Trofinetide yog dab tsi?
Trofinetide yog ib qho hluavtaws analogue ntawm amino-terminal tripeptide ntawm insulin-zoo li kev loj hlob zoo, uas yog lub hom phiaj los pab txhawb rau cov tsos mob tseem ceeb ntawm Rett syndrome los ntawm kev txo qis neuroinflammation thiab txhawb kev ua haujlwm synaptic. Thaum Lub Peb Hlis 2023, nws tau pom zoo los ntawm US FDA.
TrofinetideNws yog tsim rau cov neeg laus thiab cov menyuam yaus hnub nyoog qis dua 2 xyoos nrog Reiter's syndrome. Reiter's syndrome yog ib qho tsis tshua muaj tshwm sim los ntawm cov kab mob neurodevelopmental, feem ntau tshwm sim los ntawm kev hloov ntawm MECP2 noob, uas cuam tshuam rau kev loj hlob ntawm lub paj hlwb thiab ua rau lub cev muaj zog, kev txawj ntse thiab kev hais lus tsis zoo.
| Khoom npe |
Trofinetide |
| CAS | 853400-76-7 |
| Cov mis mos molecular | C13H21N3O6 |
| Molecular hnyav | 315.32 |
| melting point | 144 degree |
| kub point | 655.4 ± 55.0℃(Predicted) |
| ceev | 1.377 ± 0.06 g / cm3 (Tshaj tawm) |
| Solubility | dej (me ntsis soluble) |
| Lub acidity coefficient (PKA) | 3.51 ± 0.10 (Kev kwv yees). |
| Kev cia khoom | Muab kaw rau hauv qhuav, Chav Kub |
Qhov kev txiav txim ntawm Trofinetide yog dab tsi?
Trofinetide yog ib qho tshuaj peptide hluavtaws nrog ntau- lub hom phiaj neuroprotective nyhuv, thiab nws cov txheej txheem ntawm kev ua yog tsuas yog paub los ntawm cov hauv qab no:
Molecular qauv thiab yooj yim mechanism
Nws yog ib qho endogenous hluavtaws analog, thiab unnatural amino acid (S) -2-methylpyrolidine-2-carboxylic acid hydrochloride yog siv los hloov DL-Proline nyob rau hauv natural compounds. Qhov kev hloov kho cov qauv no ua rau nws muaj cov yam ntxwv pharmacokinetic zoo dua.
Ntau- phiaj xwm kev tiv thaiv kab mob
1. Synaptic muaj nuj nqi tswj
Trofinetidetuaj yeem txhim kho kev ua haujlwm synaptic, rov kho cov qauv synaptic, thiab txhim kho cov haujlwm neuron los ntawm kev nce dendrite branching thiab synaptic plasticity signals.
2. Neuroinflamation inhibition
Los ntawm kev tswj cov teeb liab txoj kev, nws cuam tshuam cov lus teb neuroinflammatory. Kev ua haujlwm tshwj xeeb yog raws li hauv qab no:
Inhibit phosphorylation thiab down - tswj kev tso tawm ntawm cov tshuaj proinflammatory
Qhov tseem ceeb txo cov theem ntawm cov kab mob inflammatory thiab inhibit qhov kev qhia ntawm microglia activation marker Iba-1.
3. Inhibition ntawm neuronal apoptosis
Nws ua lub luag haujlwm tiv thaiv -apoptosis los ntawm kev tswj cov kev qhia ntawm apoptosis-txog cov proteins:
4. Pathological kev tswj ntawm amyloid protein
Nyob rau hauv tus qauv ntawm Alzheimer's kab mob, nws inhibits -secretase kev ua si los ntawm activating PPAR- txoj kev, yog li txo qhov ntau lawm thiab deposition ntawm A .
5. Antioxidant kev nyuaj siab
Trofinetidetuaj yeem ua rau cov tshuaj tiv thaiv antioxidant, txo oxidative kev nyuaj siab puas tsuaj thiab tiv thaiv neurons los ntawm oxidative puas.
Cov kev cai ntawm txoj kev teeb pom kev zoo thiab cov kev tshawb fawb molecular docking qhia tau tias nws muaj kev sib raug zoo siab, uas muab lub hauv paus molecular rau nws cov txiaj ntsig ntau -.
