Hengrui Pharmaceuticals tshaj tawm rau lub Tsib Hlis 25th tias tsis ntev los no, lub tuam txhab tau txais "Daim Ntawv Ceeb Toom Txog Kev Siv Tshuaj Ntxiv" pom zoo thiab muab los ntawm National Drug Administration, thiab lub tuam txhab Mesna Txhaj Tshuaj tau dhau qhov kev soj ntsuam zoo thiab kev ua tau zoo ntawm cov tshuaj generic. Ua tus thawj domestically tsim thiab soj ntsuam cov khoom ntawm no ntau yam. Txog tam sim no, Hengrui Pharmaceutical tau nqis peev 5.17 lab yuan hauv kev tshawb fawb thiab kev tsim kho cov nuj nqis rau kev ntsuas qhov sib xws ntawm cov khoom no.
Cov tshuaj thawj yog tsim los ntawm Asta Medica AG thiab tau pom zoo muag hauv lub teb chaws Yelemees thaum lub Kaum Ob Hlis 1979. Nws tau pom zoo rau kev nkag mus rau hauv Suav lag luam hauv xyoo 2002. Hauv 2021, lub ntiaj teb kev muag khoom ntim ntawm Mesna ntsig txog formulations yog kwv yees li $ 41.7 lab. Muaj ntau qhov kev pom zoo versions ntawmMesna raw khoomnyob rau hauv Suav teb, thiab Hengrui Pharmaceuticals pib qhov kev ntsuam xyuas qhov sib xws ntawm cov khoom no hauv xyoo 2020, ua rau nws yog thawj lub lag luam.
Mesna yog dab tsi?
Sodium 2-mercaptoethanesulfonateyog cov hmoov dawb hygroscopic nrog cov ntxhiab tsw, uas yooj yim oxidized, tshwj xeeb tshaj yog nyob rau hauv ib puag ncig ntub. Thaum nyob rau hauv kev sib cuag nrog oxygen, nws sai sai decomposes rau hauv dimes sodium (Equation II). Nws yog ib qho kev pabcuam siv tshuaj tiv thaiv qog, thiab tuaj yeem siv los ua cov tshuaj tiv thaiv urethral.
Nws lub hauv paus ntsiab lus ntawm kev ua yog:Mesna raw hmoovUa ke nrog cov tshuaj lom neeg xws li acrolein, metabolite ntawm ifosfamide thiab cyclophosphamide tom qab siv ntau npaum li cas, ua kom muaj kev ruaj khov thiab tsis muaj tshuaj lom thioether, uas tuaj yeem tawm nrog cov metabolism, yog li tiv thaiv thiab txo cov tsos mob ntawm hemorrhagic cystitis tshwm sim los ntawm nws.
Lub hom phiaj ntawm cov khoom pom zoo yog dab tsi?
Lub hom phiaj ntawm cov khoom no yog los tiv thaiv cov kev mob tshwm sim ntawm urological squamous hlwb xws li exudative cystitis tshwm sim los ntawm kev siv tshuaj khomob thiab xov tooj cua rau cov qog nrog kev thov siab rau cyclophosphamide lossis ifosfamide. Nws tuaj yeem siv los ua cov yeeb yaj kiab tiv thaiv rau cov zis thaum siv ua ke nrog cov tshuaj tiv thaiv qog noj ntshav ifosfamide lossis cyclophosphamide.
Mesna zoo ib yam li Cystine acid-Cystine hauv physiology. Nyob rau hauv tib neeg lub cev, cov tshuaj sai dhau mus rau catalytic cov tshuaj tiv thaiv tus nqi ntawm enzyme los ua nws hom compound mesna disulfide. Mesna kuj tuaj yeem cuam tshuam nrog lwm yam hauv cov poov tshuaj thiocyanate (xws li cystine) los tsim cov disulfide sib xyaw. Hom disulfide no tuaj yeem txo qis ntawm cov poov tshuaj thiocyanate ib ntus hauv cov ntshav. Tom qab siv cov khoom no, tsuas yog ib qho me me ntawm cov tshuaj kho mob muaj nyob rau hauv cov hlab ntsha hauv lub cev ua pa hauv daim ntawv ntawm potassium thiocyanate. Mesna disulphide yog qhov ruaj khov, nws nkag mus rau hauv lub cev ua pa thiab thauj mus rau lub raum ua haujlwm sai. Nyob rau hauv lub raum tubular squamous epithelial hlwb, ntautshuaj disulfidesyog remelted rau hauv dawb poov tshuaj thiocyanate. Ua li no, mesna tuaj yeem tswj lub zais zis ua ke nrog cyclophosphamide, ifosfamide 4- hydroxy compounds thiab acrolein hauv cov zis.
Cov ntaub ntawv hauv kab lus no yog los ntawm Is Taws Nem thiab tsis siv los ua cov lus qhia txog kev kho mob lossis cov lus qhia peev. Yog tias tsab xov xwm no muaj kev cuam tshuam rau koj txoj cai thiab kev txaus siab lossis xav paub txog cov khoom no, thov hu rau peb raws sijhawm kom peb tuaj yeem muab kev pab ntxiv rau koj