ARA-290 peptide yog dab tsi?
Xi'an Faithful BioTech Co., Ltd. yog nyob hauv Xi'an, qhov chaw yug ntawm txoj kev Silk Road thaum ub. Leveraging lub nroog lub mature logistics network thiab nplua chemical industrial resources, peb lub lag luam tau loj hlob mus rau hauv ib tug integrated zoo tshuaj muab kev pab cuam uas xa cov khoom mus rau lub ntiaj teb no cov neeg koom tes.ARA-290 peptideyog ib tug linear hluavtaws polypeptide tsim los ntawm 11 amino acids, nrog cov kab ke pE-Q-L-E-R-A-L-N-S-S-OH. Nws cov qauv molecular yog tsim los ntawm cov khoom ua haujlwm ntawm Helix-B nto ntawm erythropoietin. Los ntawm kev hloov pauv molecular, nws tsuas yog ua rau ntawm qhov kho qhov muag tsis pom kev (IRR) yam tsis muaj kev txhawb nqa erythropoiesis, yog li ua kom muaj kev sib cais thiab kev tshuaj xyuas ntawm cov cim ua haujlwm. Cov tshuaj no feem ntau yog cov hmoov dawb nrog cov dej zoo solubility thiab ib txwm purity tshaj 98%. Nws yog qhov tsim nyog rau kev khaws cia ntawm -20℃hauv qhov chaw kaw, tiv thaiv lub teeb, thiab qhov chaw qhuav. Lub innate kho receptor yog ib tug heterodimeric protein complex, thiab nws cov lus qhia yog upregulated thaum lub hlwb ntsib sab nraud kev nyuaj siab los yog cov ntaub so ntswg puas. ARA-290 tuaj yeem xaiv qhib qhov receptor no, pib muaj feem cuam tshuam rau hauv lub cev kev taw qhia txoj hauv kev thiab pab txhawb rau kev tshawb fawb ntsig txog cellular lub xeev tu thiab cov ntaub so ntswg rov qab.
Kev siv ARA-290 peptide
ARA-290 peptide(CAS 1208243-50-}8), ib qho hluavtaws polypeptide uas xaiv los ua kom lub cev kho cov receptors, feem ntau yog siv hauv ntau yam kev tshawb fawb hauv chav kuaj. Nws feem ntau yog siv los tshawb nrhiav cov txheej txheem ntsig txog neural, ua kev tshawb fawb dav dav ntawm cov paj hlwb me me thiab cov qauv paj hlwb peripheral. Nws kuj tseem tuaj yeem siv rau cov kev sim cuam tshuam txog kev ntsuas kev ntsuas receptor, cov lus teb ntawm cellular stress, thiab kho vascular thiab cov ntaub so ntswg. Tsis tas li ntawd, nws yog siv rau cov qauv metabolic ntsig txog thiab cov kab mob ntawm cov hlab ntsha hauv cov hlab ntsha los tshawb txog cov xwm txheej ntawm cov ciaj sia taus, fiber ntau, thiab cov kev hloov pauv hloov pauv hloov pauv, muab cov cuab yeej sim rau kev tshawb fawb txog kev ua haujlwm ntawm polypeptide thiab receptor kev sib cuam tshuam mechanisms.
COA
| Cov khoom kuaj | Specification | Kev Xeem |
| Qhov tshwm sim | Dawb hmoov | Dawb hmoov |
| Purity (HPLC) | Ntau dua lossis sib npaug li 98.0% | 99.12% |
| Cov ntsiab lus dej (Karl Fischer) |
Tsawg dua lossis sib npaug li 5.0% | 2.15% |
| Cov ntsiab lus Acetate | Tsawg dua lossis sib npaug li 8.0% | 5.32% |
| Ib leeg impurity | Tsawg dua lossis sib npaug li 1.0% | 0.45% |
| Tag nrho cov impurities | Tsawg dua lossis sib npaug li 2.0% | 0.88% |
| Xaus | Ua raws li kev lag luam specification | |
Nyem email:sales4@faithfulbio.comLos yog WhatsApp:+86 17782784907
Qhov ceev 1.56 ± 0.1 g / cm3 (Predicted)
Cov roj formula: C51H84N16O21
Molecular Luj: 1257.31
1256.599731
LogP - 6.59
InChIKey WZTIQQBMSJTRBR-WYKNNRPVSA-N
Mechanism ntawm kev txiav txim ntawm ARA-290 peptide
Receptor-kev lees paub xaiv:ARA-290 peptideSelectively khi rau lub innate kho receptor IRR, ib tug heterodimeric complex ntawm EPOR thiab CD131, uas nws qhia tau upregulated nyob rau hauv cov ntaub so ntswg kev nyuaj siab thiab raug mob. Cov qauv tsim molecular zam cov classic EPOR homodimer, yog li tiv thaiv qhov tshwm sim ntawm erythrocyte proliferation -txog txoj kev taw qhia.
Intracellular signaling pathway pib: Tom qab khi rau lub receptor, lub peptide activates intracellular signaling cascades xws li JAK2-STAT thiab PI3K / Akt, tswj downstream gene qhia, cuam tshuam cell viability thiab cytokine secretion, thiab modulating lub zos microenvironment teeb liab transduction.
Kev tswj hwm microenvironment hauv zos: Nws tuaj yeem tswj hwm cov lus qhia theem ntawm ntau yam cytokines, hloov kho lub xeev kev ua haujlwm ntawm lub cev tiv thaiv kab mob thiab microglia, hloov cov qauv tso tawm ntawm cov teeb liab hauv zos, thiab txhim kho microenvironmental tej yam kev mob hauv cheeb tsam puas.
