azidothymidineyog ib qho tshuaj siv los ncua kev txhim kho ntawm AIDS (tau txais cov kab mob tiv thaiv kab mob) hauv cov neeg mob HIV (tus kab mob tiv thaiv kab mob tib neeg).AZTbelongs rau ib pawg ntawm cov tshuaj hu ua nucleoside reverse transcriptase inhibitors (NRTIs). Xyoo 1987 AZT tau los ua thawj cov tshuaj no tau pom zoo los ntawm US Food and Drug Administration rau lub hom phiaj ntawm kev ua neej ntev ntawm cov neeg mob AIDS.
Txog cov tshuaj pharmacological ntawm cov khoom no
zidovudineyog ib qho tshuaj tiv thaiv kab mob uas muaj kev ua haujlwm siab tiv thaiv retroviruses nrog rau tib neeg kev tiv thaiv kab mob (HIV) hauv vitro. Nws yog phosphorylated rau hauv zidovudine triphosphate los ntawm thymidine kinase hauv cov kab mob kis kab mob, uas tuaj yeem xaiv inhibit HIV thim rov qab enzyme, ua rau kev txiav tawm ntawm HIV chain synthesis, yog li tiv thaiv HIV replication.
Yuav ua li cas rau overuse ntawm cov khoom no?
Cov xwm txheej cuam tshuam nrog cov neeg laus thiab cov menyuam yaus uas muaj koob tshuaj ntau dua 50g tau tshaj tawm, thiab tsis muaj leej twg tuag. Cov xwm txheej tshaj tawm no yog tshwm sim los yog ua rau xeev siab thiab ntuav. Cov ntshav hloov pauv tsis tu ncua thiab tsis loj, thiab qee cov neeg mob muaj cov tsos mob ntawm lub paj hlwb uas tsis muaj qhov tshwj xeeb, xws li mob taub hau, kiv taub hau, tsaug zog, qaug zog, thiab tsis nco qab. Ib tug txiv neej muaj hnub nyoog 35- xyoo tau noj 36g ntawm cov khoom no ib zaug, thiab nws tau qaug dab peg 3 teev tom qab. Vim tsis muaj lwm yam tshwm sim, nws yuav tshwm sim los ntawm kev siv tshuaj. Txhua tus neeg mob rov zoo tsis muaj sequelae. Hemodialysis lossis peritoneal dialysis tsis muaj kev cuam tshuam rau kev tshem tawm ntawm cov khoom no, tab sis lub excretion ntawm nws cov metabolite GZDV nce.
Hais txog pharmacokinetics ntawm cov khoom no
zidovudineua ke nrog DNA polymerase ntawm tus kab mob kom nres qhov kev loj hlob ntawm DNA saw, yog li inhibiting tus kab mob replication. Tib neeg - DNA polymerase muaj kev cuam tshuam me ntsis rau tib neeg cov cell proliferation.
Tom qab siv lub capsule, nws yog absorbed sai heev. Tom qab thawj zaug dhau metabolism, bioavailability yog 52 feem pua - 75 feem pua. Tom qab tso dej ntawm 2.5mg / kg rau 1 teev lossis kev tswj qhov ncauj ntawm 5mg / kg, cov tshuaj ntshav siab tuaj yeem ncav cuag 4 ~ 6 μ mol / L (1.1-1.6mg / L); 4 teev tom qab kev tswj hwm, cerebrospinal kua concentration tuaj yeem ncav cuag 50 ~ 60 feem pua ntawm cov ntshav plasma; VD=1.6L/kg; Cov protein khi tus nqi yog li 34 ~ 38 feem pua; Cov khoom lag luam feem ntau yog glucuronide rau hauv qhov tsis muaj zog saib hauv daim siab; Ib teev tom qab siv. Kwv yees li 14 feem pua ntawm cov tshuaj tau tawm mus rau hauv cov zis los ntawm glomerular pom thiab nquag nkag mus rau lub raum tubules; 74 feem pua ntawm cov metabolites kuj raug tso tawm los ntawm cov zis. Rau kev kho mob ntawm kis kab mob immunodeficiency syndrome (AIDS). Thaum cov neeg mob muaj teeb meem (Pneumocystis carinii los yog lwm yam kab mob), lawv yuav tsum tau kho nrog rau lwm cov tsos mob.
Lub tuam txhab tuaj yeem muab cov khoom muaj feem xyuam. Yog tias koj txaus siab, thov hu rau peb raws sijhawm
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