Dab tsi yog cov hmoov tswm ciab?
Candesartan hmoov, ib tug prodrug ntawm candesartan ester, yog ib tug sai sai tsim tshiab chav kawm ntawm cov tshuaj uas ua rau renin-angiotensin system (RAS) tom qab angiotensin-hloov enzyme inhibitors (ACEIs). Vim nws lub peev xwm los xaiv los thaiv angiotensin II receptors nyob rau hauv lub circulatory system thiab cov ntaub so ntswg, nws muaj zoo antihypertensive teebmeem thiab tsawg dua cov kev phiv, ua rau nws yog ib tug cog lus antihypertensive tshuaj.
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Khoom npe |
Candesartan |
|
Cas |
39481-59-7 |
|
|
Cov mis mos molecular |
C24H20N6O3 | |
|
Molecular hnyav |
440.45 | |
|
Einecs tooj |
604-138-8 | |
|
Chaw Cia Khoom |
Inert huab cua, chav tsev kub |
|
|
Kev tshwm sim |
Cov hmoov dawb |
|
|
Melting taw tes |
183-185 degree |
|
| Kub taw tes | 754.8 ± 7 {0. 0 degree c (kwv yees) |
Dab tsi yog pharmacology thiab kev siv ntawm Candesartan hmoov?
1. Candesartan medoxomil yog hydrolyzed sai sai rau hauv cov metabolite candesartan hauv lub cev. Candesartan yog angiotensin II receptor (AT1) antagonist uas antagonizes vasoconstrictive nyhuv ntawm angiotensin II los ntawm kev khi rau AT1 receptor nyob rau hauv vascular du nqaij, yog li txo peripheral vascular kuj. Lwm qhov kev pom yog tias candesartan tuaj yeem siv qee yam tshuaj tiv thaiv kab mob los ntawm inhibiting qhov tso tawm ntawm aldosterone hauv cov qog adrenal.
2. Cov kev sim ua hauv cov neeg mob ntshav siab tau pom tias rov siv cov khoom no tuaj yeem ua rau muaj kev nce hauv cov ntshav renin kev ua haujlwm, angiotensin I concentration, thiab angiotensin II concentration; Noj 2-8mg ntawm cov khoom no ib zaug ib hnub tsis tu ncua tuaj yeem txo cov ntshav siab systolic thiab diastolic, txo qis ventricular myocardial hnyav thiab peripheral vascular tsis kam, tab sis tsis muaj kev cuam tshuam tseem ceeb ntawm lub plawv tso zis, ejection feem, lub raum vascular kuj, raum ntshav khiav. , thiab glomerular pom tus nqi; Rau cov neeg mob ntshav siab thawj zaug thiab mob cerebrovascular, nws tsis muaj kev cuam tshuam rau cov ntshav cerebral.
Dab tsi yog kev siv ntawmKhoom tsis zoo?
Candesartan hmoovyog cov tshuaj kho kom dav los kho ntshav siab (ntshav siab) thiab lub plawv tsis ua haujlwm.
Nws pab tiv thaiv kev mob stroke yav tom ntej, mob plawv thiab teeb meem raum. Nws kuj tseem txhim kho koj txoj sia nyob yog tias koj noj nws rau lub plawv tsis ua haujlwm.
Muaj qee cov pov thawj uas tswm ciab yuav pab tiv thaiv kev tu ncua.Tiamsis, tswm ciab tswm ciab tsis tau pom zoo rau niam
Yog tias koj xav tau, koj tuaj yeem nyem email:sales1@faithfulbio.com
Khoom Qhia Txog Khoom
|
Yam |
specification |
Kev tshwm sim |
|
Lcms |
Sib xws nrog cov qauv |
Ua raws |
|
Qhov tshwm sim |
Dawb mus rau dawb hmoov |
Ua raws |
|
Purity |
Nlt 98% (ntawm ziab) |
98.9% |
Yuav ua li cas rau synthesizeCandesartan hmoov?
