Lopinavir yog ib tiam tshiab HIV protease inhibitor tsim thiab txhim kho los ntawm Abbott Laboratories raws li ritonavir. Cov tshuaj tiv thaiv kab mob. Siv los kho tus kab mob HIV-1 rau cov neeg laus thiab cov menyuam yaus hnub nyoog tshaj 6 lub hlis. NtshiabLopinavir hmoovyog dawb rau beige, thiab nws solubility hauv DMSO yog 20mg / mL. Nws tuaj yeem tsis tsuas yog siv rau AIDS virus protease inhibition, tab sis kuj tseem siv tau rau hauv kev sim biochemical, kev sim ua ke thiab lwm yam kev sim.
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lwm |
Specification (USP42 Txuj) |
Kev tshwm sim |
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Qhov tshwm sim |
Dawb hmoov |
Dawb hmoov |
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kev kho hniav |
HPLC: Lub sijhawm khaws cia ntawm cov qauv xeem sib raug raws li tus qauv siv |
Ua raws |
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IR: Lub infrared nqus spectrum ntawm cov qauv kuaj yog concordantwith lub spectrum ntawm kev siv tus qauv |
Ua raws |
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Cov ntsiab lus dej los ntawm KF |
Tsawg dua lossis sib npaug li 4.4% |
3.8% |
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Residue ntawm lgnition |
Tsawg dua lossis sib npaug rau 0.2% |
0.03% |
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Cov hlau hnyav |
Tsawg dua lossis sib npaug li 20ppm |
Ua raws |
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Residue Solvents |
Ethanol: Tsawg dua lossis sib npaug li 5000ppm |
200 ppm |
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Ethyl acetate: Tsawg dua lossis sib npaug li 5000ppm |
ND |
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Dimethylformamide: Tsawg dua lossis sib npaug rau 880ppm |
ND |
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2-propanot Tsawg dua lossis sib npaug li 5000ppm |
ND |
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N-heptane: Tsawg dua lossis sib npaug li 5000ppm |
320ppm ua |
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Triethylamine: Tsawg dua lossis sib npaug rau 720ppm |
ND |
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Lwm yam tshuaj (los ntawm HPLC) |
impurity 1 |
Impurity b (RRT{0}}.07): Tsawg dua lossis sib npaug li 0.20% |
ND |
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Impurity i (RRT{0}}.10): Tsawg dua lossis sib npaug li 0.20% |
ND |
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Lwm yam impurity: Tsawg dua lossis sib npaug rau 0.1% |
0.06% |
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impurity 2 |
Lwm yam impurities: Tsawg dua lossis sib npaug rau 0.1% |
0.07% |
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Tag nrho cov impurities los ntawm Txheej Txheem 1 thiab Txheej Txheem 2:s0.7% |
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Assay (Rau lub hauv paus tsis muaj dej) |
Ntawm 98.0% thiab 102.0% |
99.7% |
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Xaus |
Tsim nyog rau USP42 |
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Dab tsi yog qhov sib koom ntawm lopinavir thiab ritonavir?
Ob leeg lopinavir thiab ritonavir yog kab mob rov qab transcriptional inhibitors thiab protease inhibitor anti AIDS khoom. Lawv txwv tsis pub kis kab mob los ntawm kev thaiv kev faib ntawm Gag Pol poly protein los tsim cov kab mob tsis paub tab thiab tsis kis kab mob.
Peb paub tias P-gp thiab MRP2, uas tau nthuav tawm heev nyob rau ntawm qhov chaw luminal ntawm plab hnyuv epithelial hlwb, kho cov efflux twj tso kua mis, thiab cov metabolic uas nws kim heev ntawm CYP3A4 enzyme nyob rau hauv daim siab,
Txawm li cas los xij, tsis muaj dej solubility ntawm lopinavir nws tus kheej (40mg / mL) thiab tsis zoo bioavailability thaum noj qhov ncauj ua rau nws nyuaj rau kev siv tag nrho cov haujlwm ntawm cov khoom no.
Yog tias lub tswv yim los txhim kho bioavailability ntawm lopinavir tsom mus rau inhibiting lub cev muaj nuj nqi ntawm cov twj tso kua mis efflux, nws yuav muaj kev phiv loj rau lub cev.
Txawm hais tias ritonavir yog ib qho protease inhibitor thiab muaj zog inhibitory nyhuv ntawm CYP450 enzyme (CYP3A4 yog nws cov isoenzyme), cov kev mob tshwm sim ntawm cov khoom no yog pom tseeb heev thiab tsis tuaj yeem siv tag nrho ib zaug.
Cov ntaub ntawv soj ntsuam kuaj pom tau hais tias kev sib txuas ntawm ob, nrog lopinavir ua cov tshuaj tseem ceeb, thiab kev sib tw sib tw ntawm CYP3A4 nrog cov tshuaj tsawg ritonavir thiab lopinavir.
