Khoom piav qhia
Dexibuprofen hmoovyog cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj (NSAID). Nws yog lub active txoj cai enantiomer ntawm ibuprofen. Feem ntau cov kev npaj ibuprofen muaj ib tug racemic sib tov ntawm ob isomers.
Dexibuprofen hmoovyog chiral hloov rau racemic ibuprofen. Raws li txoj cai Cahn-Ingold-Prelog, qhov kev teeb tsa ntawm chiral carbon hauv dedexbuprofen yog (S). Decibuprofen tseem hu ua S(+) ibuprofen. Decibuprofen yog siv los txo qhov mob ntawm osteoarthritis, rheumatoid mob caj dab thiab lwm yam mob. Nws kuj yog siv los kho mob me mus rau nruab nrab kub taub hau thiab mob. Tsis txhob siv cov tshuaj no yog tias koj muaj mob los ntshav, mob hawb pob, lossis kev ua xua.
Ibuprofen yog ib qho alpha-arylpropionic acid uas feem ntau yog siv los kho mob rheumatoid mob caj dab, tab sis kuj tau siv dav hauv khw muag khoom los kho mob taub hau thiab mob me thiab mob. Cov tshuaj muaj ib qho chaw chiral uas muaj nyob rau hauv khub ntawm enantiomers. (5) - ibuprofen yog cov tshuaj yeeb tshuaj uas tsim cov tshuaj kho mob. Qhov tsis muaj zog (R) -enantiomer, uas yog, lub dimer, dhau los ua ib txoj kev chiral inversion kom tau txais cov nquag (S) -enantiomer, nrog rau yav dhau los ua tus prodrug ntawm tom kawg. Ntawd yog, thaum ibuprofen tau tswj hwm raws li kev sib tw sib tw, cov neeg tsis yog haiv neeg tau hloov mus ua ib haiv neeg hauv lub cev, thaum kawg tsis cuam tshuam.
Dexibuprofen hmoov, ib qho S(+) -enantiomer ntawm Ibuprofen, yog lub zog COX-1 thiab COX-2 inhibitor nrog IC50 ntawm 2.1μM thiab 1.6 μM, feem. (S)-(+)-Ibuprofen muaj tshuaj tua kab mob, tiv thaiv kab mob, tshuaj tua kab mob thiab tshuaj tua kab mob.
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COA
| Test lm | Analysis Specification | Kev tshwm sim |
| Kev piav qhia | Dawb crystalline zog | dawb crystalline zog |
| Kev txheeb xyuas | A: lR spectrum yog concordant nrog spectrum ntawm (S)-ibuprofen RS | Ua raws |
| B: Lub sijhawm khaws cia ntawm lub hauv paus ncov yog concordant nrog cov (S)-ibuprofen RS (HPLC) | Ua raws | |
| C: Qhia ob qhov kev nqus siab tshaj plaws ntawm 265nm thiab 273nm, ob qhov kev nqus tsawg kawg ntawm 245nm thiab 271nm thiab lub xub pwg siab ntawm 259nm.(UV) | Ua raws | |
| Melting point | 50~54 | 50 9-51.7 degree |
| Optical kev sib hloov | 55~60 | +57.1 degree |
| Chloride | Tsawg dua los yog sib npaug rau 0.01% | <0.1% |
| Poob rau ziab | Tsawg dua los yog sib npaug rau 0.5% | 0.03% |
| Residue ntawm ignition | Tsawg dua lossis sib npaug rau 0.1% | 0.01% |
| Cov hlau hnyav | Tsawg dua lossis sib npaug li 10ppm | <10ppm |
| Residual kuab tshuaj | Toluene tsis ntau tshaj 800 ppm | 3ppm ua |
| Yam khoom muaj feem | 2-(4-butylphenyl)propionic acid<0.2% | Tsis pom |
| Assay (Dry Basis) |
4-isobutylacetophenone<0.2% | Tsis pom |
| Tag nrho impurities<0.7% | 0.03% | |
| Lwm tus neeg impurity<0.2% | 0.02% | |
| R-ibuprofen Tsawg dua lossis sib npaug li 1.5% | Ua raws | |
| 98.5%-101.0% | 100.00% | |
| Xaus | Ua raws li kev lag luam specification. | |
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Dexibuprofen siv rau dab tsi?
Dexibuprofen yog siv los txo: - mob thiab mob los ntawm osteoarthritis / mob caj dab (mob pob qij txha, sib koom ua ke thiab tsim kua muag); - lub sij hawm (menstrual) mob; - mob me mus rau nruab nrab, xws li mob musculoskeletal, mob taub hau thiab toothache; mob o thiab mob tom qab raug mob.
Puas yog Dexibuprofen zoo dua ibuprofen?
Dexibuprofen yog qhov ua tau zoo thiab zam tau zoo li ibuprofen. Ib koob ntawm 5 mg kg-1 thiab 7 mg kg-1 dexibuprofen nyob rau hauv qhov chaw ntawm 10 mg kg-1 ibuprofen yuav txaus los tswj kub taub hau tshwm sim los ntawm URTI nyob rau hauv cov me nyuam.
Puas yog dexibuprofen muaj kev nyab xeeb?
Dexibuprofen tau ua pov thawj yam tsawg kawg uas muaj txiaj ntsig zoo rau diclofenac, naproxen thiab celecoxib thiab tau pom tias muaj txiaj ntsig zoo. Cov txiaj ntsig tau qhia tias dexibuprofen ua tiav hauv daim ntawv siv lead ua tshwj xeeb yog kev kho kom zoo thiab muaj txiaj ntsig zoo rau cov mob sib txawv.
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vim li cas xaiv peb
Peb lub Hoobkas
Pob
Shipping Txoj Kev
|
Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, thiab cov neeg muas zaub nyob rau hauv cov teb chaws Europe thiab America muaj peev xwm txaus siab rau xa cov khoom ncaj qha los ntawm ob qhov chaw. |
|
7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
|
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
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