Ursodeoxycholic acid yog dab tsi?
Ursodeoxycholic acid hmoovyog hmoov dawb; tsw tsw, iab. MP: 203-204 degree . Nws yog yooj yim soluble nyob rau hauv ethanol thiab glacial acetic acid, soluble nyob rau hauv sodium hydroxide test tov, thiab insoluble nyob rau hauv chloroform thiab chloroform. UDCA yog ib qho isomer ntawm CDCA, thiab nws cov nyhuv litholytic muaj zog dua CDCA, tsis muaj raws plab thiab lub siab toxicity. UDCA tuaj yeem txo qhov nqus ntawm cov roj cholesterol, thiab tuaj yeem txo cov synthesis ntawm cov roj (cholesterol) thiab cov roj (cholesterol) hauv cov kua tsib. Tsis tas li ntawd, UDCA tseem tuaj yeem txo cov concanavalin A binding fragment, uas tuaj yeem txhawb kev tsim cov kua tsib crystals, yog li inhibiting kev tsim cov pob zeb. Kev siv ua ke ntawm UDCA thiab CDCA tuaj yeem txhim kho cov nyhuv litholytic ntawm txhua tus ib leeg, thaum txo cov kev mob tshwm sim. Kev sib xyaw ua ke ntawm ob feem ntau yog siv los kho cov pob zeb hauv lub zais zis. Thaum tus neeg mob lub gallstones muaj qhov sib npaug ntawm cov kua tsib los yog CT tus nqi ntawm lub gallstones tsawg dua 75 units, lub pob zeb dissolving ceev ntawm UDCA yog qhov ceev tshaj plaws. Tom qab siv cov khoom no, cov neeg mob uas muaj tus mob cholelithiasis tuaj yeem nce cov platelets hauv peripheral.
Ursodeoxycholic acid yog ib yam khoom tshwj xeeb hauv dais bile. Lub neej ib nrab ntawm lub neej yog 3.5 txog 3.8 hnub. UDCA sai sai ua ke nrog glycine lossis taurine hauv daim siab, thiab tawm ntawm cov kua tsib mus rau hauv cov hnyuv me kom koom nrog cov kab mob enterohepatic. Ib feem ntawm UDCA khi rau hauv cov hnyuv me yog hydrolyzed rov qab rau hauv daim ntawv dawb; lwm qhov yog hloov dua siab tshiab rau hauv LCA raws li kev ua ntawm cov kab mob, thiab tom kawg yog sulfated, yog li txo nws cov peev xwm ua rau lub siab toxicity. Nws muaj cov teebmeem ntawm kev ua kom lub plab zom mov, inhibiting cholesterol deposition hauv cov ntshav, calming lub siab, txhawb cov kua tsib secretion, thiab detoxifying. Nws cov ntsev ntsev muaj zog dua li lwm cov kua qaub hauv kev txhawb nqa lub siab glycogen cia, fatty acid hydrolysis, thiab txo cov ntshav qab zib.
| Khoom npe | Ursodeoxycholic acid |
| CAS | 128-13-2 |
| Cov mis mos molecular | C24H40O4 |
| Molecular hnyav | 392.57 |
| EINECS Number | 204-879-3 |
| Kev cia khoom | 2-8 degree |
| Melting point | 203-204 degree (lit.) |
| Solubility | Ethanol: 50 mg / mL, qhia meej. |
| Qhov tshwm sim | Dawb hmoov |
| Boiling point | 437.26 degree (kev kwv yees ntxhib) |
| Qhov ntom | 0.9985 ( kwv yees kwv yees) |
Dab tsi yog pharmacological mechanism ntawm Ursodeoxycholic acid?
Ursodeoxycholic acid yog 7 -hydroxy diastereomer ntawm chenodeoxycholic acid. Nws yog qhov sib txawv me ntsis hauv cov qauv uas ua rauursodeoxycholic acid hmoovhydrophilic. Ursodeoxycholic acid tuaj yeem txo qis kev ua haujlwm ntawm -hydroxy- -methylglutaryl coenzyme A (HMG-CoA) reductase, tus nqi txwv enzyme rau kev tsim cov roj cholesterol hauv daim siab, yog li inhibiting cholesterol synthesis; thiab nws tsim cov kua dej ruaj khov crystalline ncua kev kawm nrog cov roj cholesterol, ua rau cov roj cholesterol hauv cov kua tsib tsis txaus, yog li txhawb cov nag lossis daus thiab tawg ntawm cov cholesterol hauv cov pob zeb. Ursodeoxycholic acid kuj tuaj yeem cuam tshuam txoj hnyuv nqus ntawm cov cholesterol. Ursodeoxycholic acid kuj tuaj yeem tiv thaiv cov nyhuv cytotoxic ntawm endogenous hydrophobic bile acids thiab tiv thaiv daim siab cell membranes. Ursodeoxycholic acid exerts ib tug immunomodulatory nyhuv los ntawm kev txo lub overexpression ntawm loj histocompatibility antigen MHC-1 ntawm daim siab cell membrane; inhibiting zus tau tej cov interleukins -2, 4, qog necrosis yam thiab interferon; nce qib ntawm interleukins-10 thiab 12 hauv lub cev; thiab ncaj qha khi rau glucocorticoid receptors. Tsis tas li ntawd, ursodeoxycholic acid kuj muaj cov teebmeem ntawm inhibiting cell apoptosis, inhibiting o, tshem tawm dawb radicals thiab anti-oxidation.