Nyob rau hauv txoj kev no, tsis tsuas yog kev sib xyaw ntawm lopinavir thiab viral protease tuaj yeem siv los tsim cov kab mob tsis paub tab thiab tsis kis kab mob; Nws tseem tuaj yeem ua rau cov nyhuv inhibitory ntawm ritonavir ntawm cov metabolism ntawm lopinavir hauv daim siab, yog li ua kom cov ntshav concentration ntawm lopinavir, txhim kho tag nrho cov txiaj ntsig ntawm cov khoom, thiab txo qis cov kev mob tshwm sim ntawm ob qho khoom.
Abbott Laboratories tau tsim ib qho kev sib xyaw ntawm lopinavir thiab ritonavir, suav nrog ib koob tshuaj lopinavir thiab ib lub hlis twg ntawm ritonavir. Qhov kev npaj no tau pom zoo los ntawm FDA rau kev lag luam hauv Tebchaws Meskas hauv xyoo 2000, thiab hauv Suav teb xyoo 2007.
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| 192725-17-0 Lopinavir | 155213-67-5 Ritonavir |
Peb lub tuam txhab tuaj yeem muab cov nqi qis Lopinavir thiab Ritonavir. Yog tias koj muaj kev npaj yuav khoom, thov hu rau peb ntawmemail:sales6@faithfulbio.com
Cov tshuaj twg yuav tsum tsis txhob noj ib txhij nrog Lopinavir thiab Ritonavir ntsiav tshuaj?
Lopinavir thiab ritonavir ntsiav tshuaj yog tsim nyog rau kev sib xyaw ua ke nrog lwm cov tshuaj tua kab mob los kho tus kab mob HIV, tab sis Lopinavir thiab ritonavir tsis tuaj yeem siv ib txhij nrog cov khoom hauv qab no:
1. Cov khoom uas cia siab rau CYP3A rau kev tshem tawm, xws li carbamazepine, 5, 5-Diphenylhydantoin, rifampicin, thiab nevirapine, induce lub metabolism ntawm lopinavir thiab txo nws cov ntshav cov tshuaj concentration.
2.Kev sib xyaw ua ke ntawm ritonavir thiab Dideoxyinosine tuaj yeem ua rau ob qho tib si tsis ua haujlwm. Yog li, ob cov tshuaj yuav tsum tau noj sib cais nrog qhov tsawg kawg nkaus ntawm 2.5 teev.
3. Efavirenz tuaj yeem txhawb cov metabolism ntawm lopinavir thiab ritonavir ntsiav tshuaj thiab txo cov ntshav tshuaj concentration ntawm cov khoom no. Thaum siv ua ke, qhov ntau npaum ntawm cov khoom no yuav tsum tau nce ntxiv.
4. Kev sib xyaw ua ke ntawm allicin lossis St. John's wort tuaj yeem txo cov ntshav concentration ntawm cov khoom no. Thaum siv ua ke, qhov ntau npaum ntawm cov khoom no yuav tsum tau nce ntxiv.
5.Lopinavir tuaj yeem txo cov ntshav siab ntawm Atovaquone, thiab thaum siv ua ke, nws yuav tsim nyog los nce koob tshuaj Atovaquone.
6.Nws tsis pom zoo kom siv cov tshuaj statins (xws li atorvastatin thiab rosuvastatin calcium) ua ke, tab sis yog tias tsim nyog ua ke, cov tshuaj yuav tsum tau hloov kho thiab kev saib xyuas kev nyab xeeb yuav tsum tau ua.
7.Kev ceev faj yuav tsum tau siv thaum siv cov khoom uas tuaj yeem ua rau QT ncua ntev, xws li quinidine, erythromycin, thiab clarithromycin. Vim hais tias cov khoom no yuav ua rau kom ntshav cov tshuaj concentration ntawm cov tshuaj siv tshuaj thiab ua rau muaj kev nce ntxiv hauv cov khoom cuam tshuam txog kev mob plawv.
8.Kev ceev faj yuav tsum tau siv thaum siv cov tshuaj uas tuaj yeem ua rau PR ncua sij hawm ntev, xws li verapamil lossis atazanavir, raws li qib 2 lossis 3rd degree atrioventricular block yuav tshwm sim.
Yog tias koj yuav tsum siv lwm cov tshuaj (xws li cov tshuaj noj lossis tshuaj tom khw, cov khoom ntuj, cov vitamins) thaum siv cov khoom no, koj yuav tsum xub tau txais kev tso cai los ntawm kws kho mob.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Peb lub zog:
Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev pom zoo nrog ntau lub chaw tsim khoom thiab chaw soj nstuam hauv Suav teb, Peb lub tuam txhab tuaj yeem muab cov khoom lag luam hais hauv tsab xov xwm no ntawm tus nqi zoo dua, xws liLopinavir hmoovCarbamazepine, Dideoxyinosine, Efavirenz, Allicin, Atovaquone, Atorvastatin, Clarithromycin, Verapamil thiab lwm yam. Yog tias koj txaus siab, thov sau ib tsab ntawv.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.
Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.
Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.
Cim npe nrov: lopinavir hmoov cas 192725-17-0, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Tuam Tshoj