Hauv Tebchaws Meskas thiab European Union,Ruxolitinib hmoovyog qhia rau kev kho mob ntawm tus kab mob ntsig txog splenomegaly lossis cov tsos mob hauv cov neeg laus uas muaj thawj myelofibrosis (tseem hu ua chronic idiopathic myelofibrosis), post-polycythemia-vera myelofibrosis, lossis post-tseem ceeb thrombocythemia myelofibrosis. Nws kuj tau qhia rau kev kho cov neeg laus nrog polycythemia vera uas tiv taus lossis tsis kam ntawm hydroxyurea.941678-49-5 Ruxolitinibkuj tau qhia rau kev kho mob ntawm steroid-refractory mob graft-tiv thaiv-tus kab mob nyob rau hauv cov neeg uas muaj hnub nyoog kaum ob xyoos thiab laus dua, thiab rau kev kho mob ntawm chronic graft-tiv thaiv-tus kab mob (cGVHD) tom qab tsis ua hauj lwm ntawm ib los yog ob tug. kab ntawm kev kho mob hauv cov neeg muaj hnub nyoog kaum ob xyoos thiab laus dua.
Ruxolitinib creamyog qhia rau kev kho mob ntawm me me mus rau nruab nrab atopic dermatitis (AD). Muag subOpzelurabrand nyob rau hauv lub tebchaws United States
JAK inhibitors yog dab tsi thiab lawv ua haujlwm li cas?
Hauv cov tshuaj, vitiligo yog ib qho kab mob autoimmune, uas yuav ua rau lub cev tsis muaj zog tiv thaiv kab mob los tua melanocytes (melanocytes yog cov cell uas muab cov tawv nqaij xim), uas yuav ua rau cov tawv nqaij bleaching thiab whitening. JAKs belongs rau tsev neeg ntawm cytoplasmic tyrosine kinases, uas nws txoj haujlwm yog los hloov cov teeb liab los ntawm cytokines (xws li interferon). Los ntawm kev tshawb fawb, peb pom tias txoj kev kho mob ntawm JAK inhibitor yog tias JAK protein yog lub luag haujlwm xa cov cim rau lub cev tiv thaiv kab mob los tua melanocytes thaum lub sij hawm tsim vitiligo. JAK inhibitors tiv thaiv JAK protein los ntawm kev ua li ntawd hauv cov txheej txheem no, uas tiv thaiv qhov muag tsis pom kev ntawm lub cev tiv thaiv kab mob, yog li tiv thaiv kev tsim ntawm vitiligo.
Yog vim li cas vim li cas txoj kev tshawb no yog qhov tseeb yog tias piv nrog cov kev kho mob tam sim no, qhov kev kho JAK no yog lub hom phiaj ntau dua thiab muaj kev nyab xeeb dua. Nws yog hom phiaj kho mob, uas txhais tau hais tias JAK inhibitors tsom rau kev tiv thaiv ib feem ntawm lub cev tiv thaiv kab mob, tsis yog tawm tsam lub cev tiv thaiv kab mob, thiab ua rau muaj kev cuam tshuam tsis zoo. Qhov no yog ib qho tseem ceeb heev, yog li thaum nws suppresses lub cev tsis muaj zog, koj lub cev muaj zog tseem tuaj yeem tiv taus lwm yam kab mob, thiab nws txoj kev tiv thaiv yog qhov tsis muaj kev cuam tshuam.
Dab tsi yog JAK inhibitors peb tuaj yeem siv?
Tam sim no, muaj ob hom tshuaj pom zoo los ntawm FDA rau kev kho mob ntawm cov kab mob inflammatory-tofacitinib thiab ruxolitinib.
Txawm li cas los xij, ntawm cov kev kho mob no, kev kho mob vitiligo tsis suav nrog tam sim no (nws tsis tau pom zoo los ntawm FDA), tab sis koj tuaj yeem tsim thawj vitiligo. Kev siv cov khoom no tuaj yeem ncua kev sib kis ntawm vitiligo.