(1) los ntawm 2-amino-3-nitrobenzene methyl thiab 4-aldehyde radical-2-biphenylcarbonitriles hauv cov kuab tshuaj organic, kub tswj tau nyob rau hauv 0 ~ 5 degree tus mob, generates 2-[[2 '-cyanobiphenyl-4-yl los ntawm condensation cov tshuaj tiv thaiv] methylene amino]-the 3-nitrobenzene methyl (I);
(2) compound (I) react hauv autoclave nrog 10% palladium carbon, nrog nitrogen hloov cua 3 zaug, siv hydrogen pauv nitrogen 5 zaug, logical hydrogen rau 0.20 ~ 0.25MPa yog sov mus txog 40 ~ 45 degree ntawm cov tshuaj tiv thaiv thiab txo kom tau 2-[[2 '-cyanobiphenyl-4-yl dua] methyl] amino]-the 3-Methyl anthranilate (II);
(3) compound (II) yog rhuab mus rau 80 degree nrog tetraethyl orthocarbonate, reacts cyclization nyob rau hauv 1 teev thiab tau txais 1-[(2 '-cyanobiphenyl-4-yl) methyl]-2-oxyethyl pawg -1H-benzoglyoxaline-7-carboxylate methyl ester (III);
(4) compound (III) nrog kev hloov nitrogenize tin cov tshuaj tiv thaiv Tetrazole lub nplhaib rau hauv, tau}}}} tetrazolium {{} yl) Xenyl -4-} yl] Methyl] Benzoglyoxaline {9}} carboxylic acid, Ethyl Ester (IV);
(5) Compound (IV) Hydrolysis ua Generates {1}}}}}}}}}}} yl nyob rau hauv alkaline) methyl] Benzoglyoxaline -7- cov kua roj carboxylic acid (v);
(6) compound (V) hnov mob nrog triphenylmethyl chloride thiab triethylamine hydrochloride, los ntawm N-tiv thaiv cov tshuaj tiv thaiv, tau cov compound 2-oxyethyl pawg-1-[[2 ,-(1-trityl tetrazole{ {7}}yl) xenyl-4 base] methyl] benzoglyoxaline-7-carboxylic acid (VI);
(7) Compound (VI) los ntawm Esterification, tsim cov compound {1}}}}} yl)} {} Base] Methyl] Benzoglyoxaline {8}} lyclohexyl oxygen Pa,}}} oxygen Pad] Cov pa oxygen (vii);
(8) compound (VII) Kev tsis txaus ntseeg tau txais cov compound ({}}}}} yl) [1, l '-biphenyl l { {10} ¢] Methyl] {{h-}}}}}}} ecyen (viii) .finally, tauCandesartan hmoov.
Yuav ua li cas thiab qhov twg yuavCandesartan hmoovKev lag luam wholesale?
Peb muaj 8 xyoo kev paub hauv kev muag cov tshuaj tshawb fawb txog kev cai lij choj thiab muaj lub koob npe zoo, ua rau peb tus khub uas ntseeg siab.
Peb paub tseeb tias qhov zoo ntawm peb cov khoom los ntawm kev sim ua haujlwm ywj pheej, thiab txhua tus neeg siv khoom yog peb VIP.
Xa koj qhov kev nug kom paub ntau ntxiv, Nyem Email:sales1@faithfulbio.comTam sim no.
Muaj ntau txoj kev xa khoom rau koj xaiv
|
Tsheb thauj mus los |
Shipping Txoj Kev |
Cargo Qhov hnyav |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
|
7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
|
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Tsis lees paub: Cov lus ntawm lub vev xaib no yog siv rau kev tshawb fawb thiab kev kawm sib pauv. Thov ua tib zoo saib pom qhov tseeb ntawm lawv cov kev xav thiab cov ntsiab lus. Yog tias koj pom muaj kev ua txhaum. Thov hu rau tus thawj tswj hwm kom sai. Peb tsis yog lub luag haujlwm rau cov kev rau txim ntawm cov ntaub ntawv thiab cov kev pabcuam tau muab rau hauv lub vev xaib no.
Tsab ntawv: Cov khoom lag luam yog rau kev tshawb fawb tsuas yog siv thiab tsis yog rau kev kuaj mob, kev kho mob, tiv thaiv kab mob, thiab lwm yam.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales1@faithfulbio.comTam sim no.
Cim npe nrov: Cov Khoom Taw Kiab Hmoov Li {139481-59-7, Cov Khoom Siv, Chaw Tsim Tshuaj, Tsim Nyog, Khoom Siv Dawb, Khoom Siv Raw, Ua Rau Hauv Phiaj suav