Khoom Specification
| Yam khoom | Specification | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb hmoov | Ua raws |
| Kev txheeb xyuas | Ua tau raws li qhov yuav tsum tau ua | Ua raws |
| Hnyav Hlau | Tsawg dua lossis sib npaug li 10ppm | 5ppm ua |
| Hlau | Tsawg dua lossis sib npaug li 10ppm | 3ppm ua |
| Chloride | Tsawg dua los yog sib npaug rau 0.05% | 0.01% |
| Arsenic | Tsawg dua lossis sib npaug li 2ppm | 0.5ppm |
| Poob rau ziab | Tsawg dua lossis sib npaug rau 1.0% | 0.3% |
| Redidue ntawm Ignition | Tsawg dua lossis sib npaug rau 0.1% | 0.06% |
| Assay | Ntau dua lossis sib npaug rau 98.0% | 99.37% |
| Xaus: | Ua raws li kev lag luam specification. | |
Dab tsi yog qhov cuam tshuam ntawm ursodeoxycholic acid?
Ursodeoxycholic acid hmoovfeem ntau muaj cov teebmeem ntawm kev txhawb nqa cov kua tsib zais cia, tswj cov kua tsib kua tsib, txhim kho daim siab ua haujlwm, tiv thaiv lub siab hlwb, thiab txo cov kua tsib stasis.
1. Txhawb cov kua tsib
Ursodeoxycholic acid tuaj yeem ua rau kom cov kua tsib kua qaub, thiab tseem tuaj yeem cuam tshuam kev nqus cov roj cholesterol hauv cov kua tsib, yog li ua kom cov roj cholesterol tawm hauv cov kua tsib, ua lub luag haujlwm hauv kev txhawb cov kua tsib.
2. Tswj cov kua tsib kua tsib
Ursodeoxycholic acid tuaj yeem ua rau cov kua tsib acid ntau ntxiv hauv cov kua tsib, yog li txhim kho cov kua tsib thiab pab daws qhov tsis xis nyob los ntawm kev txo cov kua tsib.
3. Txhim kho daim siab ua haujlwm
Ursodeoxycholic acid tuaj yeem txhim kho daim siab ua haujlwm, feem ntau yog los ntawm kev txhawb nqa kev tsim tawm ntawm daim siab hlwb, yog li ua tiav cov txiaj ntsig ntawm kev txhim kho daim siab ua haujlwm.
4. Tiv thaiv daim siab hlwb
Ursodeoxycholic acid tuaj yeem tiv thaiv daim siab hlwb, feem ntau los ntawm inhibiting cov roj cholesterol hauv daim siab, yog li ua tiav cov txiaj ntsig ntawm kev tiv thaiv daim siab hlwb.
5. Txo cov kua tsib stasis
Ursodeoxycholic acid tuaj yeem txo cov kua tsib stasis, feem ntau los ntawm kev txhawb nqa cov kua tsib, yog li ua tiav cov txiaj ntsig ntawm kev txo cov kua tsib stasis.
HTML5 atlas ntawm Ursodeoxycholic acid
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IR1 ntawm Ursodeoxycholic acid
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Cov teebmeem tseem ceeb ntawm Ursodeoxycholic acid yog dab tsi?
1. Cytoprotective nyhuv. UDCA conjugates tuaj yeem txo cov cell lysis ntawm hepatocytes induced los ntawm hydrophobic bile acid thiab txo cov apoptosis ntawm kab lis kev cai nas thiab tib neeg hepatocytes induced los ntawm cov kua tsib kua qaub.
2. Membrane stabilizing nyhuv. UDCA tuaj yeem tiv thaiv cov kev hloov pauv hauv permeability ntawm mitochondrial daim nyias nyias vim los ntawm cov kua tsib kua qaub, uas yog, nws tuaj yeem tiv thaiv kev puas tsuaj ntawm mitochondrial daim nyias nyias, hauv qab daim nyias nyias thiab cov kua tsib me me ntawm cov kua tsib uas cuam tshuam los ntawm cov kua tsib kua qaub los ntawm daim nyias nyias stabilization.
3. Antioxidant nyhuv. UDCA tuaj yeem cuam tshuam qhov ua kom cov Kupffer hlwb tshwm sim los ntawm cov kua tsib kua qaub, thiab tseem tuaj yeem ua rau nce qib ntawm glutathione thiab thiol-muaj cov proteins hauv hepatocytes los tiv thaiv oxidative puas tsuaj rau hepatocytes.
