Spadin Peptide CAS 1270083-24-3

SPADIN yog lub ntuj peptide muab los ntawm propeptide tso tawm los ntawm cov hlab ntsha thiab yog ib qho zoo TREK-1 channel blocker nrog IC50 tus nqi ntawm 10 nM. Cov kev tshawb fawb tau qhia tiasSpadin Peptide hmoovtuaj yeem thaiv cov haujlwm ntawm TREK-1 (KCNK2 lossis K2P2.1) raws. Spadin tshwj xeeb khi rau TREK-1 los txhim kho 5-HT neurotransmission nyob rau hauv dorsal raphe nucleus ntawm nas, inducing hippocampal CREB activation thiab neurogenesis. Clinically, nws tuaj yeem siv rau kev tshawb fawb ntawm cov khoom siv tshuaj tiv thaiv kev ntxhov siab.

Dab tsi yog qhov zoo thiab qhov tsis zoo ntawm Spadin Peptide piv rau lwm cov TREK-1 channel blockers?

Piv rau lwm cov TREK-1 channel blockers, spadin muaj qhov zoo sib xws:
1.High Selectivity:Spadin yog ib qho kev xaiv TREK-1 blocker (IC₅₀ ≈ 10 nM) uas tsis cuam tshuam rau lwm K2P channel xws li TREK-2, TRAAK, TASK-1, lossis TRESK. Qhov tshwj xeeb no yog qhov zoo tshaj rau ntau yam me me-molecule inhibitors (xws li, SID1900, lig4-4) uas feem ntau muaj kev sib raug zoo qis dua thiab muaj kev cuam tshuam ntau dua.
2.Rapid Antidepressant Action:Hauv cov qauv nas, spadin induces antidepressant -zoo li cov teebmeem hauv 4 hnub, pib sai dua li 2-3 lub lis piam uas feem ntau xav tau rau cov tshuaj antidepressants. Qhov kev txiav txim sai no yog vim nws lub peev xwm nce 5-HT neuron firing hauv dorsal raphe nucleus thiab txhawb nqa hippocampal neurogenesis.
3.Favorable Safety Profile:Txawm hais tias TREK-1 tshem tawm tau cuam tshuam nrog qhov mob rhiab heev, qaug dab peg, thiab ischemia, spadin tsis cuam tshuam cov kev mob tshwm sim hauv cov qauv tsiaj. Nws kuj tsis cuam tshuam rau lub plawv ua haujlwm lossis ntshav siab, qhia txog lub qhov rais kev nyab xeeb zoo dua li cov blockers tsis xaiv.

Piv rau lwm cov TREK-1 channel blockers, spadin muaj qhov tsis zoo:

1.Peptide txwv:Raws li peptide, spadin muaj qhov tsis zoo ntawm bioavailability thiab ib nrab luv luv -lub neej, txwv nws cov khoom siv kho mob. Thaum nws cov retro-inverso analogs thiab luv luv fragments qhia txhim kho stability thiab potency, lawv tseem sim.

2.Limited Clinical Data: Spadin Peptide hmoovtseem nyob rau theem kev tshawb fawb preclinical, tsis muaj kev pom zoo siv tshuaj kho mob. Hauv qhov sib piv, qee qhov tsis yog - xaiv TREK-1 blockers (xws li:fluoxetine) twb tau tsim cov tshuaj tiv thaiv kev nyuaj siab, txawm tias lawv muaj qhov pib qeeb dua thiab muaj kev phiv ntau dua

Dab tsi yog qhov txawv ntawm SPADIN Peptide hmoov thiab Vortioxetine?

SPADIN thiab Vortioxetine yog ob qho tib si sib txawv ntawm cov khoom siv tshuaj tiv thaiv kev ntxhov siab raws li lawv cov txheej txheem ntawm kev ua, hom molecular, thiab theem kho mob.Vortioxetine hmoovyog ib qho lag luam me me molecule multimodal antidepressant uas txhim kho cov tsos mob ntawm kev nyuaj siab thiab kev paub txog kev ua haujlwm los ntawm inhibiting serotonin (5-HT) reuptake thiab tswj ntau 5-HT receptors (xws li ua kom 5-HT1A, ib feem ua kom 5-HT1B, antagonizing, thiab lwm yam). Nws yog qhov tsim nyog rau thawj kab kev kho mob ntawm cov neeg laus kev nyuaj siab hnyav, nrog rau cov kev phiv tshwm sim xws li xeev siab thiab mob taub hau, tab sis qhov kev pheej hmoo ntawm kev sib deev tsis zoo thiab qhov hnyav nce kuj tsawg.SPADIN Peptide hmoovyog lub ntuj peptide tseem nyob rau theem kev tshawb fawb preclinical, uas txhim kho 5-HT neurotransmission thiab txhawb nqa hippocampal neurogenesis los ntawm kev xaiv thaiv TREK-1 potassium channels. Nws tau qhia txog qhov muaj peev xwm tshwm sim sai (txog 4 hnub) hauv cov qauv tsiaj, thiab tsis muaj qhov tseem ceeb ntawm cov hlab plawv lossis qhov mob cuam tshuam txog kev mob tshwm sim. Txawm li cas los xij, vim nws cov khoom peptide, nws cov bioavailability tsis zoo thiab nws ib nrab-lub neej luv luv. Tam sim no, nws tsuas yog txhim kho cov tshuaj pharmacokinetic los ntawm kev hloov kho cov qauv, thiab tseem tab tom kho thiab tseem tsis tau nkag mus rau hauv daim ntawv thov kho mob.

Muaj ntau txoj kev xa khoom rau koj xaiv

Peb lub zog:

Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub Hoobkas thiab chaw kuaj hauv Suav teb, Peb lub tuam txhab tuaj yeem muabSpadin Peptide hmoovthiab lwm yam ntawm tus nqi zoo dua. Yog tias koj txaus siab, thov sau ib tsab ntawv.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.

FAQ:

Q1: Cov khoom ntim li cas?​

Peb siv discreet, unmarked txheej ntim. Internally, tag nrho cov khoom yog muab ob npaug rau- kaw rau hauv tsis muaj menyuam, pob tshab lub hnab kom huv si thiab kev ncaj ncees. Peb cov txheej txheem ntim tau ua tib zoo ua kom zoo kom muaj kev tshaj lij thiab qis -cov duab profile.

Q2: Koj puas tuaj yeem lees paub cov lus txiav txim nrog peb ua ntej xa khoom?​

Yog lawm. Txhua yam khoom tau ua tib zoo sau npe, thiab peb yuav rov lees paub txhua yam kev txiav txim nrog koj ua ntej xa.

Q3: Puas yuav tsum tau kos npe thaum xa khoom?​

Tsis yog. Peb txoj kev xa khoom txheem tsis tas yuav tsum tau kos npe thaum xa khoom. Yog tias koj xav tau kos npe rau - yuav tsum muaj kev pabcuam, thov hu rau peb ua ntej kom npaj tshwj xeeb.

Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.

Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.

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