proliferation, mature lymphocytes, thiab hloov lawv mus rau hauv lub cev tsis muaj zog lymphocytes.
Cov txheej txheem ntawm kev ua ntawm Thymosin a1 peptide feem ntau suav nrog peb yam: ① nws tuaj yeem cuam tshuam ntau theem ntawm T cell sib txawv thiab kev loj hlob; ② Muaj kev ua haujlwm ntawm kev tswj kev tiv thaiv kab mob ntawm lub cev; ③ tuaj yeem txhim kho cov lus teb ntawm cov laus T hlwb rau antigens lossis lwm yam stimuli.Thymalfasintsis muaj hom tshwj xeeb tshwj xeeb, uas muab kev yooj yim rau nws daim ntawv thov kho mob.
Dab tsi yog qhov txawv ntawm Thymosin Alpha-1 hmoov thiab lwm yam tshuaj immunomodulatory xws li interferon thiab interleukin?
Thymalfasin hmoov, interferon, thiab interleukin -2 txhua tus muaj lawv qhov chaw kho mob. Lub caj pas thymus plays lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev tiv thaiv kab mob vim nws qhov mob me me thiab tsis tu ncua, kev tswj ob txoj kev, thiab kev nyab xeeb siab. Nws yog qhov tsim nyog tshwj xeeb rau cov neeg mob uas xav tau kev kho mob ntev - thiab muaj cov kab mob tsis zoo. Interferon yog irreplaceable nyob rau hauv kev kho mob ntawm tus kab mob siab kab mob siab thiab hematological malignancies vim nws muaj zog antiviral thiab anti-mob nyhuv. Interleukin-2 ua lub luag haujlwm tshwj xeeb hauv kev kho cov qog nqaij hlav zoo heev vim nws lub zog tiv thaiv kab mob ua kom muaj zog. Kev xaiv kho mob yuav tsum ua raws li tus neeg mob qhov tshwj xeeb, kev tiv thaiv kab mob, kev ua siab ntev, thiab cov hom phiaj kho mob kom ua tiav kev kho tus kheej thiab meej.
Thymosin Alpha-1 hmoov muaj kev phiv dab tsi?
Zoo li lwm yam khoom siv tshuaj,Thymosin Alpha-1 hmoovkuj muaj kev phiv. Cov kev mob tshwm sim feem ntau suav nrog qhov chaw txhaj tshuaj, xws li liab, o thiab mob. Cov tshuaj tiv thaiv no feem ntau yog me me thiab ib ntus. Cov kev mob tshwm sim hauv lub cev tsis tshua muaj, tab sis kuj muaj xws li mob khaub thuas-zoo li cov tsos mob xws li kub taub hau, qaug zog thiab mob nqaij. Qee qhov xwm txheej, cov neeg mob tau qhia txog qhov tsis xis nyob hauv plab, xws li xeev siab thiab raws plab. Nws yog ib qho tsim nyog sau cia tias txawm hais tias Thymalfasin feem ntau zam tau zoo, nws yog txwv tsis pub rau cov neeg uas tsis haum rau ib qho ntawm nws cov khoom. Tsis tas li ntawd, cov neeg mob uas muaj kab mob autoimmune yuav tsum tau siv nrog ceev faj, vim tias kev ua kom lub cev tsis muaj zog tuaj yeem ua rau tus mob hnyav dua. Vim tsis muaj cov ntaub ntawv kev nyab xeeb txaus rau cov poj niam cev xeeb tub thiab cov poj niam cev xeeb tub, cov poj niam cev xeeb tub thiab cov poj niam cev xeeb tub yuav tsum tsis txhob siv.Thymalfasin hmoovtshwj tsis yog cov kws kho mob xav tias nws tsim nyog kiag li.
Yuav ua li cas thiaj tsim tau siab -Thymalfasin hmoov zoo?
Thymosin Alpha-1 API hmoovyog ib qho protein thiab peptide hormone nrog lub cev tiv thaiv kab mob uas tsim los ntawm thymic superficial cortex thiab medulla epithelial hlwb. Nws yog ib qho acidic peptide tsim los ntawm 28 amino acids thiab yog cov tshuaj lom neeg ua haujlwm nrog ntau yam kev ua haujlwm lom neeg. Txawm li cas los xij, vim muaj kev txwv thev naus laus zis, nws cov khoom tsim tau dhau los ntawm kev sib tw thiab tig.
1. Biochemical extraction method: Thymic peptide npaj (ib qho sib xyaw ntawm ntau yam peptides) feem ntau tau los ntawm cov ntaub so ntswg tsiaj, yog li lawv cov dej num sib txawv heev. Vim lawv qhov muaj nyob hauv cov tsiaj proteins, kuj tseem muaj peev xwm ua xua. Lub thymus muab rho tawm los ntawm biochemical txoj kev siv tib neeg embryonic thymus raws li raw khoom muaj ib tug tsawg tawm los tab sis zoo kho nyhuv. Xav txog qhov txwv tsis pub muaj cov khoom siv raw, tus nqi siab, tsis tshua muaj txiaj ntsig, thiab cov txheej txheem rho tawm nyuaj, muaj ntau yam teeb meem hauv kev tsim khoom loj -, thiab qhov kev cia siab ntawm kev loj hlob tsis zoo.