Hauv qab no yog cov lus piav qhia ntxaws ntawm ob yam khoom
Tofacitinib
Tofacitinib yog FDA-pom zoo tshuaj qhov ncauj rau kev kho mob rheumatoid mob caj dab thiab psoriatic mob caj dab. Yog vim li cas siv Xeljanz hauv vitiligo yog tias nws tsom rau ob JAK proteins (JAK 1 thiab TYK 2), suav nrog cov neeg tshwj xeeb rau vitiligo.
Daim ntawv tshaj tawm tshawb fawb xyoo 2015 tau pom tias txhais tes thiab lub ntsej muag ntawm tus neeg mob vitiligo tau ua tiav zoo dua tom qab kho nrog tofacitinib. Lwm cov kev tshawb fawb tau pom tias kev kho mob ntawm vitiligo nrog tofacitinib yuav xav tau lub teeb. Qhov no txawv ntawm qhov tam sim no phototherapy rau vitiligo. Txawm tias thaum lub teeb hluav taws xob qis (lub teeb nrog lub zog qis heev) ua ke nrog JAK inhibitor, nws txaus kom loj hlob pigment.
Ruxolitinib
Ruxolitinib phosphate hmoovyog lwm FDA-pom zoo JAK inhibitor.Ruxolitinib phosphateLub hom phiaj ob lub proteins suav nrog JAK 1, tom kawg uas tau koom nrog hauv kev txhim kho vitiligo.
Hauv xyoo 2016, tus kws kho mob dermatologist tau luam tawm ib tsab xov xwm hais txog yuav ua li cas qhov ncaujRuxolitinib phosphate 1092939-17-7tuaj yeem txhim kho vitiligo sai sai, taw qhia tias daim ntawv tshaj tawm ntawm kev sib koom ua ke ntawm lub ntsej muag melanosis hauv cov neeg mob vitiligo thiab cov neeg mob alopecia areata, uas yog, alopecia areata thiab vitiligo yog tshwm sim los ntawm autoimmunity, ua rau cov neeg mob uas muaj qhov txhab los ntawm ntau qhov chaw. Cov kev tshawb fawb cuam tshuam yog: tias 12 tus neeg mob vitiligo tau kho nrog 1.5 feem pua ruxolitinib cream, thiab cov txiaj ntsig tau txawv heev. Nyob rau tib lub sijhawm, nyob rau hauv qhov kev sim thib ob, nws tau pom tias cov neeg mob alopecia areata tau ua kom zoo dua qub los ntawm kev kho mob vitiligo.
Kev txhim kho yav tom ntej ntawm JAK inhibitors hauv kev kho mob vitiligo
Qeb los ntawm cov kev taw qhia ntawm kev tshawb fawb kev kho mob, JAK kinase signaling pathway thiab lwm yam cytokines yog cov kub kub hauv kev kho mob ntawm vitiligo, ua raws li kev kho mob antioxidant thiab recolorization. Nws tsim nyog ntseeg tias cov tshuaj tiv thaiv kab mob hauv zos tuaj yeem yog lwm txoj hauv kev rau steroids hauv zos vitiligo. Cov xim tshiab tshiab, xws li qhov yooj yim fibroblast loj hlob zoo, suav nrog Alfa peptide, yuav maj mam hloov. JAK inhibitor tam sim no yog cov tshuaj tshiab tshaj plaws rau kev kho mob vitiligo, thiab cov nyhuv ntawm kev siv ua ke nrog Nb UVB (311) zoo dua. Txawm li cas los xij, peb tseem yuav tsum tau tos kom tau txais kev tshawb fawb ntxiv los ntsuas qhov ua tau zoo, kev nyab xeeb, thiab lub sijhawm ntev ntawm JAK.
Lub tuam txhab tuaj yeem muab cov khoom muaj feem xyuam. Yog tias koj txaus siab, thov hu rau peb raws sijhawm
Tus kws muag khoom tshwj xeeb: (Allen)
Email:allen@faithfulbio.com
WhatsApp/Skype/Telegram: ntxiv rau 86 13137770562
Sales specialist: (Tina)
Email:sales2@faithfulbio.com
WhatsApp/Skype/Telegram: ntxiv rau 86 177 8986 8285
Kev muag khoom tshwj xeeb: (sunny)
Email:sunny@faithfulbio.com
WhatsApp/Skype/Telegram: ntxiv rau 86 13262001053