4. Immunomodulatory nyhuv. UDCA indirects inhibits los ntawm kev txo cov stimulation ntawm hydrophobic bile acid, thiab ncaj qha inhibits kev qhia ntawm chav kawm I thiab chav kawm ntawv II noob ntawm histocompatibility complex (MHC) los ntawm activating glucocorticoid receptors.
Dab tsi yog qhov txawv ntawm ursodeoxycholic acid, hyodeoxycholic acid thiab chenodeoxycholic acid?
Chenodeoxycholic acid
Cov teebmeem ntawm chenodeoxycholic acid: Cov khoom no yog ib qho ntawm cov tshuaj siv ntau tshaj plaws rau kev kho mob gallstones hauv ntiaj teb, thiab nws tseem yog cov khoom siv raw rau kev sib txuas ntawm ursodeoxycholic acid (UDCA) thiab lwm cov tshuaj steroid.
Lub luag haujlwm tseem ceeb ntawm chenodeoxycholic acid (CDCA) yog txhawm rau txo qis cov roj cholesterol hauv cov kua tsib, thiab cov roj cholesterol nyob hauv lub xeev tsis txaus, kom cov roj cholesterol hauv cov pob zeb dissolves thiab poob tawm. Cov koob tshuaj loj ntawm CDCA tuaj yeem cuam tshuam cov synthesis ntawm cov roj cholesterol thiab ua kom cov kua tsib tso tawm hauv cov neeg mob cholelithiasis, tab sis cov kua tsib ntsev thiab phospholipids tseem tsis hloov.
Hyodeoxycholic acid
Cov teebmeem ntawm hyodeoxycholic acid: Cov khoom no yog cov kua tsib kua qaub rho tawm los ntawm cov kua tsib. Nws tuaj yeem cuam tshuam kev tsim cov kua tsib kua qaub thiab yaj cov rog, txo cov roj cholesterol thiab triglycerides, thiab tsim nyog rau hom ⅰa lossis ⅰb hyperlipidemia thiab atherosclerosis. Nws muaj qee yam tshuaj tua kab mob ntawm Bordetella pertussis, Bordetella diphtheria, Staphylococcus aureus, thiab lwm yam. Nws tuaj yeem siv los ua cov tshuaj tiv thaiv kab mob los kho tus mob bronchitis, kab mob ua pa sab sauv hauv cov menyuam yaus, thiab lwm yam. Cov khoom no tuaj yeem tsim cov kua tsib, ua kom cov kua tsib thinner yam tsis tau nce cov khoom khib nyiab; Nws kuj tseem tuaj yeem ua kom lub cev tawm ntawm cholecystography sib piv tus neeg sawv cev los ntawm lub siab thiab pab nrog cov duab. Nws tseem tuaj yeem txhawb txoj hnyuv plab zom mov thiab muaj roj-soluble vitamin nqus, thiab tuaj yeem siv rau kev zom zaub mov los ntawm kab mob hepatobiliary.
Ursodeoxycholic acid
Ursodeoxycholic acid cuam tshuam: cholesterol gallstones. Primary cholestatic cirrhosis, thawj sclerosing cholangitis. Cov kua tsib reflux gastritis. Cov khoom no yog siv rau kev tsim cov cholesterol gallstone thiab cov kua tsib tsis txaus steatorrhea, thiab tseem tuaj yeem siv los tiv thaiv kev tsim cov pob zeb los ntawm cov tshuaj thiab kho steatorrhea.
Dab tsi yog kev ceev faj rau kev siv Ursodeoxycholic Acid hmoov?
1. Kev siv lub sij hawm ntev ntawm Ursodeoxycholic Acid Powder tuaj yeem ua rau cov platelet peripheral ntau ntxiv.
2. Yog hais tias muaj rov tshwm sim ntawm biliary colic nyob rau hauv kev kho mob ntawm cov cholesterol pob zeb, cov tsos mob tsis zoo los yog txawm aggravated, los yog pom tseeb calcification ntawm pob zeb tshwm sim, kev kho mob yuav tsum tau nres.
3. Ursodeoxycholic Acid tsis tuaj yeem yaj cov kua tsib xim pob zeb, cov pob zeb sib xyaw thiab X-ray opaque pob zeb.
Yuav ua li cas thiab qhov twg yuav Ursodeoxycholic Acid Powder lag luam wholesale?
Koj tuaj yeem tso siab rau peb qhov kev txiav txim vim tias peb muaj cov ntaub ntawv zoo ntawm kev muag tshuaj raws cai.
Peb ua qhov kev kuaj xyuas ywj pheej ntawm txhua yam khoom thiab tom qab ntawd muag rau peb cov neeg siv khoom hwm.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Tsis lees paub: Cov ntawv luam tawm ntawm lub xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.
Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho, lossis tiv thaiv txhua yam kab mob.
Cim npe nrov: ursodeoxycholic acid hmoov cas 128-13-2, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua hauv Suav teb