2. Txoj kev ua lag luam thymus tau tsim los siv txoj kev SPSS, thiab kev sib xyaw ua ke thiab kev ua kom huv yog ua los ntawm cov txheej txheem tsim nyog. Siv cov resin ua tus cab kuj thiab Fmoc rau cov khoom sib txuas-theem synthesis, 28 amino acids tau ua ke ua ke thiab ua ke raws li txoj kev thymus. Lub N-terminal amino acids tau acetylated nrog acetic anhydride thiab raug kev tawg siv TFA ua lub ntsiab cracking reagent kom tau cov khoom nyoos. Cov khoom nyoos tau npaj thiab sib cais los ntawm HPLC kom tau txais txoj kev thymus tshiab cov khoom ntshiab, uas tau ua kom huv ntxiv kom tau txais cov khoom siv thymus tshiab.
3. Muaj peb hom kab mob genetic engineered uas tau los ntawm genetic engineering txoj kev: (1) cloning multi stranded genes rau hauv lub party kom tau cov hom phiaj kab mob, uas yog thaum kawg qhia nyob rau hauv daim ntawv ntawm inclusion lub cev. Muaj cov ntawv ceeb toom tias muaj ntau cov noob caj noob ces siv txoj kev thymus tau tsim los siv cov txheej txheem random annealing thiab PCR, thiab cloned rau hauv Escherichia coli. (2) Lub synthesized fusion protein noob yog recombined rau hauv ib tug vector thiab hloov mus ua ib tug tswv tsev los tsim ib tug genetic engineered kab mob. Piv txwv li, raws li lub teeb liab peptide noob hauv plasmid, ib qho kev qhia plasmid tau tsim thiab hloov mus rau hauv Pichia pastoris los ntawm electroporation. Tom qab ntawd, fusion protein tau raug ntxias kom nthuav tawm nrog methanol thiab raug rau enzyme zom thiab lwm yam kev kho mob kom tau txais txoj kev thymic. (3) Ua ntej, ib qho kev qhia vector tau tsim thiab xa mus rau tus tswv tsev kom dhau los ua cov kab mob genetic engineered, tom qab ntawd los ntawm fermentation thiab cog qoob loo kom tau txais cov khoom lag luam. Txuas cov synthesized thymic txoj kev monomer noob rau cov plasmid sib xws, tsim ib qho kev qhia vector, thiab tom qab ntawd muab tso rau hauv Pichia pastoris. Cov khoom lag luam lub hom phiaj yog tso ncaj qha rau hauv fermentation broth, thiab tom qab ntawd ua kom huv hauv ob kauj ruam kom tau txais qib siab - purity thymic txoj kev nrog ob peb kauj ruam sib cais, tus nqi qis, thiab kev tsim khoom yooj yim.
Peb lub tuam txhab yog nquag tsim cov txheej txheem kev tsim cov noob caj noob ces. Raws li cov txiaj ntsig kev xeem tam sim no, cov khoom tau txais muaj qhov zoo dua qub, tsis muaj impurities tsawg dua, thiab tus nqi ntau dua - txoj kev siv tau zoo. Yog tias koj txaus siab, thov sau ntawv rau kuv ntawm email.sales6@faithfulbio.com
Yuav ua li cas kom tau txais kev tshawb fawb thiab kev loj hlob tshiab ntawm Thymalfasin?
Thymalfasintau pom muaj peev xwm kho tau zoo hauv thaj tsam ntawm immunotherapy. Nws tuaj yeem txhim kho ntau yam ntawm lub cev tiv thaiv kab mob, ua rau nws yog ib qho tshuaj zoo tshaj plaws rau kev kho mob ntev, qee yam qog noj ntshav, thiab cov kab mob autoimmune. Txawm hais tias Thymosin Alpha 1 feem ntau zam tau zoo, nws cov kev mob tshwm sim thiab kev cuam tshuam cov tshuaj muaj peev xwm tseem yuav tsum tau ua tib zoo soj ntsuam xyuas kom muaj kev nyab xeeb thiab siv tau zoo. Nrog kev tshawb nrhiav txuas ntxiv mus,thymosin alpha-1 peptide hmoovcia siab tias yuav dhau los ua lub hauv paus ntawm kev kho cov kab mob tiv thaiv kab mob. Yog tias koj muaj kev tshawb fawb hauv cheeb tsam no, thov hu rauXi'an Faithful BioTech Co., Ltd
Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, Thov hu rau peb ntawmEmail: sales6@faithfulbio.com; Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.