Cellular lub xeev kev saib xyuas: Los ntawm cov kev taw qhia qis qis, nws pab tswj cov cellular homeostasis, txo cov cell poob los ntawm kev ntxhov siab sab nraud, pab ntau hom ntawm tes xws li paj hlwb thiab endothelial hlwb hauv kev tswj hwm lub cev lub cev, thiab muab lub hauv paus rau kev hloov kho cov qauv fibrous.
Kev cai ntawm neural signals: Nws ua rau peripheral thiab qaum qaum -txog paj hlwb, tswj ion channel thiab glial cell kev ua, thiab koom nrog cov kev cai ntawm cov teeb liab ntsig txog paj hlwb kev loj hlob thiab kev kho cov qauv, muab cov cuab yeej molecular rau neural -cov qauv kev tshawb fawb.
Spatial targeting yam ntxwv: IRR feem ntau yog upregulated nyob rau hauv puas thiab stressed cov ntaub so ntswg. Cov kev taw qhia cov nyhuv ntawm peptide yog ntau concentrated nyob rau hauv perturbed cov ntaub so ntswg qhov chaw, nrog kuj txwv kev cuam tshuam rau cov ntaub so ntswg noj qab nyob zoo.
vim li cas xaiv peb
Peb ua raws li lub hauv paus ntsiab lus ntawm "cov neeg siv khoom ua ntej, ua siab ncaj ua ntej", thiab ib txwm muab cov neeg siv khoom nrog cov khoom zoo thiab muaj txiaj ntsig zoo thiab siab - cov kev pabcuam zoo. Xaiv kev ncaj ncees. Xaiv lub neej noj qab nyob zoo!
Nrog rau peb cov kev siv zog tas mus li thiab kev pabcuam zoo, peb cia siab tias yuav tsim kom muaj kev koom tes ntev - thiab kev loj hlob zoo nrog cov neeg siv khoom thiab muab sijhawm rau peb. Peb ntseeg tias peb yuav ua rau koj txaus siab rau thawj -chav kawm zoo, nyab xeeb thiab xa khoom sai thiab txaus siab tom qab- kev muag khoom.
Shipping Txoj Kev
| Tsheb thauj mus los | Shipping txoj kev | Cargo hnyav xav tau | Qhov zoo |
| 3-7 hnub | DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, UPS, USPS, FedEx, TNT, EMS |
Haum rau qis dua 50kg. International qhov rooj rau qhov rooj nthuav qhia |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, thiab cov neeg muas zaub nyob rau hauv cov teb chaws Europe thiab America yuav txaus siab rau xa cov khoom ncaj qha los ntawm ob qhov chaw. |
| 7-15 hnub | Los ntawm Cua | Haum rau ntau tshaj 50kg. ceev thiab pheej yig dua rau kev txiav txim loj |
|
| 15-60 hnub | Los ntawm Hiav Txwv | Haum rau ntau tshaj 500kg. Kev xa khoom pheej yig tshaj plaws |
FAQ
01. Lub receptor twg ARA-290 feem ntau ua rau?
Nws yog lub hom phiaj ntawm kev kho lub cev tsis muaj zog IRR, uas yog heterodimer muaj li ntawm EPOR thiab CD131. Nws tsis qhib erythrocyte proliferation -txoj kev cuam tshuam.
02. Yam kev tshawb fawb twg yog ARA-290 haum rau?
ARA-290 peptideFeem ntau yog siv rau hauv cov kev sim hauv paus xws li kev tshawb fawb neural qauv, receptor pathway tsom, cellular stress teb, kho cov ntaub so ntswg, corneal paj hlwb, thiab cov qauv metabolic.
03. Vim li cas ho tsis ARA-290 cuam tshuam rau cov txheej txheem erythrocyte?
ARA-290 peptide molecule tau raug hloov kho los ntawm kev xaiv fragment kom paub txog tsuas yog IRR heterodimer thiab tsis ua rau EPOR homodimer; Yog li ntawd, nws tsis pib erythrocyte ntau lawm-txog teeb liab.
Nyem email:Sales4@Faithfulbio.ComLos yog WhatsApp:+86 17782784907
Tsis lees paub:Tag nrho cov khoom lag luam (tsis yog- cov khoom raug cai) cov duab raug coj los ua zoo, tab sis vim yog lub zog ntawm lub teeb (lub sijhawm sib txawv, lub teeb tom qab sib txawv), txoj kev tua, cov khoom siv sib txawv thiab lwm yam, tej zaum yuav muaj qee qhov sib txawv ntawm daim duab thiab cov xim tiag tiag, cov xim ntawm cov khoom, thov coj cov nyhuv tiag tiag, xim txawv ntawm cov khoom tsis yog qhov teeb meem zoo.
Nco tseg:Nco ntsoov sab laj nrog tus kws kho mob uas tsim nyog ua ntej noj cov tshuaj tshiab. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho lossis tiv thaiv txhua yam kab mob.Thaum lub sijhawm yuav khoom, tus neeg yuav khoom thoob ntiaj teb pom zoo xav tias muaj kev pheej hmoo ntawm txhua yam khoom tuaj txog. Peb tsis tuaj yeem hloov cov khoom ploj lossis raug kaw. Ua ntej xa cov khoom, koj yuav tsum paub meej tias koj pom zoo rau cov nqe lus no.Qhov no tsuas yog kev pom zoo koob tshuaj raws li peb tus kheej kev paub thiab cov ntaub ntawv pov thawj. Peb pom zoo kom koj ua koj tus kheej kev tshawb fawb ua ntej siv cov khoom no.
Nqe lus:Cov khoom no tsuas yog siv rau kev tshawb fawb tshawb fawb, thiab qhov tshwm sim ntawm lwm yam kev siv tsis muaj lub luag haujlwm.
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