Fludarabine hmoov CAS 21679-14-1

Fludarabine Hmoovyog cov tshuaj antitor. Fludarabine yog anti-metabolic purine nucleoside fluoride analogue, uas yog xaiv heev rau lymphocytes. Nws tuaj yeem tsim DNA kho hauv cov cav ntoo thiab DNA synthesis hauv kev faib cov hlwb, thiab txhawb nqa lub hlwb ntawm cov hlwb no. Fludarabine tau qhia zoo kho cov nyhuv zoo, thiab tau siv dav hauv kev kho cov ntshav ntawm cov ntshav. Tshwj xeeb tshaj yog B Lymphocytic leukemia.

Cov tshuaj yog fluorinated analogue of Adenosine Arabine, uas yog tus tawm tsam tiv thaiv ntawm adenosine deaminase. Fludarabine phosphate yog sai sai dephosphorationlated rau 2f-ara-a, uas tuaj yeem nqa los ntawm instagellular deoxycytidine Kinase mus rau cov nquag mus rau Trackhosphate 2F-ARA-ATP. Cov metabolite tuaj yeem cuam tshuam DNA synthesis los ntawm inhibiting nucleotide rolluctase, DNA primer enzyme, thiab DNA ligase. Ib qho ntxiv, RNA Polymerase II tuaj yeem yog qee cov neeg inhibited los txo cov protein synthesis.