Khoom Specification
| Cov khoom | Specifications | Cov txiaj ntsig |
|
Qhov tshwm sim |
Dawb hmoov | Ua raws |
| Kev ntsuam xyuas (HPLC) | 98.0% -102% | 99.26% |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 0.50% | 0.23% |
|
Hnyav Hlau |
Tsawg dua lossis sib npaug li 20ppm |
<20ppm |
|
Microbial txwv |
Tsawg dua lossis sib npaug li 20ppm |
<20ppm |
| Yeast & Pwm | Tsawg dua lossis sib npaug li 50cfu / g | <10cfu/g |
| Coliforms | Tsawg dua lossis sib npaug li 3cfu / g | <3cfu/g |
| E. Coli | Negative / 10g | Tsis zoo |
| Salmonella | Tsis zoo / 25g | Tsis zoo |
| S.aureus | Tsis zoo / 25g | Tsis zoo |
| Xaus: Cov qhabnias xeem tau ua raws li hauv -lub tsev specification | ||
Yuav ua li cas thiab qhov twg yuav Trofinetide wholesale?
Koj tuaj yeem tso siab rau peb tag nrho vim tias peb muaj cov ntaub ntawv zoo hauv kev muag tshuaj qhia kev cai lij choj. Tau ntau xyoo, peb tau mus txog Ntau qhov kev txiav txim siab kev koom tes ntawm Tebchaws Europe thiab Amelikas, uas muaj kev nyab xeeb thiab ceev ceev. Muaj kev ruaj ntseg.
Yog vim li cas rau xaiv peb:txhim khu kev qha lub zog mov, zoo siab thiab ruaj khov cia, txhawj xeeb- khoom pub dawb thiab xa khoom raws sijhawm tom qab muag.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales7@faithfulbio.comTam sim no.
Muaj ntau txoj kev xa khoom rau koj xaiv
|
Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
|
7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
|
|
15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv , Nyem email: sales7@faithfulbio.com Tam sim no.
FAQ:
Q1: Koj puas tuaj yeem muab cov qauv rau kev kuaj xyuas zoo thiab kev sim?
A1:Tau kawg. Peb txaus siab muab cov qauv dawb rau koj qhov kev ntsuam xyuas rau cov neeg muaj peev xwm tiag tiag. Cov neeg muas zaub yuav tsum tau dais lub thoob ntiaj teb freight. Thov xa tus qauv daim ntawv thov los ntawm peb lub lag luam email.
Q2: Tus nqi yog dab tsi?
A2:Tus nqi sib txawv raws li qhov ntau npaum li cas, cov khoom specifications (qib purity) thiab ntim khoom. Thov qhia rau peb paub koj cov kev xav tau tshwj xeeb thiab peb yuav muab cov lus sib tw rau koj.
Q3: Koj ntim koj cov khoom li cas?
A3: Peb siv ntau- txheej ntim ntim kom ntseeg tau tias cov khoom muaj kev tiv thaiv los ntawm ya raws thiab tsis zoo thaum thauj thiab khaws cia. Sab hauv txheej yog kaw nrog ob lub hnab polyethylene. Nruab nrab txheej: aluminium foil hnab. Txheej txheej: noo noo- pov thawj HDPE yas thoob los yog cov thoob yas.
Tsis lees paub: Cov lus tshaj tawm hauv lub vev xaib no yog siv rau kev kawm tshawb fawb thiab kev sib tham, uas yog dialectical thiab tsis txhais hais tias lub vev xaib no pom zoo nrog tag nrho nws cov kev xav. Thov ua tib zoo tshuaj xyuas. Yog tias muaj kev ua txhaum cai lossis lwm yam kev tsis txaus siab, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.
Nco ntsoov:Nws yuav tsum raug sau tseg tias cov khoom no tsis yog npaj rau kev kuaj mob, kev kho mob, kev kho, lossis kev tiv thaiv kab mob. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv. Thov tsis txhob siv yam tsis tau kev tso cai. Cov tshuaj no tsuas yog siv rau kev tshawb fawb lub hom phiaj. US Food and Drug Administration tsis tau soj ntsuam cov lus thov no.
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